Synthetic methods for biologically active molecules : exploring the potential of bioreductions / [electronic resource]
edited by Elisabetta Brenna.
- 1 online resource (xviii, 387 pages) : illustrations
Includes bibliographical references and index.
Development of Sustainable Biocatalytic Reduction Processes for Organic Chemists / Roland Wohlgemuth -- Reductases: From Natural Diversity to Established Biocatalysis and to Emerging Enzymatic Activities / Elena Fernández-Álvaro, Pablo Domínguez de María -- Synthetic Strategies Based on C=C Bioreductions for the Preparation of Biologically Active Molecules / Francesco G Gatti, Fabio Parmeggiani, Alessandro Sacchetti -- Synthetic Strategies Based on C=O Bioreductions for the Preparation of Biologically Active Molecules / Aníbal Cuetos, Alba Díaz-Rodríguez, Iván Lavandera -- Protein Engineering: Development of Novel Enzymes for the Improved Reduction of C=C Double Bonds / Sabrina Kille, Manfred T Reetz -- Protein Engineering: Development of Novel Enzymes for the Improved Reduction of C=O Double Bonds / Nobuya Itoh, Yoshihide Makino -- Synthetic Applications of Aminotransferases for the Preparation of Biologically Active Molecules / Sachin Pannuri, Sanjay Kamat, Abraham R Mártin-García -- Strategies for Cofactor Regeneration in Biocatalyzed Reductions / Selin Kara, Joerg H Schrittwieser, Frank Hollmann -- Solvent Effects in Bioreductions / Yan Ni, Hui-Lei Yu, Jian-He Xu -- Application of Product Removal (ISPR) Technologies for Implementation and Scale-Up of Biocatalytic Reductions / John M Woodley -- Bioreductions in Multienzymatic One-Pot and Cascade Processes / Daniela Monti, Erica E Ferrandi -- Dynamic Kinetic Resolutions Based on Reduction Processes / Dimitris Kalaitzakis, Ioulia Smonou -- Relevant Practical Applications of Bioreduction Processes in the Synthesis of Active Pharmaceutical Ingredients / Gábor Tasnádi, Mélanie Hall.
This ready reference focuses on the currently available toolbox of biocatalysed reductions of C=O, C=C and formal C=N double bonds to show which transformations are reliable for use in manufacturing processes and which still require improvements and investigation. Following an introductory chapter, chapters 2-4 present the synthetic strategies which are currently available for the reduction of C=C, C=O and for reductive amination, by means of whole cell catalysts and isolated enzymes.
Text in English.
9783527665785 3527665781 9783527665815 3527665811 9783527665808 3527665803 9783527665792 352766579X 9781299830240 1299830242
514275 MIL
Reduction (Chemistry)
Bioactive compounds--Synthesis.
Enzymes--Biotechnology.
Enzymes--Industrial applications.
SCIENCE--Physics--Crystallography.
Biochemistry.
Biomolecules.
Electronic books.
QD461
548.478
Includes bibliographical references and index.
Development of Sustainable Biocatalytic Reduction Processes for Organic Chemists / Roland Wohlgemuth -- Reductases: From Natural Diversity to Established Biocatalysis and to Emerging Enzymatic Activities / Elena Fernández-Álvaro, Pablo Domínguez de María -- Synthetic Strategies Based on C=C Bioreductions for the Preparation of Biologically Active Molecules / Francesco G Gatti, Fabio Parmeggiani, Alessandro Sacchetti -- Synthetic Strategies Based on C=O Bioreductions for the Preparation of Biologically Active Molecules / Aníbal Cuetos, Alba Díaz-Rodríguez, Iván Lavandera -- Protein Engineering: Development of Novel Enzymes for the Improved Reduction of C=C Double Bonds / Sabrina Kille, Manfred T Reetz -- Protein Engineering: Development of Novel Enzymes for the Improved Reduction of C=O Double Bonds / Nobuya Itoh, Yoshihide Makino -- Synthetic Applications of Aminotransferases for the Preparation of Biologically Active Molecules / Sachin Pannuri, Sanjay Kamat, Abraham R Mártin-García -- Strategies for Cofactor Regeneration in Biocatalyzed Reductions / Selin Kara, Joerg H Schrittwieser, Frank Hollmann -- Solvent Effects in Bioreductions / Yan Ni, Hui-Lei Yu, Jian-He Xu -- Application of Product Removal (ISPR) Technologies for Implementation and Scale-Up of Biocatalytic Reductions / John M Woodley -- Bioreductions in Multienzymatic One-Pot and Cascade Processes / Daniela Monti, Erica E Ferrandi -- Dynamic Kinetic Resolutions Based on Reduction Processes / Dimitris Kalaitzakis, Ioulia Smonou -- Relevant Practical Applications of Bioreduction Processes in the Synthesis of Active Pharmaceutical Ingredients / Gábor Tasnádi, Mélanie Hall.
This ready reference focuses on the currently available toolbox of biocatalysed reductions of C=O, C=C and formal C=N double bonds to show which transformations are reliable for use in manufacturing processes and which still require improvements and investigation. Following an introductory chapter, chapters 2-4 present the synthetic strategies which are currently available for the reduction of C=C, C=O and for reductive amination, by means of whole cell catalysts and isolated enzymes.
Text in English.
9783527665785 3527665781 9783527665815 3527665811 9783527665808 3527665803 9783527665792 352766579X 9781299830240 1299830242
514275 MIL
Reduction (Chemistry)
Bioactive compounds--Synthesis.
Enzymes--Biotechnology.
Enzymes--Industrial applications.
SCIENCE--Physics--Crystallography.
Biochemistry.
Biomolecules.
Electronic books.
QD461
548.478