Front Cover; Transgenerational Epigenetics: Evidence and Debate; Copyright; Contents; Preface; Contributors; Chapter 1 -- Transgenerational Epigenetics; INTRODUCTION; DEFINITION AND HISTORY OF GENERATIONAL EPIGENETIC INHERITANCE; GERMLINE EPIGENETICS; EPIDEMIOLOGY OF EPIGENETIC INHERITANCE; BASIC MECHANISMS/PROCESSES OF EPIGENETIC INHERITANCE; MODEL ORGANISMS; EVOLUTION OF TRANSGENERATIONAL EPIGENETICS; PARENTAL EPIGENETIC INHERITANCE; ENVIRONMENTAL EPIGENETIC EFFECTS ON THE OFFSPRING; IMPACT OF TRANSGENERATIONAL EPIGENETICS ON DISEASE; CLINICAL SIGNIFICANCE OF TRANSGENERATIONAL EPIGENETICS

CONTROVERSIES AND DEBATE OF GENERATIONAL EPIGENETIC INHERITANCECONCLUSION; REFERENCES; Section I -- Definitions and History of Generational Epigenetic Inheritance; Chapter 2 -- Definition of Epigenetic Transgenerational Inheritance and Biological Impacts; INTRODUCTION AND HISTORICAL CONTEXT; EPIGENETIC TRANSGENERATIONAL INHERITANCE; GERMLINE EPIMUTATIONS; TRANSGENERATIONAL INHERITANCE OF DISEASE AND PHENOTYPIC VARIATION; TRANSGENERATIONAL DISEASE ETIOLOGY; IMPACT AND FUTURE STUDIES; REFERENCES; Chapter 3 -- Historical Perspective of Transgenerational Epigenetics; INTRODUCTION

SHIFTING PARADIGMS OF HEREDITY AND EVOLUTIONEARLY EVIDENCE OF NON-MENDELIAN INHERITANCE; THE ORIGINS OF EPIGENETICS; INTERSECTION OF PHENOMENA AND MECHANISMS; TRANSGENERATIONAL EPIGENETICS IN ECOLOGY AND PHYSIOLOGY; CONCLUSION; REFERENCES; Section II -- Germline Epigenetics; Chapter 4 -- Epigenetics and the Maternal Germline; INTRODUCTION; TRANSGENERATIONAL INHERITANCE IN THE MATERNAL GERMLINE; DISCUSSION; FUTURE DIRECTIONS; ACKNOWLEDGMENTS; REFERENCES; Chapter 5 -- Epigenetic Changes in the Paternal Germline; INTRODUCTION; PGC EPIGENETIC REPROGRAMMING; EPIGENETICS OF MEIOTIC PROPHASE I

HISTONE-TO-PROTAMINE TRANSITION DURING SPERMIOGENESISZYGOTIC EPIGENETIC REPROGRAMMING; TRANSGENERATIONAL EPIGENETIC INHERITANCE, AGING, AND ENVIRONMENTAL EFFECTS; EPIGENETICS IN MALE-FACTOR INFERTILITY; CONCLUSIONS; REFERENCES; Section III -- Epidemiology of Epigenetic Inheritance; Chapter 6 -- Epidemiology of Transgenerational Epigenetics; INTRODUCTION; THE EVIDENCE FOR TRANSGENERATIONAL EPIGENETICS IN HUMANS; POTENTIAL MECHANISMS OF TRANSGENERATIONAL TRANSMISSION: TRANSGENERATIONAL EPIGENETIC INHERITANCE; SUMMARY; REFERENCES; Section IV -- Basic Mechanisms/Processes of Epigenetic Inheritance

Chapter 7 -- Metastable EpiallelesDEFINITIONS; MURINE MES; HUMAN ME CANDIDATES; POTENTIAL FOR THE TRANSGENERATIONAL INHERITANCE OF MES; REFERENCES; Chapter 8 -- Towards the Molecular Mechanisms of Transgenerational Epigenetic Inheritance: Insights from Transgenic Mice; INTRODUCTION; TEI IN CLASSICAL TRANSGENES: HERITABLE TRANSCRIPTION SILENCING; POTENTIAL MECHANISMS OF TEI AT THE CLASSICAL TRANSGENES; INSIGHTS FROM INDUCIBLE MOUSE MODELS: TIMING IS EVERYTHING FOR MITOTIC INHERITANCE, BUT LOCATION IS ALSO CRUCIAL FOR TEI; CONCLUSIONS AND FUTURE PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES

Chapter 9 -- Histone-Mediated Transgenerational Epigenetics

Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes. Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a numb

Print version:: Tollefsbol, Trygve: Transgenerational Epigenetics

Includes bibliographical references at the end of each chapters and index.