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003 OCoLC
005 20171114083050.0
006 m o d
007 cr |||||||||||
008 120907t20122012njua ob 001 0 eng
010 _z 2012012322
020 _a9781118437674
_q(electronic bk.)
020 _a1118437675
_q(electronic bk.)
020 _a9781118435762
_q(electronic bk.)
020 _a1118435761
_q(electronic bk.)
020 _a9781118434505
_q(electronic bk.)
020 _a1118434501
_q(electronic bk.)
020 _z9781118101186
020 _z1118101189
020 _z9781283576055
020 _z1283576058
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035 _a(OCoLC)809370453
_z(OCoLC)808771990
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_z(OCoLC)841331222
_z(OCoLC)961537416
_z(OCoLC)962595044
_z(OCoLC)966148373
037 _aCL0500000213
_bSafari Books Online
037 _aFB5E82B8-484A-4B92-BA65-C660A94D88E7
_bOverDrive, Inc.
_nhttp://www.overdrive.com
040 _aDG1
_beng
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049 _aMAIN
050 4 _aQP514.2
060 4 _aQV 745
072 7 _aSCI
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082 0 4 _a572
_223
245 0 0 _aChemical biology : approaches to drug discovery and development to targeting disease /
_cedited by Natanya Civjan.
_h[electronic resource]
264 1 _aHoboken, N.J. :
_bWiley, a John Wiley & Sons, Inc., Publication,
_c[2012]
264 4 _c©2013
300 _a1 online resource (525 pages) :
_billustrations
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _adata file
_2rda
380 _aBibliography
504 _aIncludes bibliographical references and index.
505 0 _aPart I: Drug discovery and development. The role of chemical biology in drug discovery -- Computational approaches to drug discovery and development -- Design and selection of small molecule inhibitors -- Lead optimization in drug discovery -- Pharmacokinetics of drug candidates -- ADME properties of drugs -- Drug transport in living systems -- Blood-brain barrier: considerations in drug development and delivery -- Pharmacokinetic considerations: methods and systems of controlled drug delivery -- Pharmaceuticals: natural products and natural product models -- Part II: Chemical biology to understand and target disease. The role of chemical biology in understanding and treating disease: are small molecule "correctors" the way of the future? -- Anxiety disorders -- Chronic obstructive pulmonary disease (COPD) -- Depression -- Osteoarthritis -- Human immunodeficiency virus (HIV) -- Allergy and asthma -- Schizophrenia -- Protein misfolding and disease -- Protein trafficking diseases -- Metabolic diseases -- Mitochondrial medicine -- Lysosomal disorders.
520 _a"Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease"--Provided by publisher.
588 0 _aOnline resource; title from electronic title page (ebrary, viewed on February 24, 2015).
650 0 _aBiochemistry.
650 1 2 _aDrug Discovery.
650 2 2 _aDrug Delivery Systems.
650 4 _aBiochemistry.
650 7 _aSCIENCE
_xLife Sciences
_xBiochemistry.
_2bisacsh
650 7 _aBiochemistry.
_2fast
_0(OCoLC)fst00831961
650 7 _aBiochemistry.
_2local
655 4 _aElectronic books.
655 7 _aElectronic books.
_2local
700 1 _aCivjan, Natanya,
_eeditor.
776 0 8 _iPrint version:
_tChemical biology.
_dHoboken, N.J. : Wiley, 2012
_z9781118101186
_w(DLC) 2012012322
_w(OCoLC)749857596
856 4 0 _uhttp://onlinelibrary.wiley.com/book/10.1002/9781118435762
_zWiley Online Library
942 _2ddc
_cBK
999 _c206148
_d206148