Transporters in drug discovery and development : detailed concepts and best practice / [electronic resource]
by Lai, Yurong.
Material type:
BookSeries: Woodhead Publishing series in biomedicine: Publisher: Oxford : Elsevier Science, 2013Description: 1 online resource (xxiii, 734 pages) : illustrations.ISBN: 9781908818287; 190881828X.Subject(s): Biopharmaceutics | Drug development | Drugs -- Design | MEDICAL -- Pharmacology | Biopharmaceutics | Drug development | Drugs -- Design | Electronic booksOnline resources: ScienceDirect Includes bibliographical references and index.
Print version of record.
Membrane transporters and the diseases corresponding to functional defects -- P-glycoprotein (P-gp/MDR1)/ABCB1 -- Multidrug resistanceassociated protein 2 (MRP2/ABCC2) -- Breast cancer resistance protein (BCRP)/ABCG2 -- The bile salt export pump (BSEP/ABCB11) -- Organic aniontransporting polypeptides (OATPs/SLCOs) -- Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs) -- Drug transporters in drug discovery and development -- 9 Transporter study methodologies.
Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery.
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