Neurodegeneration : the molecular pathology of dementia and movement disorders / [electronic resource]
by Dickson, Dennis [edt].
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BookPublisher: Chichester, West Sussex : Wiley-Blackwell, 2011Edition: 2nd ed.Description: 1 online resource (xvii, 477 pages) : illustrations (some color).ISBN: 9781444341256; 1444341251; 9781444341225; 1444341227.Subject(s): Nervous system -- Degeneration | Dementia -- Pathogenesis | Movement disorders | Neurodegenerative Diseases | Dementia -- pathology | Movement Disorders -- pathology | Dementia -- Pathogenesis | Dementia -- pathology | Movement Disorders -- pathology | Nervous system -- Degeneration | HEALTH & FITNESS -- Diseases -- Nervous System (incl. Brain) | MEDICAL -- Neurology | Electronic booksOnline resources: Wiley Online Library Includes bibliographical references and index.
Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders; Contents; List of Contributors; Preface; List of Abbreviations; Part 1: Introduction: Basic Mechanisms of Neurodegeneration; 1: Introduction to Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders; 2: Cell Death and Neurodegeneration; 3: Oxidative Stress and Balance in Neurodegenerative Diseases; 4: Protein Aggregation in Neurodegeneration; 5: Protein Degradation in Neurodegeneration: The Ubiquitin Pathway; 6: Genetics of Neurodegeneration; 7: Transgenic Animal Models of Proteinopathies.
Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology.℗¡ In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries.℗¡ Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells.
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