000			03862cam a2200589Mi 4500
001			ocn768082726
003			OCoLC
005			20171116085825.0
006			m o d
007			cr |n|---|||||
008			111212s2012 enk ob 000 0 eng d
020			_a9781118150573 _q(electronic bk.)
020			_a1118150570 _q(electronic bk.)
020			_a9781118150542
020			_a1118150546
020			_z9780470497180 _q(cloth)
029	1		_aAU@ _b000049117727
029	1		_aGBVCP _b79003493X
029	1		_aNLGGC _b38961887X
029	1		_aNZ1 _b15900544
029	1		_aDEBBG _bBV043393821
035			_a(OCoLC)768082726
040			_aEBLCP _beng _epn _cEBLCP _dOCLCQ _dDG1 _dOCLCQ _dCOO _dOCLCQ _dDEBBG
049			_aMAIN
050		4	_aQV25 _b.A53 2012
082	0	4	_a615.19
245	0	0	_aAnalysis of aggregates and particles in protein pharmaceuticals / _cedited by Hanns-Christian Mahler, Wim Jiskoot. _h[electronic resource]
260			_aChicester : _bJohn Wiley & Sons, _c2012.
300			_a1 online resource (474 pages)
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
504			_aIncludes bibliographical references.
505	0		_aANALYSIS OF AGGREGATES AND PARTICLES IN PROTEIN PHARMACEUTICALS; CONTENTS; Contributors; Preface; Glossary; 1 The Critical Need for Robust Assays for Quantitation and Characterization of Aggregates of Therapeutic Proteins; I METHODS USED FOR DETECTING, QUANTIFYING, AND SIZING OF PROTEIN AGGREGATES AND PARTICLES; 2 Separation-Based Analytical Methods for Measuring Protein Aggregation; 3 Laser Light Scattering-Based Techniques Used for the Characterization of Protein Therapeutics; 4 Online Detection Methods and Emerging Techniques for Soluble Aggregates in Protein Pharmaceuticals.
505	8		_a5 Analytical Methods to Measure Subvisible Particulates6 Detection of Visible Particles in Parenteral Products; 7 Characterization of Aggregates and Particles Using Emerging Techniques; II METHODS USED TO CHARACTERIZE PROTEIN AGGREGATES AND PARTICLES; 8 Ultraviolet Absorption Spectroscopy; 9 Fluorescence Spectroscopy to Characterize Protein Aggregates and Particles; 10 Infrared Spectroscopy to Characterize Protein Aggregates; 11 Raman Microscopy for Characterization of Particles; 12 Microscopic Methods for Particle Characterization in Protein Pharmaceuticals.
505	8		_aIII INTEGRATED APPROACHES TO PROTEIN AGGREGATION AND PARTICLES13 Comparison of Methods for Soluble Aggregate Detection and Size Characterization; 14 Protein Purification and Its Relation to Protein Aggregation and Particles; 15 Formulation Development and Its Relation to Protein Aggregation and Particles; Index.
520			_aThis book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.
588	0		_aPrint version record.
650		0	_aPharmaceutical chemistry.
650		0	_aProtein drugs _xAnalysis.
650		4	_aChemistry Techniques, Analytical _xmethods.
650		4	_aPharmaceutical Preparations _xanalysis.
650		4	_aProteins _xpharmacokinetics.
650		4	_aPharmacy.
650		4	_aMedicine.
655		4	_aElectronic books.
700	1		_aMahler, Hanns-Christian.
700	1		_aJiskoot, Wim.
776	0	8	_iPrint version: _aMahler, Hanns-Christian. _tAnalysis of Aggregates and Particles in Protein Pharmaceuticals. _dChicester : John Wiley & Sons, ©2012 _z9780470497180
856	4	0	_uhttp://onlinelibrary.wiley.com/book/10.1002/9781118150573 _zWiley Online Library
942			_2ddc _cBK
999			_c205429 _d205429