Cyclic-nucleotide phosphodiesterases in the central nervous system : from biology to drug discovery / [electronic resource]
by Brandon, Nicholas J [editor.]; West, Anthony R [editor.].
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BookSeries: Wiley series in drug discovery and development: Publisher: Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]Description: 1 online resource (xi, 386 pages) : illustrations (some color).ISBN: 9781118836323; 1118836324; 9781118836309; 1118836308; 9781118836538; 1118836537; 9781118836507; 1118836502; 047056668X; 9780470566688.Subject(s): Cyclic nucleotide phosphodiesterases | Central nervous system -- Physiology | Nucleotides, Cyclic | 3',5'-Cyclic-AMP Phosphodiesterases -- metabolism | 3',5'-Cyclic-AMP Phosphodiesterases -- therapeutic use | Central Nervous System -- physiology | Central Nervous System Diseases -- drug therapy | Drug Discovery | MEDICAL -- Physiology | SCIENCE -- Life Sciences -- Human Anatomy & Physiology | Central nervous system | Cyclic nucleotide phosphodiesterases | Electronic books | Electronic booksOnline resources: Wiley Online Library Includes bibliographical references.
Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P.P. Bollen, Kris Rutten, Olga A.H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin.
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