NMR of biomolecules : towards mechanistic systems biology / [electronic resource]
Nuclear magnetic resonance of biomolecules
edited by Ivano Bertini, Kathleen S. McGreevy, Giacomo Parigi.
- 1 online resource (1 onine resource (xxxviii, 612 pages)) : illustrations
Includes bibliographical references and index.
Introduction. NMR and its Place in Mechanistic Systems Biology / Structure of Biomolecules: Fundamentals / What Can be Learned about the Structure and Dynamics of Biomolecules from NMR / Role of NMR in the Study of the Structure and Dynamics of Biomolecules. Determination of Protein Structure and Dynamics / DNA / RNA / Intrinsically Disordered Proteins / Paramagnetic Molecules / Role of NMR in the Study of the Structure and Dynamics of Biomolecular Interactions. NMR Methodologies for the Analysis of Protein₆Protein Interactions / Protein₆Paramagnetic Protein Interactions / Protein₆RNA Interactions / Protein₆DNA Interactions / NMR in Drug Discovery. High-Throughput Screening and Fragment-Based Design: General Considerations for Lead Discovery and Optimization / Ligand-Observed NMR in Fragment-Based Approaches / Interactions of Metallodrugs with DNA / RNA as a Drug Target / Fluorine NMR Spectroscopy for Biochemical Screening in Drug Discovery / NMR of Peptides / Solid-State NMR. Biomolecular Solid-State NMR/Basics / Protein Dynamics in the Solid State / Microcrystalline Proteins ₆ An Ideal Benchmark for Methodology Development / Structural Studies of Protein Fibrils by Solid-State NMR / Solid-State NMR on Membrane Proteins: Methods and Applications / Frontiers in NMR Spectroscopy. Dynamic Nuclear Polarization / C Direct Detection NMR / Speeding up Multidimensional NMR Data Acquisition / Metabolomics / In-Cell Protein NMR Spectroscopy / Structural Investigation of Cell-Free Expressed Membrane Proteins / Computational Aspects. Grid Computing / Protein₆Protein Docking with HADDOCK / Automated Protein Structure Determination Methods / NMR Structure Determination of Protein₆Ligand Complexes / Small Angle X-Ray Scattering/Small Angle Neutron Scattering as Methods Complementary to NMR / Ivano Bertini, Kathleen S McGreevy, Giacomo Parigi -- Lucia Banci, Francesca Cantini, Mirko Cevec, Hendrik R A Jonker, Senada Nozinovic, Christian Richter, Harald Schwalbe -- Lucio Ferella, Antonio Rosato, Paola Turano, Janez Plavec -- Lucio Ferella, Antonio Rosato, Paola Turano -- Janez Plavec -- Richard ⁽tefl, Vladim̕r Skleǹr -- Isabella C Felli, Roberta Pierattelli, Peter Tompa -- Ivano Bertini, Claudio Luchinat, Giacomo Parigi -- Tobias Madl, Michael Sattler -- Metal-Mediated Interactions / Simone Ciofi-Baffoni -- Peter H J Keizers, Yoshitaka Hiruma, Marcellus Ubbink -- Vijayalaxmi Manoharan, Jose Manuel P̌rez-Cąadillas, Andres Ramos -- Lidija Kovacic, Rolf Boelens -- Maurizio Pellecchia -- Pawel Sledz, Chris Abell, Alessio Ciulli -- Hong-Ke Liu, Peter J Sadler -- Jan-Peter Ferner, Elke Duchardt Ferner, J̲rg Rinnenthal, Janina Buck, Jens W̲hnert, Harald Schwalbe -- Claudio Dalvit -- Johannes G Beck, Andreas O Frank, Horst Kessler -- Emeline Barbet-Massin, Guido Pintacuda -- J̤zef R Lewandowski, Lyndon Emsley -- W Trent Franks, Barth-Jan van Rossum, Benjamin Bardiaux, Enrico Ravera, Giacomo Parigi, Claudio Luchinat, Hartmut Oschkinat -- Anja B̲ckmann, Beat H Meier -- A A Cukkemane, M Renault, M Baldus -- Thomas F Prisner -- Isabella C Felli, Roberta Pierattelli -- Bernhard Brutscher, Dominique Marion, Lucio Frydman -- Leonardo Tenori -- David S Burz, David Cowburn, Kaushik Dutta, Alexander Shekhtman -- Solmaz Sobhanifar, Sina Reckel, Frank L̲hr, Frank Bernhard, Volker D̲tsch -- Antonio Rosato -- Christophe Schmitz, Adrien S J Melquiond, Sjoerd J de Vries, Ezgi Karaca, Marc van Dijk, Panagiotis L Kastritis, Alexandre M J J Bonvin -- Paul Guerry, Torsten Herrmann -- Ulrich Schieborr, Sridhar Sreeramulu, Harald Schwalbe -- M V Petoukhov, D I Svergun.
9783527644506 3527644504 9783527644520 3527644520 3527644512 9783527644513 3527644539 9783527644537 9781283644037 1283644037
9786613956538
10.1002/9783527644506 Wiley InterScience http://www3.interscience.wiley.com
Biomolecules.
Biological systems.
Nuclear magnetic resonance spectroscopy.
Systems biology.
Nuclear Magnetic Resonance, Biomolecular.
Proteins--chemistry.
Nucleic Acids--chemistry.
Systems Biology.
SCIENCE--Life Sciences--Biochemistry.
Biological systems.
Biomolecules.
Nuclear magnetic resonance spectroscopy.
Systems biology.
Biomolekül
NMR-Spektroskopie
Electronic books.
QP519.9.N83 / N67 2012
572
2012 F-296 QU 25 190
Includes bibliographical references and index.
Introduction. NMR and its Place in Mechanistic Systems Biology / Structure of Biomolecules: Fundamentals / What Can be Learned about the Structure and Dynamics of Biomolecules from NMR / Role of NMR in the Study of the Structure and Dynamics of Biomolecules. Determination of Protein Structure and Dynamics / DNA / RNA / Intrinsically Disordered Proteins / Paramagnetic Molecules / Role of NMR in the Study of the Structure and Dynamics of Biomolecular Interactions. NMR Methodologies for the Analysis of Protein₆Protein Interactions / Protein₆Paramagnetic Protein Interactions / Protein₆RNA Interactions / Protein₆DNA Interactions / NMR in Drug Discovery. High-Throughput Screening and Fragment-Based Design: General Considerations for Lead Discovery and Optimization / Ligand-Observed NMR in Fragment-Based Approaches / Interactions of Metallodrugs with DNA / RNA as a Drug Target / Fluorine NMR Spectroscopy for Biochemical Screening in Drug Discovery / NMR of Peptides / Solid-State NMR. Biomolecular Solid-State NMR/Basics / Protein Dynamics in the Solid State / Microcrystalline Proteins ₆ An Ideal Benchmark for Methodology Development / Structural Studies of Protein Fibrils by Solid-State NMR / Solid-State NMR on Membrane Proteins: Methods and Applications / Frontiers in NMR Spectroscopy. Dynamic Nuclear Polarization / C Direct Detection NMR / Speeding up Multidimensional NMR Data Acquisition / Metabolomics / In-Cell Protein NMR Spectroscopy / Structural Investigation of Cell-Free Expressed Membrane Proteins / Computational Aspects. Grid Computing / Protein₆Protein Docking with HADDOCK / Automated Protein Structure Determination Methods / NMR Structure Determination of Protein₆Ligand Complexes / Small Angle X-Ray Scattering/Small Angle Neutron Scattering as Methods Complementary to NMR / Ivano Bertini, Kathleen S McGreevy, Giacomo Parigi -- Lucia Banci, Francesca Cantini, Mirko Cevec, Hendrik R A Jonker, Senada Nozinovic, Christian Richter, Harald Schwalbe -- Lucio Ferella, Antonio Rosato, Paola Turano, Janez Plavec -- Lucio Ferella, Antonio Rosato, Paola Turano -- Janez Plavec -- Richard ⁽tefl, Vladim̕r Skleǹr -- Isabella C Felli, Roberta Pierattelli, Peter Tompa -- Ivano Bertini, Claudio Luchinat, Giacomo Parigi -- Tobias Madl, Michael Sattler -- Metal-Mediated Interactions / Simone Ciofi-Baffoni -- Peter H J Keizers, Yoshitaka Hiruma, Marcellus Ubbink -- Vijayalaxmi Manoharan, Jose Manuel P̌rez-Cąadillas, Andres Ramos -- Lidija Kovacic, Rolf Boelens -- Maurizio Pellecchia -- Pawel Sledz, Chris Abell, Alessio Ciulli -- Hong-Ke Liu, Peter J Sadler -- Jan-Peter Ferner, Elke Duchardt Ferner, J̲rg Rinnenthal, Janina Buck, Jens W̲hnert, Harald Schwalbe -- Claudio Dalvit -- Johannes G Beck, Andreas O Frank, Horst Kessler -- Emeline Barbet-Massin, Guido Pintacuda -- J̤zef R Lewandowski, Lyndon Emsley -- W Trent Franks, Barth-Jan van Rossum, Benjamin Bardiaux, Enrico Ravera, Giacomo Parigi, Claudio Luchinat, Hartmut Oschkinat -- Anja B̲ckmann, Beat H Meier -- A A Cukkemane, M Renault, M Baldus -- Thomas F Prisner -- Isabella C Felli, Roberta Pierattelli -- Bernhard Brutscher, Dominique Marion, Lucio Frydman -- Leonardo Tenori -- David S Burz, David Cowburn, Kaushik Dutta, Alexander Shekhtman -- Solmaz Sobhanifar, Sina Reckel, Frank L̲hr, Frank Bernhard, Volker D̲tsch -- Antonio Rosato -- Christophe Schmitz, Adrien S J Melquiond, Sjoerd J de Vries, Ezgi Karaca, Marc van Dijk, Panagiotis L Kastritis, Alexandre M J J Bonvin -- Paul Guerry, Torsten Herrmann -- Ulrich Schieborr, Sridhar Sreeramulu, Harald Schwalbe -- M V Petoukhov, D I Svergun.
9783527644506 3527644504 9783527644520 3527644520 3527644512 9783527644513 3527644539 9783527644537 9781283644037 1283644037
9786613956538
10.1002/9783527644506 Wiley InterScience http://www3.interscience.wiley.com
Biomolecules.
Biological systems.
Nuclear magnetic resonance spectroscopy.
Systems biology.
Nuclear Magnetic Resonance, Biomolecular.
Proteins--chemistry.
Nucleic Acids--chemistry.
Systems Biology.
SCIENCE--Life Sciences--Biochemistry.
Biological systems.
Biomolecules.
Nuclear magnetic resonance spectroscopy.
Systems biology.
Biomolekül
NMR-Spektroskopie
Electronic books.
QP519.9.N83 / N67 2012
572
2012 F-296 QU 25 190