Includes bibliographical references and index.

Frontmatter -- Color Plates -- Introduction. Why are we Interested in the Unfolded Peptides and Proteins? / Vladimir N Uversky, A Keith Dunker -- Conformational Analysis of Unfolded States. Exploring the Energy Landscape of Small Peptides and Proteins by Molecular Dynamics Simulations / Gerhard Stock, Abhinav Jain, Laura Riccardi, Phuong H Nguyen -- Local Backbone Preferences and Nearest-Neighbor Effects in the Unfolded and Native States / Joe DeBartolo, Abhishek Jha, Karl F Freed, Tobin R Sosnick -- Short-Distance FRET Applied to the Polypeptide Chain / Maik H Jacob, Werner M Nau -- Solvation and Electrostatics as Determinants of Local Structural Order in Unfolded Peptides and Proteins / Franc Avbelj -- Experimental and Computational Studies of Polyproline II Propensity / W Austin Elam, Travis P Schrank, Vincent J Hilser -- Mapping Conformational Dynamics in Unfolded Polypeptide Chains Using Short Model Peptides by NMR Spectroscopy / Daniel Mathieu, Karin Rybka, Jurgen Graf, Harald Schwalbe -- Secondary Structure and Dynamics of a Family of Disordered Proteins / Pranesh Narayanaswami, Gary W Daughdrill -- Disordered Peptides and Molecular Recognition. Binding Promiscuity of Unfolded Peptides / Christopher J Oldfield, Bin Xue, A Keith Dunker, Vladimir N Uversky -- Intrinsic Flexibility of Nucleic Acid Chaperone Proteins from Pathogenic RNA Viruses / Roland Ivanyi-Nagy, Zuzanna Makowska, Jean-Luc Darlix -- Aggregation of Disordered Peptides. Self-Assembling Alanine-Rich Peptides of Biomedical and Biotechnological Relevance / Thomas J Measey, Reinhard Schweitzer-Stenner -- Structural Elements Regulating Interactions in the Early Stages of Fibrillogenesis: A Human Calcitonin Model System / Rosa Maria Vitale, Giuseppina Andreotti, Pietro Amodeo, Andrea Motta -- Solution NMR Studies of A Monomers and Oligomers / Chunyu Wang -- Thermodynamic and Kinetic Models for Aggregation of Intrinsically Disordered Proteins / Scott L Crick, Rohit V Pappu -- Modifiers of Protein Aggregation--From Nonspecific to Specific Interactions / Michal Levy-Sakin, Roni Scherzer-Attali, Ehud Gazit -- Computational Studies of Folding and Assembly of Amyloidogenic Proteins / J Srinivasa Rao, Brigita Urbanc, Luis Cruz -- Index.

"This book provides an overview on what researchers have learned about unfolded peptides and how this knowledge facilitates the understanding of (a) the folding process, (b) the binding of ligands to receptor molecules, and (c) peptide self-aggregation. In this context, different experimental, theoretical, and computational concepts and approaches are introduced. This book can become a very useful addition for graduate-level courses on protein folding for the education of undergraduate and graduate students in research groups, which are exploring peptide self-aggregation for biomedical and biotechnological purposes"-- Provided by publisher.

Print version record.