Includes index.

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Front Cover; Hybrid Retrosynthesis; Copyright Page; Contents; Preface; Common Abbreviations; Summary of Reactions in Chapter 8; 1 Disconnections and Synthesis; 1.A The Disconnection Approach; 1.B Functional Group Exchange Reactions; 2 Making Carbon-Carbon Bonds; 3 Computer-Assisted Syntheses; 4 A Hybrid Retrosynthesis Approach; 5 Creative Strategies to Searching for Reagents; 6 Stereochemistry; 7 Molecules of Greater Complexity; 7.A Convergent Syntheses; 7.B Perovskone; 7.C Amphotericin B; 7.D Carbovir; 8 Common Fundamental Reactions in Organic Chemistry.

8.A Functional Group Exchange ReactionsAcetals and Ketals; 1 From Aldehydes or Ketones; Acid Chlorides; 2 From Carboxylic Acids; Alcohols; 3 From Acid Derivatives (acid chlorides, anhydrides, esters); 4 From Alkenes; 5 From Ethers; 6 From Ketones or Aldehydes; Alcohol-Alcohol; Alcohols-Functionalized; 7 From Epoxides or Alkenes; Aldehydes or Ketones; 8 From Acetals; 9 From Alcohols; 10 From Alkenes; 11 From Alkynes; 12 From Diols; 13 From Nitriles; Alkanes; 14 From Alkenes; 15 From Alkyl Halides; 16 From Ketones or Aldehydes; Alkenes; 17 From Alkynes.

18 From Halides, Sulfonate Esters, or Ammonium SaltsAlkyl Halides; Alkynes; 19 From Alkenyl Halides; Amides; 20 From Acid Derivatives; 21 From Nitriles; Amines; 22 From Azides, Imides, and Halides; 23 From Nitriles; 24 From Nitro Compounds; Anhydrides; 25 From Carboxylic Acids and Acid Derivatives; Aryl Halides; Carboxylic Acids; 26 From Acid Derivatives (acid chlorides, anhydrides, esters, amides); 27 From Alcohols; 28 From 1,3-Dicarboxylic Acids; 29 From Nitriles; Dienes; 30 From Aromatics; Dihalides; Diols; 31 From Alkenes; 32 From Epoxides; Enamines; 33 From Ketones or Aldehydes; Epoxides.

34 From Alkenes35 From Halohydrins; Esters; 36 From Carboxylic Acids and Acids Derivatives; 37 From Ketones; Ethers; 38 From Alcohols; Halides (Alkyl); 39 From Alcohols; 40 From Alkanes and Aryls; 41 From Alkenes; 42 From Alkyl Halides; Halides (Alkenyl); 43 From Alkynes; Imines; 44 From Ketones or Aldehydes; Ketals; Ketones or Aldehydes. See Aldehydes; 45 From Alkynes; 46 From Diols; 47 From Ketone-Acids; Nitriles; 48 From Amides; Nitro Compounds; 49 From Aromatics; Organometallics; 50 From Alkyl Halides; Phenols; 51 From Aryl Halides; Phosphonium Salts; 52 From Alkyl Halides; Sulfonic Acids.

53 From Aromatics8.B Carbon-Carbon Bond Forming Reactions; Alcohols; 54 From Acid Derivatives and Organometallics; 55 From Epoxides; 56 From Ketones or Aldehydes and Organometallics; Alcohols-Esters; 57 From Esters; Alcohol-Ketones; Aldehydes and Ketones; 58 From Aldehydes or Ketones and Alkyl Halides; 59 From Organometallics and Dimethylformamide (DMF); Aldehyde-Alkenes; 60 From Allylic Vinyl Ethers; Alkanes; 61 From Alkenes; 62 From Alkyl Halides and Organometallics; Alkenes; 63 From Alkenes and Aryl Halides (Heck reaction); 64 From Alkenes and Dienes; 65 From Dienes.

Organic Synthesis and Retrosynthesis: An Applied Approach provides readers with the essential skills they need for both organic synthesis and retrosynthesis, encouraging their practice in real-life problems included within the text. It is designed to supplement existing organic textbooks, not only providing a refresher on organic chemistry, but also taking the subject one-step further by including practical applied examples to try in Reaxys (www.reaxys.com). In addition, the text provides new, applied skills and tools to help users during organic synthesis courses, and is also useful fo.