Handbook of the biology of aging / (Record no. 247142)
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| control field | ocn919087033 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20190328114812.0 |
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| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cnu|||unuuu |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150824t20162016ne a ob 001 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | N$T |
| Language of cataloging | eng |
| Description conventions | rda |
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| Transcribing agency | N$T |
| Modifying agency | YDXCP |
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| 016 7# - NATIONAL BIBLIOGRAPHIC AGENCY CONTROL NUMBER | |
| Record control number | 101671936 |
| Source | DNLM |
| 019 ## - | |
| -- | 923546172 |
| -- | 929142666 |
| -- | 937530114 |
| -- | 1066627783 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780124116207 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 0124116205 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 0124115969 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780124115965 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 9780124115965 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 0124115969 |
| 024 3# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 9780124116207 |
| 024 3# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 9780124115965 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)919087033 |
| Canceled/invalid control number | (OCoLC)923546172 |
| -- | (OCoLC)929142666 |
| -- | (OCoLC)937530114 |
| -- | (OCoLC)1066627783 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QP86 |
| 060 00 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER | |
| Classification number | WT 104 |
| Item number | H236 2016 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | SCI |
| Subject category code subdivision | 056000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 571.8/78 |
| Edition number | 23 |
| 245 00 - TITLE STATEMENT | |
| Title | Handbook of the biology of aging / |
| Medium | [electronic resource] |
| Statement of responsibility, etc. | edited by Matt R. Kaeberlein and George M. Martin. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 8th ed. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Amsterdam : |
| Name of producer, publisher, distributor, manufacturer | Elsevier Ltd., |
| Date of production, publication, distribution, manufacture, or copyright notice | 2016. |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | �2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (xvi, 559 pages) : |
| Other physical details | illustrations. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 490 1# - SERIES STATEMENT | |
| Series statement | Handbooks of aging ; |
| Volume/sequential designation | volume 3 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc | Includes bibliographical references and indexes. |
| 588 0# - SOURCE OF DESCRIPTION NOTE | |
| Source of description note | Online resource; title from PDF title page (EBSCO, viewed August 26, 2015). |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | ""Front Cover""; ""Handbook of the Biology of Aging""; ""Copyright Page""; ""Contents""; ""Foreword""; ""Preface""; ""About the Editors""; ""List of Contributors""; ""I. Basic Mechanisms of Aging: Models and Systems""; ""1 Longevity as a Complex Genetic Trait""; ""Introduction""; ""Defining the Aging Gene-Space""; ""Direct Screens for Genetic Longevity Determinants""; ""RNAi Screens in Nematodes""; ""Knockout Screens in Budding Yeast""; ""Overexpression Screens in Fruit Flies""; ""Leveraging Genetic Diversity to Identify Aging Loci""; ""Mapping Longevity Genes in Human Populations"" |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | ""Mapping Longevity Genes in Mouse Populations""""Mouse�a�?Human Concordance""; ""Age-Associated Gene Expression Studies""; ""Non-Genetic Sources of Complexity""; ""Tissue-Specific Aging""; ""Tissue-Specific Age-Related DNA Methylation""; ""Telomere Shortening and Telomerase""; ""Tissue-Specific Responses of Aging Pathways""; ""Gene�a�?Environment Interaction""; ""Genetic Response to DR""; ""DR: Quantity, Composition, and Timing""; ""Environmental Temperature""; ""Environmental Oxygen and the Hypoxic Response""; ""Other Environmental Factors That Influence Aging"" |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | ""Emerging Tools for Studying Aging as a Complex Genetic Trait""""High-Throughput Lifespan Assays in Yeast and Worms""; ""Genome-Scale Mouse Knockout Collection""; ""Collaborative Cross and Diversity Outbred Mice""; ""Expression QTLs""; ""Aging Biomarkers""; ""Conclusions""; ""References""; ""2 The mTOR Pathway and Aging""; ""Introduction""; ""mTOR Signaling Pathway""; ""Molecular Composition of mTOR Complex""; ""Upstream Regulators of mTOR Complexes""; ""Substrates and Actions of mTORC1""; ""Substrates and Actions of mTORC2"" |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | ""Genetic Modulation of Longevity by TOR Signaling in Model Organisms""""Rapamycin""; ""Rapalogs""; ""Potential Mechanisms of Life Span Extension by mTOR Inhibition""; ""Translation""; ""Autophagy""; ""Anticancer Effect""; ""Stem Cell Maintenance""; ""mTOR in Age-Related Diseases""; ""Cancer""; ""Metabolic Disease""; ""Cardiovascular""; ""Neurodegeneration and Cognitive Decline""; ""Immune Response""; ""Conclusion""; ""References""; ""3 Sirtuins, Healthspan, and Longevity in Mammals""; ""Introduction""; ""Sirtuin-Driven Lifespan Extension in Invertebrates""; ""Sirtuin Enzymatic Activity"" |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | ""Sirtuins and Mammalian Longevity""""SIRT1""; ""SIRT2""; ""SIRT6""; ""Genetic Variation of Human Sirtuins""; ""SIRT1""; ""SIRT3""; ""Sirtuins as Modulators of Responses to CR""; ""SIRT1""; ""SIRT2""; ""SIRT3""; ""SIRT4""; ""SIRT5""; ""SIRT6""; ""Roles for Sirtuins in Diverse Disease States""; ""Cancer""; ""SIRT1""; ""SIRT2""; ""SIRT3""; ""SIRT4""; ""SIRT6""; ""SIRT7""; ""Metabolic Syndrome""; ""SIRT1""; ""SIRT2""; ""SIRT3""; ""SIRT4""; ""SIRT5""; ""SIRT6""; ""SIRT7""; ""Cardiovascular Dysfunction""; ""SIRT1""; ""Other Sirtuins""; ""Inflammatory Signaling""; ""Neurodegenerative Disease"" |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussion. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc | Includes bibliographical references and index. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Aging |
| General subdivision | Physiological aspects. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Aging |
| General subdivision | physiology. |
| Authority record control number | (DNLM)D000375Q000502 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | SCIENCE |
| General subdivision | Life Sciences |
| -- | Anatomy & Physiology. |
| Source of heading or term | bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Aging |
| General subdivision | Physiological aspects. |
| Source of heading or term | fast |
| Authority record control number | (OCoLC)fst00800323 |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 655 #0 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic book. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kaeberlein, Matt, |
| Dates associated with a name | 1971- |
| Relator term | editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Martin, George M., |
| Dates associated with a name | 1927- |
| Relator term | editior. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Print version: |
| Main entry heading | Kaeberlein, Matt. |
| Title | Handbook of the Biology of Aging. |
| Place, publisher, and date of publication | : Elsevier Science, �2015 |
| International Standard Book Number | 9780124115965 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Handbooks of aging ; |
| Volume number/sequential designation | v. 3. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Materials specified | ScienceDirect |
| Uniform Resource Identifier | http://www.sciencedirect.com/science/book/9780124115965 |
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