Advanced Mechanical Models of DNA Elasticity includes coverage on 17 different DNA models and the role of elasticity in biological functions with extensive references. The novel advanced helicoidal model described reflects the direct connection between the molecule helix structure and its specific properties, including nonlinear features and transitions. It provides an introduction to the state of the field of DNA mechanics, known and widely used models with their short analysis, as well as coverage on experimental methods and data, the influence of electrical, magnetic, ionic conditions on the persistence length, and dynamics with viscosity influence. It then addresses the need to understand the nature of the non-linear overstretching transition of DNA under force and why DNA has a negative twist-stretch coupling.

Includes index.

Online resource; title from PDF title page (ScienceDirect, viewed April 20, 2016).

Includes bibliographical references and index.

Cover; Title Page; Copyright Page; Dedication; Contents; Biography; Preface; Acknowledgments; Chapter 1 -- DNA Molecules Mechanical Properties and Models; 1.1 -- Mechanical properties; 1.2 -- Discrete, flexible chains, and atomistic models: WLC, FJC, DPC, WLRC, HW, ZZM; 1.3 -- Continuum and approximation models; 1.4 -- Dynamics and fluctuation; 1.5 -- Persistence length features; 1.6 -- A, B, Z DNA forms, S- and P-DNA phases; 1.7 -- Polymer materials; 1.8 -- DNA technical applications; 1.9 -- DNA size and mass conversion; 1.10 -- Deflection at equilibrium; References.

Chapter 2 -- Force Application, Measurement, and Manipulation Accessories2.1 -- Stretching micropipette, glass microneedles, and hydrodynamics; 2.2 -- Optical trap and tweezers; 2.2.1 -- The Radiation Pressure of Light; 2.2.2 -- Experimental Test; 2.3 -- Small-angle X-ray scattering interference (SAXSI); 2.4 -- Magnetic tweezers; 2.4.1 -- Magnetic Influence Field; 2.4.2 -- Magnetostriction; 2.5 -- Atomic force microscopy; 2.5.1 -- Micro-Nano-Cantilevers; 2.5.2 -- Cantilever Preferred Shape; 2.5.3 -- Effective Mass Factor; 2.5.4 -- The Largest Attainable Natural Frequencies; 2.5.5 -- Spring Constants.

2.5.6 -- AFM Dynamics Parameters2.5.7 -- Contact Dynamics of Tapping Mode; 2.5.8 -- Nanocontact Mechanics in Manipulation; 2.6 -- Concave notch hinges; 2.6.1 -- Inverse Conformal Mapping of Approximating Contour; 2.6.2 -- Circular Notch Hinge; 2.6.3 -- Elliptical Notch Hinge; 2.6.4 -- Computerized Approximation of Concave Contours; 2.6.5 -- Instantaneous Center of Rotation; 2.6.6 -- Segmented Hinges; References; Chapter 3 -- AFM with Higher Mode Oscillations and Higher Sensitivity; 3.1 -- Effects of the resonance modes. Kinetostatic method; 3.1.1 -- Vibrating Beams; 3.1.1.1 -- Free End Cantilever.

3.1.1.2 -- Both Sides Clamped Beam3.1.1.3 -- Clamped-Supported Beam; 3.1.1.4 -- End Concentrated Mass; 3.2 -- Effective spring constants ratio; 3.3 -- Cantilever end inclination spring constants; 3.4 -- Quality factor influence; 3.4.1 -- AFM Tapping Mode Dynamics in Liquid; 3.5 -- End extended mass (V-shaped cantilever); 3.5.1 -- Outline of the Theory. Boundary Conditions; 3.5.2 -- Frequency Equation; 3.5.3 -- Ratios of Spring Constants; 3.5.3.1 -- Transformation of the Constituent Beam's Flexural Rigidity; 3.5.3.2 -- Spring Constant of Triangular (Trapezoid) Part.

3.5.4 -- Sensitivity to Additional Mass at Higher Modes3.6 -- Shift of resonant frequency; 3.7 -- Actuators and detectors; 3.7.1 -- Nanotubes (Hollow Cylinders); 3.7.2 -- Nonlocal and Asymmetric Elasticity; 3.7.2.1 -- Nonlocal Elasticity; 3.7.2.2 -- Asymmetric Elasticity; 3.8 -- Internal and external damping; 3.8.1 -- Ambient Influence and Protection; 3.8.1.1 -- Minimization of the Temperature Influence. Temperature Specified Parameters; 3.8.1.2 -- Heated Tip AFM Cantilevers; 3.8.1.3 -- Microcantilever Tip Thermal Oscillation; 3.8.2 -- Methods for the Design of Vibro-Isolation Means.

3.8.2.1 -- Acoustic Noise.