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001 ocn808867147
003 OCoLC
005 20171114084431.0
006 m o d
007 cr |n|||||||||
008 120229s2012 nju ob 001 0 eng d
010 _z 2012002908
020 _a9781118351918
_q(electronic bk.)
020 _a1118351916
_q(electronic bk.)
020 _a9781118351888
_q(electronic bk.)
020 _a1118351886
_q(electronic bk.)
020 _a9781118351901
_q(electronic bk.)
020 _a1118351908
_q(electronic bk.)
020 _z9780470577547
_q(Cloth)
020 _z0470577541
_q(Cloth)
024 8 _a9786613888525
028 0 1 _aEB00063407
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029 1 _aDKDLA
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029 1 _aNZ1
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029 1 _aDEBBG
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035 _a(OCoLC)808867147
_z(OCoLC)808609679
_z(OCoLC)809539042
_z(OCoLC)864910874
_z(OCoLC)961633114
_z(OCoLC)962651029
_z(OCoLC)966109639
037 _a388852
_bMIL
040 _aCDX
_beng
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049 _aMAIN
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060 4 _aWA 671
072 7 _aMED
_x096000
_2bisacsh
082 0 4 _a615.9/5137
_223
100 1 _aRadi, Zaher A.
245 1 0 _aComparative pathophysiology and toxicology of cyclooxygenases /
_cZaher A. Radi.
_h[electronic resource]
260 _aHoboken, N.J. :
_bWiley,
_c©2012.
300 _a1 online resource
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _adata file
_2rda
380 _aBibliography
504 _aIncludes bibliographical references and index.
520 _aThe first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks. Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks. Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover: The pathophysiology of COX inhibition on bone, tendon, and ligament healing, COX inhibitors and renal system pathophysiology and mechanisms of toxicity, The pathophysiologic role of COX inhibition in the ocular system, COX inhibition and the respiratory and cardiovascular systems. The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs.
588 0 _aPrint version record.
650 0 _aCyclooxygenases
_xPathophysiology.
650 0 _aCyclooxygenases
_xToxicology.
650 7 _aMEDICAL
_xToxicology.
_2bisacsh
650 7 _aScience.
_2fast
_0(OCoLC)fst01108176
655 4 _aElectronic books.
655 7 _aElectronic books.
_2local
776 0 8 _iPrint version:
_z9786613888525
_w(DLC) 2012002908
856 4 0 _uhttp://onlinelibrary.wiley.com/book/10.1002/9781118351918
_zWiley Online Library
942 _2ddc
_cBK
999 _c206137
_d206137