000 | 05462cam a2200853Ia 4500 | ||
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001 | ocn823389939 | ||
003 | OCoLC | ||
005 | 20171112123948.0 | ||
006 | m o d | ||
007 | cr |n||||||||| | ||
008 | 121227s2013 njuaf ob 001 0 eng d | ||
020 | _a9781118516157 | ||
020 | _a111851615X | ||
020 | _a9781118516126 | ||
020 | _a1118516125 | ||
020 | _a9781283917520 | ||
020 | _a1283917521 | ||
020 | _z9780470942383 | ||
020 | _z047094238X | ||
029 | 1 |
_aAU@ _b000050590993 |
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029 | 1 |
_aDEBBG _bBV041049285 |
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029 | 1 |
_aDEBBG _bBV041829130 |
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029 | 1 |
_aDEBBG _bBV041908799 |
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029 | 1 |
_aNZ1 _b15194662 |
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029 | 1 |
_aNZ1 _b15340440 |
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035 |
_a(OCoLC)823389939 _z(OCoLC)836200869 _z(OCoLC)860794225 |
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037 |
_a10.1002/9781118516157 _bWiley InterScience _nhttp://www3.interscience.wiley.com |
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040 |
_aMHW _beng _epn _cMHW _dOCLCO _dEBLCP _dDG1 _dN$T _dYDXCP _dMYG _dCDX _dIDEBK _dIUL _dE7B _dNOC _dOCLCO _dOCLCF _dOCLCQ _dRECBK _dU3G _dUKDOC _dDEBBG _dCOO _dOCLCQ |
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049 | _aMAIN | ||
050 | 4 |
_aRS189.5.S65 _bM37 2013eb |
|
060 | 4 | _aQV 744 | |
072 | 7 |
_aMED _x023000 _2bisacsh |
|
072 | 7 |
_aMED _x058170 _2bisacsh |
|
072 | 7 |
_aMED _x071000 _2bisacsh |
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072 | 7 |
_aMED _x072000 _2bisacsh |
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082 | 0 | 4 |
_a615.1 _a615.19 |
245 | 0 | 0 |
_aMass spectrometry for drug discovery and drug development / _cedited by Walter A. Korfmacher. _h[electronic resource] |
260 |
_aHoboken, N.J. : _bWiley, _c2013. |
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300 |
_a1 online resource (xii, 461 pages, [16] pages of plates)) : _billustrations (some color). |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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490 | 1 | _aWiley series on mass spectrometry | |
504 | _aIncludes bibliographical references and index. | ||
505 | 0 | _a1. Overview of the various types of mass spectrometers that are used in drug discovery and drug development / Gerard Hopfgartner -- 2. Utility of high resolution mass spectrometry for new drug discovery applications / William Bart Emary and Nanyan Rena Zhang -- 3. Quantitative mass spectrometry considerations in a regulated environment / Mohammed Jemal and Yuan-Qing Xia -- 4. Mass spectrometry for quantitative in vitro ADME assays / Jun Zhang and Wilson Z. Shou -- 5. Metabolite identification using mass spectrometry in drug development / Natalia Penner, Joanna Zgoda-Pols, and Chandra Prakash -- 6. MS analysis of biological drugs, proteins, and peptides / Yi Du, John Mehl, and Pavlo Pristatsky -- 7. Characterization of impurities and degradation products in small molecule pharmaceuticals and biologics / Hui Wei, Guodong Chen and Adrienne A. Tymiak -- 8. Liquid extraction surface analysis (LESA) : a new mass spectrometry-based technique for ambient surface profiling / Dan Eikel and Jack Henion -- 9. MS applications in support of medicinal chemistry sciences / Maarten Honing, Benno Ingelse, and Birendraÿ N. Pramanik -- 10. Imaging mass spectrometry of proteins and peptides / Michelle L. Reyzer and Richard M. Caprioli -- 11. Imaging mass spectrometry for drugs and metabolites / Stacey R. Oppenheimer -- 12. Screening reactive metabolites : role of liquid chromatography-high resolution mass spectrometry in combination with 'intelligent' data mining tools / Shuguang Ma and Swapan K. Chowdhury -- 13. Mass spectrometry of siRNA / Mark Cancilla and Mike Flanagan -- 14. Mass spectrometry for metabolomics / Petia Shipkova and Michael D. Reily -- 15. Quantitative analysis of peptides with mass spectrometry : selected reaction monitoring or high resolution full scan? / Lieve Dillen and Filip Cuyckens. | |
520 | _aThis book presents a summary of the ways mass spectrometry is used in various stages of drug discovery and development including early support of medicinal chemistry, drug metabolism studies, distribution, degradation, and various development assays. The book includes a balance of basic and advanced information. Specific chapters relate to various stages in the process (e.g., discovery) as well as chapters on topics of current interest (lipidomics and SiRNA) are covered. | ||
588 | 0 | _aPrint version record. | |
650 | 0 |
_aDrugs _xAnalysis. |
|
650 | 0 | _aDrug development. | |
650 | 0 | _aMass spectrometry. | |
650 | 1 | 2 | _aDrug Discovery. |
650 | 1 | 2 |
_aMass Spectrometry _xmethods. |
650 | 2 | 2 |
_aPeptides _xanalysis. |
650 | 2 | 2 |
_aPharmaceutical Preparations _xanalysis. |
650 | 2 | 2 |
_aProteins _xanalysis. |
650 | 4 | _aDrug discovery. | |
650 | 4 |
_aMass spectrometry _xMethods. |
|
650 | 4 |
_aPeptides _xAnalysis. |
|
650 | 4 |
_aPharmaceutical preparations _xAnalysis. |
|
650 | 4 |
_aProteins _xAnalysis. |
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650 | 7 |
_aMEDICAL _xDrug Guides. _2bisacsh |
|
650 | 7 |
_aMEDICAL _xNursing _xPharmacology. _2bisacsh |
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650 | 7 |
_aMEDICAL _xPharmacology. _2bisacsh |
|
650 | 7 |
_aMEDICAL _xPharmacy. _2bisacsh |
|
650 | 7 |
_aDrug development. _2fast _0(OCoLC)fst00898670 |
|
650 | 7 |
_aDrugs _xAnalysis. _2fast _0(OCoLC)fst00898769 |
|
650 | 7 |
_aMass spectrometry. _2fast _0(OCoLC)fst01011435 |
|
655 | 4 | _aElectronic books. | |
700 | 1 | _aKorfmacher, Walter A. | |
776 | 0 | 8 |
_iPrint version: _tMass spectrometry for drug discovery and drug development. _dHoboken, N.J. : John Wiley & Sons, ©2013 _z9780470942383 _w(DLC) 2012031775 _w(OCoLC)806291832 |
830 | 0 | _aWiley-Interscience series on mass spectrometry. | |
856 | 4 | 0 |
_uhttp://onlinelibrary.wiley.com/book/10.1002/9781118516157 _zWiley Online Library |
942 |
_2ddc _cBK |
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999 |
_c206325 _d206325 |