000			04887cam a2200661Ii 4500
001			ocn729726279
003			OCoLC
005			20171119083014.0
006			m o d
007			cr cn|||||||||
008			110609s2011 gw a ob 001 0 eng d
020			_a9783527635955 _q(electronic bk.)
020			_a3527635955 _q(electronic bk.)
020			_a9783527635979 _q(electronic bk.)
020			_a3527635971 _q(electronic bk.)
020			_a1283140918
020			_a9781283140911
020			_z9783527326969 _q(hbk.)
020			_z3527326960 _q(hbk.)
020			_z9783527635962
020			_z3527635963
020			_z9783527635986
020			_z352763598X
024	8		_a9786613140913
029	1		_aAU@ _b000047551108
029	1		_aNZ1 _b14693860
029	1		_aNZ1 _b15915098
035			_a(OCoLC)729726279 _z(OCoLC)740225701 _z(OCoLC)741454003 _z(OCoLC)778454561 _z(OCoLC)781264224 _z(OCoLC)785512762 _z(OCoLC)816845214
037			_a10.1002/9783527635955 _bWiley InterScience _nhttp://www3.interscience.wiley.com
040			_aDG1 _beng _erda _epn _cDG1 _dYDXCP _dCDX _dOCLCQ _dE7B _dN$T _dSCB _dOCLCQ _dMHW _dOTZ _dIDEBK _dOCLCQ _dNLGGC _dOCLCQ _dCOO _dOCLCQ _dTMC _dD6H
049			_aMAIN
050		4	_aRS431.A66 _bA68 2011
060		4	_aQV268.5
072		7	_aMED _x071000 _2bisacsh
082	0	4	_a615.7924 _222
245	0	0	_aAntiviral drug strategies / _cedited by Erik De Clercq. _h[electronic resource]
264		1	_aWeinheim : _bWiley-VCH ; _aChichester : _bJohn Wiley [distributor], _c2011.
300			_a1 online resource (xx, 406 pages) : _billustrations (some color).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aMethods and principles in medicinal chemistry ; _vv. 50
504			_aIncludes bibliographical references and index.
505	0	0	_tOutlook of the antiviral drug era, now more than 50 years after description of the first antiviral drug / _rErik De Clercq -- _tInhibition of HIV entry / _rJosé A. Esté -- _tTargeting integration beyond strand transfer: development of second-generation HIV integrase inhibitors / _rArnout R.D. Voet, _rMarc De Maeyer, _rFrauke Christ, _rZeger Debyser -- _tFrom saquinavir to darunavir: the impact of 10 years of medicinal chemistry on a lethal disease / _rMarie-Pierre de Béthune, _rAnik Peeters, _rPiet Wigerinck -- _tAcyclic and cyclic nucleoside phosphonates / _rRichard L. Mackman, _rTomas Cihlar -- _tHelicase-primase inhibitors: a new approach to combat herpes simplex virus and varicella zoster virus / _rSubhajit Biswas, _rHugh J. Field -- _tCyclophilin inhibitors / _rGrégoire Vuagniaux, _rArnaud Hamel, _rRafael Crabbé, _rHervé C. Porchet, _rJean-Maurice Dumont -- _tAlkoxyalkyl ester prodrugs of antiviral nucleoside phosphates and phosphonates / _rJames R. Beadle, _rKarl Y. Hostetler -- _tMaribavir: a novel benzimidazole ribonucleoside for the prevention and treatment of cytomegalovirus diseases / _rKaren K. Biron -- _tAnti-HCMV compounds / _rGraciela Andrei, _rRobert Snoeck -- _tLethal mutagenesis as an unconventional approach to combat HIV / _rPinar Iyidogan, _rKaren S. Anderson -- _tRecent progress in the development of HCV protease inhibitors / _rNagraj Mani, _rBhisetti G. Rao, _rTara L. Kieffer, _rAnn D. Kwong -- _tAntiviral RNAi: how to silence viruses / _rKarin J. von Eije, _rBen Berkhout -- _tNeuraminidase inhibitors as anti-influenza agents / _rWillard Lew, _rMichael Z. Wang, _rXiaowu Chen, _rJames F. Rooney, _rChoung Kim -- _tFrom TIBO to rilpivirine: the chronicle of the discovery of the ideal nonnucleoside reverse transcriptase inhibitor / _rErik De Clercq.
520			_aBy focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de.
588	0		_aPrint version record.
650		0	_aAntiviral agents _xDevelopment.
650		4	_aAntiviral agents _xDevelopment.
650		7	_aMEDICAL _xPharmacology. _2bisacsh
650		2	_aAntiviral Agents.
650		2	_aDrug Discovery.
655		4	_aElectronic books.
700	1		_aDe Clercq, Erik.
776	0	8	_iPrint version: _tAntiviral drug strategies. _dWeinheim : Wiley-VCH ; Chichester : John Wiley [distributor], 2011 _z9783527326969 _w(OCoLC)664325845
830		0	_aMethods and principles in medicinal chemistry ; _vv. 50.
856	4	0	_uhttp://onlinelibrary.wiley.com/book/10.1002/9783527635955 _zWiley Online Library
942			_2ddc _cBK
999			_c205122 _d205122