Cancer: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in cancer and then the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component of this. Oncologists, cancer researchers, and nutritionists are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While oncologists and cancer researchers may study the underlying pathogenesis of cancer, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of oncology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of cancer.

Print version record.

Includes bibliographical references at the end of each chapters and index.

Front Cover; Cancer: Oxidative Stress and Dietary Antioxidants; Copyright; Contents; Preface; List of Contributors; Section 1 -- OXIDATIVE STRESS AND CANCER; Chapter 1 -- The Role of Oxidative Stress in Breast Cancer; INTRODUCTION; OXIDATIVE STRESS AS A DRIVER OF BREAST CANCER DEVELOPMENT AND PROGRESSION; OXIDATIVE STRESS RESPONSE AND ADAPTATION MECHANISMS IN BREAST CANCER; INTERESTING FINDINGS, LIMITATIONS, AND FUTURE DIRECTIONS; CONCLUDING REMARKS; SUMMARY POINTS; Acknowledgements; References; Chapter 2 -- Oxidative Stress and Prostate Cancer; INTRODUCTION.

CAUSES OF OXIDATIVE STRESS IN PROSTATE CANCERROLE OF OXIDATIVE STRESS IN PATHOGENESIS OF PROSTATE CANCER; PROSTATE CANCER RISK FACTORS AND THEIR LINKS TO OXIDATIVE STRESS; CONCLUSIONS; SUMMARY POINTS; References; Chapter 3 -- Oxidative Stress in Lung Cancer; INTRODUCTION; LUNG CANCER; ETIOLOGY OF LUNG CANCER; TOBACCO SMOKING AND OXIDANTS; SILICA AND OXIDANTS; ASBESTOS AND OXIDANTS; DOMESTIC COOKING AND OXIDANTS; ROLE OF OXIDANTS IN NORMAL PHYSIOLOGY; INFLAMMATION AND OXIDATIVE STRESS; OXIDATIVE STRESS LEADS TO DNA MUTATIONS AND LUNG CANCER; LIPID AND PROTEIN PEROXIDATION.

OXIDANT/ANTIOXIDANT DISEQUILIBRIUMANTIOXIDANTS AND LUNG CANCER CHEMOPREVENTION; CONCLUSION; SUMMARY POINTS; References; Chapter 4 -- Oxidative Stress and Stomach Cancer; INTRODUCTION; H. PYLORI AND OXIDATIVE STRESS; ETHANOL; NONSTEROIDAL ANTI-INFLAMMATORY DRUGS AND ASPIRIN; ISCHEMIA/REPERFUSION INJURY; REACTIVE OXYGEN SPECIES; REACTIVE NITROGEN SPECIES; ANTIOXIDANTS AND STOMACH CANCER; CONCLUSION; SUMMARY POINTS; References; Chapter 5 -- The Role of Oxidative Stress in Ovarian Cancer: Implications for the Treatment of Patients; INTRODUCTION; OVARIAN BIOLOGY.

COMMON OVARIAN CANCER MUTATIONS LINKED TO ROSANTIOXIDANT MECHANISMS IN THE OVARY; ANTIOXIDANT THERAPIES, OVARIAN CANCER; CONCLUSION; SUMMARY POINTS; References; Chapter 6 -- Role of Oxidative Stress in Human Papillomavirus-Driven Cervical Carcinogenesis; INTRODUCTION; CERVICAL CANCER; HPV STRUCTURE; OXIDATIVE STRESS AND CERVICAL CANCER; CONCLUDING REMARKS; SUMMARY POINTS; References; Chapter 7 -- Inflammation and Oxidative DNA Damage: A Dangerous Synergistic Pathway to Cancer; INTRODUCTION; OXIDATIVE DNA DAMAGE.

ROLE OF INFLAMMATION IN INDUCTION OF OXIDATIVE STRESS AND DNA DAMAGE LEADING TO CANCERNONTARGETED EFFECTS, INFLAMMATION, OXIDATIVE STRESS AND DNA DAMAGE; RADIATION-INDUCED INFLAMMATION; CONCLUSION; SUMMARY POINTS; References; Section 2 -- ANTIOXIDANTS AND CANCER; Chapter 8 -- Molecular Approaches Toward Targeted Cancer Therapy with Some Food Plant Products: On the Role of Antioxidants; INTRODUCTION; OXIDATIVE STRESS AND REACTIVE OXYGEN SPECIES (ROS): THE "RUSTING DISORDER"; OXIDATIVE STRESS: DEFINITION, SOURCES, AND CHEMISTRY IN GENERAL; CANCER: DEFINITION AND THE IMPACT OF FOOD AND FOOD HABITS.

English.