000			03498cam a22003257a 4500
001			16967573
003			BD-DhUL
005			20150207165051.0
008			110919s2010 enka b 001 0 eng
010			_a 2011499097
015			_aGBB061209 _2bnb
016	7		_a015551602
020			_a9781849730136 (hbk.)
020			_a184973013X (hbk.)
040			_aUKM _cUKM _dYDXCP _dNUI _dUBY _dDLC _dBD-DhUL
050	0	0	_aQD79.C454 _bT48 2010
082	0	4	_a543.84 _222 _bTEH
100	1		_aTeutenberg, Thorsten.
245	1	0	_aHigh-temperature liquid chromatography : _ba user's guide for method development / _cThorsten Teutenberg.
260			_aCambridge : _bRSC Pub., _cc2010.
300			_ax, 210 p. : _bill. ; _c25 cm.
490	1		_aRSC chromatography monographs
504			_aIncludes bibliographical references and index.
505	0		_aA brief definition of high-temperature liquid chromatography -- System set-up for high-temperature liquid chromatography -- The heating system -- Mobile phase considerations -- Suitable stationary phases -- Method development using temperature as an active variable -- Analyte stability -- Special hyphenation techniques -- Critical outlook and future prospects.
520			_a"High-temperature liquid chromatography has attracted much interest in recent years but has not yet recognized its full potential in the chromatographic community. There is a widespread reluctance in industry to use temperature to speed up the separation process, influence the selectivity of a separation or implement novel detection techniques. However, the technology has now matured and could revolutionize chromatography as we see it today. Better equipment, such as heating systems able to generate faster heating rates, is becoming more readily available. Also, columns based on silica gel, which can withstand higher temperatures for an extended period, are now being introduced. Nevertheless, further technological and methodical efforts are needed to establish the method in a regulated environment like the pharmaceutical industry. This is the only text to cover all the practical aspects, as well as the underlying theoretical principles, of setting up an HPLC system for high temperature operation. It is not intended solely for academics but will also benefit the researcher interested in more practical considerations. The author is a recognized expert and has conducted several studies with partners from industry to validate the method. Many real examples from these studies have been included in the book. The aim is to support practitioners in the creation of their own protocols without the need to rely solely on trial and error. The book starts with a brief definition of high temperature liquid chromatography before going on to cover: system set up; the heating system; mobile phase considerations; suitable stationary phases; method development using temperature programming; analyte stability, and special hyphenation techniques using superheated water as a mobile phase. In each chapter, experimental data is used to illustrate the main statements and the advantages over conventional HPLC are evaluated. The book concludes with a critical outlook on further developments and applications underlining the necessary advances needed to make high temperature HPLC more robust."--Back cover.
650		0	_aHigh performance liquid chromatography.
650		0	_aHigh temperature chemistry.
830		0	_aRSC chromatography monographs.
942			_2ddc _cBK
999			_c15726 _d15726