000			04742cam a2200769Ii 4500
001			ocn809370453
003			OCoLC
005			20171114083050.0
006			m o d
007			cr |||||||||||
008			120907t20122012njua ob 001 0 eng
010			_z 2012012322
020			_a9781118437674 _q(electronic bk.)
020			_a1118437675 _q(electronic bk.)
020			_a9781118435762 _q(electronic bk.)
020			_a1118435761 _q(electronic bk.)
020			_a9781118434505 _q(electronic bk.)
020			_a1118434501 _q(electronic bk.)
020			_z9781118101186
020			_z1118101189
020			_z9781283576055
020			_z1283576058
029	1		_aAU@ _b000050060747
029	1		_aAU@ _b000051432790
029	1		_aDEBBG _bBV041121688
029	1		_aDEBBG _bBV041829088
029	1		_aDEBSZ _b396766102
029	1		_aDEBSZ _b431131015
029	1		_aDKDLA _b820120-katalog:000600184
029	1		_aNZ1 _b14976643
029	1		_aAU@ _b000059228019
035			_a(OCoLC)809370453 _z(OCoLC)808771990 _z(OCoLC)811488646 _z(OCoLC)841331222 _z(OCoLC)961537416 _z(OCoLC)962595044 _z(OCoLC)966148373
037			_aCL0500000213 _bSafari Books Online
037			_aFB5E82B8-484A-4B92-BA65-C660A94D88E7 _bOverDrive, Inc. _nhttp://www.overdrive.com
040			_aDG1 _beng _erda _epn _cDG1 _dOCLCQ _dN$T _dYDXCP _dE7B _dOCLCQ _dCDX _dOCLCQ _dCCO _dMHW _dUMI _dOCLCO _dCOO _dDEBSZ _dTEFOD _dOCLCQ _dOCLCF _dOCLCQ _dMMU _dTEFOD _dEBLCP _dOCLCQ _dAZK _dDG1 _dOCLCO _dLOA _dOCLCA
049			_aMAIN
050		4	_aQP514.2
060		4	_aQV 745
072		7	_aSCI _x007000 _2bisacsh
082	0	4	_a572 _223
245	0	0	_aChemical biology : approaches to drug discovery and development to targeting disease / _cedited by Natanya Civjan. _h[electronic resource]
264		1	_aHoboken, N.J. : _bWiley, a John Wiley & Sons, Inc., Publication, _c[2012]
264		4	_c©2013
300			_a1 online resource (525 pages) : _billustrations
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_adata file _2rda
380			_aBibliography
504			_aIncludes bibliographical references and index.
505	0		_aPart I: Drug discovery and development. The role of chemical biology in drug discovery -- Computational approaches to drug discovery and development -- Design and selection of small molecule inhibitors -- Lead optimization in drug discovery -- Pharmacokinetics of drug candidates -- ADME properties of drugs -- Drug transport in living systems -- Blood-brain barrier: considerations in drug development and delivery -- Pharmacokinetic considerations: methods and systems of controlled drug delivery -- Pharmaceuticals: natural products and natural product models -- Part II: Chemical biology to understand and target disease. The role of chemical biology in understanding and treating disease: are small molecule "correctors" the way of the future? -- Anxiety disorders -- Chronic obstructive pulmonary disease (COPD) -- Depression -- Osteoarthritis -- Human immunodeficiency virus (HIV) -- Allergy and asthma -- Schizophrenia -- Protein misfolding and disease -- Protein trafficking diseases -- Metabolic diseases -- Mitochondrial medicine -- Lysosomal disorders.
520			_a"Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease"--Provided by publisher.
588	0		_aOnline resource; title from electronic title page (ebrary, viewed on February 24, 2015).
650		0	_aBiochemistry.
650	1	2	_aDrug Discovery.
650	2	2	_aDrug Delivery Systems.
650		4	_aBiochemistry.
650		7	_aSCIENCE _xLife Sciences _xBiochemistry. _2bisacsh
650		7	_aBiochemistry. _2fast _0(OCoLC)fst00831961
650		7	_aBiochemistry. _2local
655		4	_aElectronic books.
655		7	_aElectronic books. _2local
700	1		_aCivjan, Natanya, _eeditor.
776	0	8	_iPrint version: _tChemical biology. _dHoboken, N.J. : Wiley, 2012 _z9781118101186 _w(DLC) 2012012322 _w(OCoLC)749857596
856	4	0	_uhttp://onlinelibrary.wiley.com/book/10.1002/9781118435762 _zWiley Online Library
942			_2ddc _cBK
999			_c206148 _d206148