Includes index.

Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry. The elucidation of basic principles o.

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Front Cover; Epigenetics in Psychiatry; Copyright Page; Contents; Preface; About the Editors; List of Contributors; 1 General Aspects of Epigenetics in Psychiatry; 1 Introduction to Epigenetics in Psychiatry; Introduction; Genetics of psychiatric disorders; Schizophrenia; Autism spectrum disorder; Bipolar disorder; Major depressive disorder; Attention deficit hyperactivity disorder; Genotype versus phenotype; Missing heritability; Epigenetics in psychiatric disorders; Nutrition; Prenatal infection; Stress; Epigenetic versus genetic approaches to psychiatric disorders.

Moving epigenetics forwardConclusion; References; Glossary; 2 Outline of Epigenetics; Introduction; Molecular mechanisms of epigenetics; DNA methylation; DNA methylation, development, and disease; Chromatin remodeling and histone modifications; Histone acetylation; Histone methylation; Other histone modifications; Non-Coding RNA; microRNA; Correlation of epigenetics with genetics, transcriptomics, and proteomics; Clinical and medical implication of epigenetics; Conclusion; Acknowledgments; References; Glossary; 3 A Brief History of Epigenetics in Psychiatry; Introduction.

Erikson's epigenetic principleSchizophrenia: the epigenetic puzzle; Later theoretical developments; Experimental (laboratory) studies on epigenetics in psychiatry; The social environment and epigenetics in psychiatry; Conclusions; References; Glossary; 4 Roles of Epigenetics in the Neural Stem Cell and Neuron; Outline of neural cell production during cortical development; Epigenetic regulation of exit from cell proliferation cycle toward postmitotic neurons during early cortical development.

Epigenetic regulation underlying properties of multipotent neural stem cells and their differentiation into upper layer cor ... Epigenetic regulation of postnatal oligodendrocyte differentiation and adult neurogenesis; Combination of trans-acting epigenetic modifiers involved in epigenome formation; Importance of focusing on epigenetics in neuronal functions; Impact of epigenetic regulation on synaptic plasticity, learning, and memory; Plasticity of epigenetic profile in neurons in response to extrinsic stimuli; The robust identity of neurons defined by the epigenetic status.

Concluding remarksAcknowledgments; References; Glossary; 5 Role of Epigenetics in the Brain; Introduction; Role of epigenetics in evolution; Role of epigenetics in brain development; Brain development; Epigenetics in early brain development; Epigenetics in adult neurogenesis and later brain maturation; Epigenetics and extrinsic factors regulating brain development; Role of epigenetic mechanisms in brain function; Epigenetics and memory; Epigenetics and stress; Epigenetics and cognitive dysfunction; Concluding remarks; Acknowledgments; References; Glossary.