Includes bibliographical references and index.

Front Matter -- Deciphering DNA Sequence Information / Mark Kaganovich, Michael Snyder -- DNA Methylation / Carina Frauer, Fabio Spada, Heinrich Leonhardt -- Nucleosomes as Control Elements for Accessing the Genome / Mekonnen Lemma Dechassa, Karolin Luger -- Histone Modifications and Their Role as Epigenetic Marks / Karl Nightingale -- Chromatin Remodeling and Nucleosome Positioning / Gernot L̃ngst, Vladimir B Teif, Karsten Rippe -- The Folding of the Nucleosome Chain / Karsten Rippe -- The Crowded Environment of the Genome / Ron Hancock -- The Nuclear Lamina as a Chromatin Organizer / Nikolaj Zuleger, Eric C Schirmer -- Three-Dimensional Architecture of Genomes / Job Dekker -- Transcriptional Initiation: Frequency, Bursting, and Transcription Factories / Kieran Finan, Peter R Cook -- Processing of mRNA and Quality Control / Ute Schmidt, Edouard Bertrand -- The Nucleolus / Saskia Hutten, Belinda J Westman, Fraṅois-Michel Boisvert, Silvana van Koningsbruggen, Angus I Lamond -- Non-Coding RNAs as Regulators of Transcription and Genome Organization / Katalin Fejes T̤th, Gregory Hannon -- RNA Networks as Digital Control Circuits of Nuclear Functions / John S Mattick -- DNA Replication and Inheritance of Epigenetic States / Armelle Corpet, Genevïve Almouzni -- Interplay and Quality Control of DNA Damage Repair Mechanisms / Berina Eppink, Jeroen Essers, Roland Kanaar -- Higher Order Chromatin Organization and Dynamics / Hilmar Strickfaden, Thomas Cremer, Karsten Rippe -- The Mitotic Chromosome: Structure and Mechanics / John F Marko -- Meiotic Chromosome Dynamics / Nancy Kleckner, Liangran Zhang, Beth Weiner, Denise Zickler -- Understanding Genome Function: Quantitative Modeling of Chromatin Folding and Chromatin-Associated Processes / Mariliis Tark-Dame, Martijn S Luijsterburg, Dieter W Heermann, Roel van Driel -- Index.

By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gainedknowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair, recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions andnon-coding RNAs, chromatin structure, ep.