Includes index.

Includes bibliographical references and index.

Cirrhosis: A Practical Guide to Management; Contents; List of contributors; Foreword; List of abbreviations; Part 1: Diagnosis and pathophysiology; 1. Clinical clues to the diagnosis of cirrhosis; Introduction; Clinical presentation; Patient history; Abdominal distension (ascites); Jaundice; Upper gastrointestinal bleeding; Hepatic encephalopathy; Etiologic history taking; Alcohol intake: how much is significant; History of other risk factors; Examination; General examination; Nutritional status; Cutaneous clues; Spider angioma; Palmar erythema; Dupuytren's contracture; Leukonychia.

Muehrcke's nailsBier spots; Paper-money skin; Hypogonadism and gynecomastia; Parotidomegaly; Other manifestations; Abdominal examination; Abdominal veins; Cruveilhier-Baumgarten murmur; Examination of the liver; Examination of the spleen; Examination for ascites; Neurologic examination; References; 2. Diagnostic laboratory tests; Introduction; Tests that detects hepatic injury (Table 2.1); Serum aminotransferases; Serum biliary enzymes; Tests of hepatic metabolism (Table 2.1); Serum bilirubin; Serum ammonia; Indocyanine green and bromsulphalein tests.

Tests of hepatic biosynthetic function (Table 2.2)Serum albumin; Prothrombin time and international normalized ratio; Individual serum coagulating factor levels; Factor VIII; Factors V and VII; Cell counts and other biochemistry (Table 2.2); Thrombocytopenia; Neutropenia; Anemia; Globulins; Hyponatremia; Accuracy of routine laboratory investigations (Table 2.3); Combination indices or models for detecting cirrhosis (Table 2.4); Specific tests for determining the etiology of liver cirrhosis; Tests for viral hepatitis; Tests for alcoholic liver disease; Tests for primary biliary cirrhosis.

Tests for primary sclerosing cholangitisTests for hereditary hemochromatosis; Transferrin saturation; Plasma ferritin level; Tests for Wilson's disease; Serum ceruloplasmin; Serum copper; Urine copper excretion; Tests for alpha-1 antitrypsin deficiency; Conclusions; References; 3. Diagnostic imaging modalities; Ultrasonography-based approaches; Grayscale and Doppler US; Contrast-enhanced ultrasonography; Measurement of liver stiffness: transient elastography, acoustic radiation force impulse, supersonic shear-wave elastography, and real-time elastography; CT- and MRI-based approaches.

Morphologic changesHemodynamic changes; MR elastography; Other imaging techniques; References; 4. Histology/pathology; Introduction; Cirrhosis: a pathologic spectrum; Fibrosis: extracellular accumulation of matrix components; Vascular changes; Parenchymal nodules: etiologic features; Cirrhosis: an evolving concept; Cirrhosis: a preneoplastic condition; Cirrhosis: a place for biopsy?; References; 5. Fibrosis and fibrogenesis; Introduction; Mechanism of liver fibrosis in hepatitis B and C; Diagnosis of liver fibrosis by imaging; Diagnosis of liver fibrosis by laboratory tests.

Cirrhosis: a practical guide to management providesgastroenterologists and hepatologists with an up-to-date clinicalguide presenting the very best evidence-based practice in thediagnosis, treatment and management of liver cirrhosis and its manycomplications. Designed to offer practical guidance at alltimes, it provides doctors with an extremely useful tool in theclinical setting, with each chapter featuring diagnostic/managementalgorithms, key points and other pedagogic features. Divided into 2 parts, a diagnosis and pathophysiology section and amanagement of complications section, key topics.

Print version record and CIP data provided by publisher.