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020			_a9781849731973
035			_a(WaSeSS)ssj0000578410
037			_b00154291
040			_aBIP US _dWaSeSS _dWaSeSS _bBD-DhUL _cWaSeSS
050		4	_aQD502
082	0	0	_a547.215 _222 _bPEC
100	1		_aPellissier, Hélène _eAuthor
245	1	0	_aChirality from Dynamic Kinetic Resolution / _c Hélène Pellissier.
260			_aCambridge : _bRSC, _c 2011.
300			_axviii, 299 p. : _bill. ; _c24 cm.
365			_aUS$ _b148.50
504			_aIncludes bibliographical references and index.
520	8		_aAnnotation _bThe last 15 years have witnessed significant developments in the efficiency and scope of the application of DKR. These now offer a serious alternative to conventional methods for asymmetric synthesis. Indeed, impressive examples using new enzymes and major progress in the DKR of racemates have taken place over the past few years. The powerful combination of enzymes and metals has also been the subject of spectacular development. In addition, a new type of DKR, involving organocatalysts, has recently appeared. Although asymmetric catalysis has undergone development during the last two decades, the most common industrial process used to obtain enantiomerically pure compounds is still via resolution of racemic mixtures. This is despite the major disadvantage that only a maximum of 50% product yield can be obtained. It is not surprising that DKR, which solves the problem of the limitation in yield, has attracted an increasing amount of interest from both the industrial and the academic perspective. This book provides an up-date on the principle methods employed to obtain dynamic kinetic resolution (DKR) by either enzymatic or non-enzymatic methods. It also illustrates the diversity of useful chiral products that can be obtained through this powerful concept. Divided into three sections, the book deals successively with non-enzymatic methods, enzymatic methods, and the use of transition metals and enzymes in tandem.
650		0	_aChirality.
650		0	_aChemical kinetics.
942			_2ddc _cBK
999			_c16644 _d16644