Includes bibliographical references and index.

Ageing of the human neuromuscular system : pathological aspects / W. King Engel and Valerie Askanas -- Aging of the human neuromuscular system : clinical considerations / W. King Engel and Valerie Askanas -- Aging of the human neuromuscular system : patient vignettes / W. King Engel, Shalini Mahajan, Valerie Askanas -- Mitochondrial changes in ageing with particular reference to muscle, and possible clinical consequences / Salvatore DiMauro, Eric Schon, Michio Hirano -- Protein degradation in ageing cells and mitochondria : relevance to the neuromuscular system / Jenny Ngo and Kelvin Davies -- Human muscle protein metabolism in relation to exercise and aging : potential therapeutic applications / Micah J. Drummond, Blake B. Rasmussen -- Pathogenesis of sporadic inclusion-body myositis / Valerie Askanas, W. King Engel, Anna Nogalska -- Inflammatory and autoimmune features of inclusion-body myositis / Marinos Dalakas -- Clinical symptoms, physical findings, and diagnostic investigations / Frank Mastaglia -- Pathologic diagnostic criteria of s-IBM and h-IBMS muscle biopsies / Valerie Askanas and W. King Engel -- Function and mutations of the GNE gene leading to DMRV/h-IBM, animal models, and potential treatments / May Malicdan, Satoru Noguchi, Ichizo Nishino -- Clinical and ethnic spectrum, laboratory data, and epidemiology of h-IBM due to GNE mutations / Zohar Argov, Ishizo Nishino, Ikiyo Nonaka -- Consequences of the h-IBM characteristic GNE mutations on muscle proteins in vivo and in vitro / Aldobrando Broccolini and Massimiliano Mirabella -- Function and structure of VCP mutations leading to h-IBM / Cezary Wojcik -- Clinical spectrum, including myopathy, Paget's disease, and fronto-temporal dementia : experimental models of VCP mutations, and potential treatments / Virginia Kimonis -- Animal models of h-IBM due to VCP mutation / Nisha M. Badders and Paul Taylor.

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