000			06564cam a2200841Ka 4500
001			ocn746324268
003			OCoLC
005			20171116113103.0
006			m o d
007			cr cn|||||||||
008			110811s2011 nju ob 001 0 eng d
010			_z 2011008300
020			_a9781118092804 _q(electronic bk.)
020			_a1118092805 _q(electronic bk.)
020			_a9781118092835 _q(electronic bk.)
020			_a111809283X _q(electronic bk.)
020			_a1283239906
020			_a9781283239905
020			_z9780470596685
020			_z0470596686
020			_z9781118092811
024	8		_a9786613239907
029	1		_aAU@ _b000047980772
029	1		_aAU@ _b000053283782
029	1		_aDKDLA _b820120-katalog:000582692
029	1		_aNZ1 _b14691830
029	1		_aDEBBG _bBV043393375
035			_a(OCoLC)746324268 _z(OCoLC)748534091 _z(OCoLC)751970372 _z(OCoLC)757395717 _z(OCoLC)759006616 _z(OCoLC)816859643 _z(OCoLC)961631470 _z(OCoLC)962609688 _z(OCoLC)966196074
037			_a10.1002/9781118092804 _bWiley InterScience _nhttp://www3.interscience.wiley.com
040			_aDG1 _beng _epn _cDG1 _dIDEBK _dOCLCQ _dYDXCP _dN$T _dCDX _dE7B _dOCLCQ _dOCLCF _dOCLCA _dUKDOC _dOCLCQ _dNLGGC _dEBLCP _dOCLCQ _dDEBBG _dD6H _dAZK _dLOA _dOCLCO _dOCLCA
049			_aMAIN
050		4	_aRS400 _b.M438 2011
060		4	_aQV 185
072		7	_aMED _x023000 _2bisacsh
072		7	_aMED _x058170 _2bisacsh
072		7	_aMED _x071000 _2bisacsh
072		7	_aMED _x072000 _2bisacsh
072		7	_aPN _2bicssc
082	0	4	_a615/.19 _222
245	0	0	_aMedicinal chemistry of nucleic acids / _cedited by Li He Zhang, Zhen Xi, Jyoti Chattopadhyaya. _h[electronic resource]
260			_aHoboken, N.J. : _bJohn Wiley & Sons, _c©2011.
300			_a1 online resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aWiley series in drug discovery and development
504			_aIncludes bibliographical references and index.
505	0		_aFrontmatter -- Color Plates -- Recent Advances in Carbocyclic Nucleosides: Synthesis and Biological Activity / Jianing Wang, Ravindra K Rawal, Chung K Chu -- Structures and Functions of Nucleic Acids Modified With S, Se, and Te and Complexed with Small Molecules / Wen Zhang, Jia Sheng, Zhen Huang -- Unraveling of the NAD Cyclizing and Calcium Signaling Functions of Human CD38 / Hon Cheung Lee -- DNA and RNA Binding Small Molecules / Shibo Li, Zhen Xi -- G-Quadruplex DNA and its Ligands in Anticancer Therapy / Zhi-Shu Huang, Jia-Heng Tan, Tian-Miao Ou, Ding Li, Lian-Quan Gu -- Molecular Modeling in Nucleic Acid-Targeted Drug Design / Lidan Sun, Hongwei Jin, Liangren Zhang, Lihe Zhang -- Structure of 10₆23 DNAzyme in Complex with the Target RNA --A Progress Report on the Mechanism of RNA Cleavage by DNA Enzyme / Oleksandr Plashkevych, Jyoti Chattopadhyaya -- Labeling Oligonucleotides toward the Biomedical Probe / Il Joon Lee, Byeang Hyean Kim -- Locked Nucleic Acid Oligonucleotides toward Clinical Applications / Rakesh N Veedu, Jesper Wengel -- The Pharmacokinetics Research of Nucleic Acid Drugs / Shengqi Wang, Dandan Lu, Qingqing Wang, Haifeng Song, Chan Gao, Caihong Liu, Ying Wang -- Inducible RNAi and Drug Target Validation / Wei Xiong, Jing Zhao, Yufan Zhang, Jinxi Wang, Yong-Xiang Zheng, Qiu-Chen He, Li-He Zhang, De-Min Zhou -- siRNA: The Specificity and off-Target Effects / Quan Du, Huang Huang, Zicai Liang -- Index -- Wiley Series in Drug Discovery and Development.
505	0		_aRecent advances in carbocyclic nucleosides : synthesis and biological activity / Jianing Wang, Ravindra K. Rawal, and Chung K. Chu -- Structures and functions of nucleic acids modified with S, Se, and Teand complexed with small molecules / Wen Zhang, Jia Sheng, and Zhen Huang -- Unraveling of the NAD cyclizing and calcium signaling functions of human CD38 / Hon Cheung Lee -- DNA and RNA binding small molecules / Shibo Li and Zhen Xi -- G-quadruplex DNA and its ligands in anticancer therapy / Zhi-shu Huang [and others] -- Molecular modeling in nucleic acid targeted drug design / Lidan Sun [and others] -- Structure of 10-23 DNAzyme in complex with the target RNA in silico : a progress report on the mechanism of RNA cleavage by DNA enzyme / Oleksandr Plashkevych and Jyoti Chattopadhyaya -- Labeling oligonucleotides towards the biomedical probe / Il Joon Lee and Byeang Hyean Kim -- Locked nucleic acid oligonucleotides towards clinical application / Rakesh N. Veedu and Jesper Wengel -- The pharmacokinetics researches of nucleic acid drugs / Shengqi Wang -- Inducible RNAi and drug target validation / Wei Xiong [and others] -- SiRNA : the specificity and off-target effects -- Quan Du, Huang Huang, Zicai Liang.
520			_aCovering all areas of the medicinal chemistry and therapeutic applications of nucleic acids, this book provides up-to-date coverage of the broad area of nucleic acid chemistry and biology. The book lays out the basic principles of medicinal chemistry of nucleic acids before focusing on the development and application of modified nucleosides and nucleotides in medicinal chemistry. Cutting-edge subjects for drug discovery like antisense, RNAi, and siRNA are also discussed, and help the target audience of chemists, pharmaceutical researchers, and academics understand the use of nucleic acid drugs to treat diseases.
588	0		_aPrint version record.
650		0	_aPharmaceutical chemistry.
650		0	_aNucleic acids _xTherapeutic use.
650		7	_aMEDICAL _xDrug Guides. _2bisacsh
650		7	_aMEDICAL _xNursing _xPharmacology. _2bisacsh
650		7	_aMEDICAL _xPharmacology. _2bisacsh
650		7	_aMEDICAL _xPharmacy. _2bisacsh
650		7	_aNucleic acids _xTherapeutic use. _2fast _0(OCoLC)fst01041085
650		7	_aPharmaceutical chemistry. _2fast _0(OCoLC)fst01060115
650		2	_aNucleic Acids _xpharmacology.
650		2	_aNucleic Acids _xtherapeutic use.
655		4	_aElectronic books.
655		4	_aElectronic resource.
655		7	_aElectronic books. _2local
700	1		_aZhang, Li He.
700	1		_aXi, Zhen.
700	1		_aChattopadhyaya, Jyoti.
710	2		_aWiley InterScience (Online service)
776	0	8	_iPrint version: _tMedicinal chemistry of nucleic acids. _dHoboken, N.J. : John Wiley & Sons, Inc., ©2011 _z9780470596685 _w(DLC) 2011008300 _w(OCoLC)705260904
830		0	_aWiley series in drug discovery and development.
856	4	0	_uhttp://onlinelibrary.wiley.com/book/10.1002/9781118092804 _zWiley Online Library
942			_2ddc _cBK
999			_c205198 _d205198