Includes bibliographical references at the end of each chapters and index.

Online resource; title from PDF title page (ebrary, viewed September 13, 2014).

FrontCover; Principles of Developmental Genetics; Copyright; Contents; Preface; Developmental Genetics: An Historical Perspective; RECOMMENDED RESOURCES; Contributors; Section I -- Emerging Technologiesand Systems Biology; Chapter 1 -- Generating Diversity and Specificity through Developmental Cell Signaling; SUMMARY; 1.1 INTRODUCTION; 1.2 IDENTIFICATION OF SIGNALING PATHWAY COMPONENTS; 1.3 FUNCTIONAL DIVERSIFICATION OF RELATED SIGNALING PROTEINS; 1.4 ROLES OF CYTOPLASMIC EXTENSIONS IN CELL SIGNALING; 1.5 FORMATION AND INTERPRETATION OF SIGNALING GRADIENTS.

1.6 TRANSCRIPTIONAL REGULATION BY DEVELOPMENTAL CELL SIGNALING PATHWAYS1.7 TRANSCRIPTION-INDEPENDENT RESPONSES TO CELL SIGNALING; 1.8 ROLES OF COMPUTATIONAL BIOLOGY IN DEVELOPMENTAL CELL SIGNALING STUDIES; 1.9 CLOSING REMARKS; 1.10 CLINICAL RELEVANCE: DEVELOPMENTAL CELL SIGNALING AND HUMAN DISEASE; ACKNOWLEDGMENTS; REFERENCES; Chapter 2 -- Applications of Deep Sequencing to Developmental Systems; SUMMARY; 2.1 INTRODUCTION; 2.2 USING RNA-SEQ TO MAP AND QUANTIFY TRANSCRIPTS; 2.3 CHROMATIN IMMUNOPRECIPITATION FOR IDENTIFYING PROTEIN-DNA INTERACTIONS.

2.4 DNASE I HYPERSENSITIVE SITE MAPPING TO IDENTIFY CIS-REGULATORY REGIONS2.5 INTERACTIONS AT A DISTANCE; 2.6 PROSPECTS; 2.7 CLINICAL RELEVANCE; RECOMMENDED RESOURCES; REFERENCES; Chapter 3 -- Using Mutagenesis in Mice for Developmental Gene Discovery; SUMMARY; 3.1 USE OF ENU AS A MUTAGEN; 3.2 ENU-INDUCED MUTATIONS IN MICE; 3.3 ENU-INDUCED MUTATIONS AFFECTING DEVELOPMENT; 3.4 IDENTIFICATION OF MODIFIER LOCI; 3.5 CLINICAL RELEVANCE; RECOMMENDED RESOURCES; REFERENCES; Chapter 4 -- Chemical Approaches to Controlling Cell Fate; SUMMARY; 4.1 INTRODUCTION.

4.2 CHEMICAL APPROACHES TO CONTROLLING CELL FATE4.3 CLINICAL RELEVANCE; ACKNOWLEDGMENT/GRANT SUPPORT; RECOMMENDED RESOURCES; Web sites; Reviews; REFERENCES; Chapter 5 -- BMP Signaling and Stem Cell Self-Renewal in the Drosophila Ovary; SUMMARY; 5.1 INTRODUCTION; 5.2 THE DROSOPHILA OVARY; 5.3 THE BMP SIGNALING PATHWAY; 5.4 REGULATION OF BMP SIGNALING BY EXTRINSIC FACTORS; 5.5 REGULATION OF BMP SIGNALING BY INTRINSIC FACTORS; 5.6 ADDITIONAL REGULATORS; 5.7 SELECTED TOPICS; 5.8 BMP SIGNALING AND STEM CELL HOMEOSTASIS IN VERTEBRATES; 5.9 CONCLUSIONS; 5.10 CLINICAL RELEVANCE; RECOMMENDED RESOURCES.

PublicationsWebsites; REFERENCES; Chapter 6 -- Genomic Analyses of Neural Stem Cells; SUMMARY; 6.1 INTRODUCTION; 6.2 THE IMPORTANCE OF GLOBAL ANALYSIS AND CAVEATS WHEN COMPARING CELL SAMPLES; 6.3 THE USE OF A REFERENCE STANDARD; 6.4 EPIGENETIC MODULATION; 6.5 MICRORNA; 6.6 MITOCHONDRIAL SEQUENCING; 6.7 TRANSCRIPTOME MAPPING; 6.8 DATA MINING: CHROMOSOME MAPPING, PATHWAY ANALYSIS, DATA REPRESENTATION; 6.9 GENERAL OBSERVATIONS ABOUT THE PROPERTIES OF NEURAL STEM CELLS; 6.10 SPECIES DIFFERENCES; 6.11 LACK OF A "STEMNESS" PHENOTYPE; 6.12 ALLELIC VARIABILITY; 6.13 AGE DEPENDENT CHANGES IN NSCS.

Providing expert coverage of all major events in early embryogenesis and the organogenesis of specific systems, and supplemented with representative clinical syndromes, Principles of Developmental Genetics, Second Edition discusses the processes of normal development in embryonic and prenatal animals, including humans. The new edition of this classic work supports clinical researchers developing future therapies with its all-new coverage of systems biology, stem cell biology, new technologies, and clinical disorders. A crystal-clear layout, exceptional full-color design, and bulleted summaries.

English.