Epigenomics in health and disease / [electronic resource]
edited by Mario F. Fraga and Agustin F. Fernandez.
- London : Academic Press, 2015, �2016.
- 1 online resource.
- Translational epigenetics series .
- Translational epigenetics series. .
Includes index.
Includes bibliographical references at the end of each chapters and index.
The role of the genetic code in the DNA methylation landscape formation / DNA methylation microarrays / Ultra-deep sequencing of bisulfite-modified DNA / Bioinformatics tools in epigenomics studies / Noncoding RNA regulation of health and disease / Genome-wide DNA methylation changes during aging / The dynamics of histone modifications during aging / Epigenomic studies in epidemiology / The DNA methylomes of cancer / Genome-wide epigenetic studies in neurologic diseases / Epigenetic deregulation in autoimmune disease / Genome-wide DNA and histone modification studies in metabolic disease / Clinical applications of epigenomics / Holger Heyn -- Marina Bibikova -- Tingting Qin, Yongseok Park, Maria E. Figueroa and Maureen A. Sartor -- Gustavo F. Bay�on, August�in F. Fern�andez and Mario F. Fraga -- Nicolas L�eveill�e, Carlos A. Melo and Sonia A. Melo -- Kevin C. Johnson and Brock C. Christensen -- Anthony J Bainor and Gregory David -- Valentina Bollati, Valeria Motta, Simona Iodice and Michele Carugno -- Ren�ee Beekman, Marta Kulis and Jos�e Ignacio Mart�in-Subero -- Ashwin Woodhoo -- Damiana �Alvarez-Errico and Esteban Ballestar -- Charlotte Ling and Tina R�onn -- Michael A. McDevitt.
Reviews the technologically-driven study of the oganismal epigenome and associated translational impacts on future prognosis, diagnosis and therapies of disease. With next-generation sequencing technologies shaping our current knowledge of the role of epigenetics in normal development, aging, and disease, Epigenomics in Health and Disease discusses the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. Chapters also explore the latest findings of epigenome-wade research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories. With coverage pertinent both to basic biology and translational research, Epigenomics in Health and Disease will be of particular interest for medical and bioscience researches and students seeking current translational knowledge in epigenesis and epigenomics. Key Features Critical reviews provide the means for reviewing and analyzing the epigenome as a whole as well as its translational potential Combines basic epigenomic knowledge with methodological and biostatistical topics related to technology and date analysis Includes coverage of relatively new topics including DNA methylation dynamics during development and differentiation, genome-wide histone post-translational modifications during development and differentiation, and genome-wide DNA methylation changes during aging.
0128004967 9780128004968 0128001402 9780128001400
9780128001400
017595343 Uk
Epigenetics.
Medical genetics.
SCIENCE--Life Sciences--Evolution.
Epigenetics.
Medical genetics.
Epigenomics--methods.
Epigenesis, Genetic.
Gene Expression Regulation.
Electronic books.
Electronic books.
QH450
576.5
QU 460
Includes index.
Includes bibliographical references at the end of each chapters and index.
The role of the genetic code in the DNA methylation landscape formation / DNA methylation microarrays / Ultra-deep sequencing of bisulfite-modified DNA / Bioinformatics tools in epigenomics studies / Noncoding RNA regulation of health and disease / Genome-wide DNA methylation changes during aging / The dynamics of histone modifications during aging / Epigenomic studies in epidemiology / The DNA methylomes of cancer / Genome-wide epigenetic studies in neurologic diseases / Epigenetic deregulation in autoimmune disease / Genome-wide DNA and histone modification studies in metabolic disease / Clinical applications of epigenomics / Holger Heyn -- Marina Bibikova -- Tingting Qin, Yongseok Park, Maria E. Figueroa and Maureen A. Sartor -- Gustavo F. Bay�on, August�in F. Fern�andez and Mario F. Fraga -- Nicolas L�eveill�e, Carlos A. Melo and Sonia A. Melo -- Kevin C. Johnson and Brock C. Christensen -- Anthony J Bainor and Gregory David -- Valentina Bollati, Valeria Motta, Simona Iodice and Michele Carugno -- Ren�ee Beekman, Marta Kulis and Jos�e Ignacio Mart�in-Subero -- Ashwin Woodhoo -- Damiana �Alvarez-Errico and Esteban Ballestar -- Charlotte Ling and Tina R�onn -- Michael A. McDevitt.
Reviews the technologically-driven study of the oganismal epigenome and associated translational impacts on future prognosis, diagnosis and therapies of disease. With next-generation sequencing technologies shaping our current knowledge of the role of epigenetics in normal development, aging, and disease, Epigenomics in Health and Disease discusses the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. Chapters also explore the latest findings of epigenome-wade research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories. With coverage pertinent both to basic biology and translational research, Epigenomics in Health and Disease will be of particular interest for medical and bioscience researches and students seeking current translational knowledge in epigenesis and epigenomics. Key Features Critical reviews provide the means for reviewing and analyzing the epigenome as a whole as well as its translational potential Combines basic epigenomic knowledge with methodological and biostatistical topics related to technology and date analysis Includes coverage of relatively new topics including DNA methylation dynamics during development and differentiation, genome-wide histone post-translational modifications during development and differentiation, and genome-wide DNA methylation changes during aging.
0128004967 9780128004968 0128001402 9780128001400
9780128001400
017595343 Uk
Epigenetics.
Medical genetics.
SCIENCE--Life Sciences--Evolution.
Epigenetics.
Medical genetics.
Epigenomics--methods.
Epigenesis, Genetic.
Gene Expression Regulation.
Electronic books.
Electronic books.
QH450
576.5
QU 460