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Online resource; title from title details screen (ScienceDirect, viewed December 2, 2015).

Front Cover; Translating Regenerative Medicine to the Clinic; Copyright; Contents; Contributors; I -- Introduction; 1 -- Regenerative Medicine: The Hurdles and Hopes; Key Concepts; 1. INTRODUCTION; 2. ON THE ORIGINS OF REGENERATIVE MEDICINE; 3. FROM CELLS AND SCAFFOLDS TO TISSUES AND ORGANS; 4. BIOMATERIALS, TISSUE AND ORGAN BIOENGINEERING; 5. GENE THERAPY; 6. STEM CELL THERAPIES; 7. FUTURE DIRECTIONS; REFERENCES; II -- Biomaterials and Tissue/Organ Bioengineering; 2 -- Extracellular Matrix as an Inductive Scaffold for Functional Tissue Reconstruction; Key Concepts; 1. INTRODUCTION.

2. ECM AS A SCAFFOLD FOR REGENERATIVE MEDICINE2.1 The ECM as a Mechanical Substrate; 2.2 ECM Composition; 2.3 Dynamic Reciprocity; 2.4 Bioactive Degradation Products; 2.5 ECM as an Instructive Niche for Stem Cells; 3. DECELLULARIZATION AND FABRICATION METHODS; 4. TRANSLATIONAL APPLICATIONS OF ECM IN REGENERATIVE MEDICINE; 4.1 Esophageal Disease; 4.2 Volumetric Muscle Loss; 4.3 Temporomandibular Joint Meniscectomy; 5. MECHANISMS OF CONSTRUCTIVE REMODELING; 5.1 Mechanical Forces; 5.2 Modulation of the Host Response; 5.3 ECM Scaffold Degradation.

5.4 Undesirable Responses to ECM Scaffold Materials6. CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 3 -- Whole-Organ Bioengineering-Current Tales of Modern Alchemy; Key Concepts; 1. INTRODUCTION; 2. CURRENT STATUS OF ORGAN TRANSPLANTATION; 3. CURRENT STATUS ON ORGAN BIOENGINEERING; 3.1 Liver; 3.2 Intestine; 3.3 Kidney; 3.4 Heart; 3.5 Pancreas; 3.6 Lungs; 4. CURRENT APPLICATIONS FOR BIOENGINEERED ORGANS; 5. CURRENT LIMITATIONS; 5.1 Cell Sources and Expansion; 5.2 Assembly of Patent Vascular Networks; 5.3 Enabling Bioreactor Technologies; 5.4 Regulatory Challenges, Scaling Up, and Other Issues.

6. CONCLUSIONSREFERENCES; 4 -- Regenerative Implants for Cardiovascular Tissue Engineering; 1. INTRODUCTION; 1.1 The Path to a Regenerative Approach; 1.2 Brief Historical Overview of Vascular, Heart Valve, and Heart Implants; 1.2.1 Vascular Implants; 1.2.2 Heart Valve; 1.2.3 Whole Heart; 2. TYPES OF REGENERATIVE IMPLANTS-THE CONTINUITY BRIDGE; 2.1 Synthetic; 2.1.1 Degradable Synthetic Polymers; 2.1.2 Fabrication Methods; 2.2 Biologic; 2.2.1 ECM Gels; 2.2.2 Decellularized Scaffolds; 2.2.3 Hybrid; 3. FUNCTION OF IMPLANTS; 3.1 Implants as a Cell Delivery Vehicle Grown In Vitro.

3.1.1 Endothelial Progenitor Cells and MSCs3.1.2 Embryonic and Inducible Stem Cells; 3.1.3 BM Cells; 3.1.4 Cell Seeding Techniques; 3.2 Implants as an In Situ "Cell-Free" Tissue Forming Device; 3.3 Implants as a Drug Delivery Vehicle; 4. CLINICAL APPLICATIONS IN CARDIOVASCULAR REPAIR; 4.1 Vascular; 4.1.1 Vascular Patch; 4.1.2 Vascular Grafts; 4.2 Heart Valve; 4.3 Heart; 5. CONCLUSION; ACKNOWLEDGMENT; REFERENCES; 5 -- Tissue Engineering and Regenerative Medicine: Gastrointestinal Application; Key Concepts; 1. THE GASTROINTESTINAL TRACT: OVERVIEW; 2. NEURODEGENERATIVE DISEASES OF THE GI TRACT.

This review of current methodological tools and experimental approaches used by leading translational researchers, discusses the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle regeneration and regeneration of the bone and skin. Pedagogically, it concentrates on the latest knowledge, laboratory techniques and experimental approaches used by research leaders in the field. It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by emphasising recent innovations, critical barriers to progress, the new tools that are being used to overcome them and specific areas of research that require additional study to advance the field as a whole.

Includes bibliographical references and index.