000 05462cam a2200853Ia 4500
001 ocn823389939
003 OCoLC
005 20171112123948.0
006 m o d
007 cr |n|||||||||
008 121227s2013 njuaf ob 001 0 eng d
020 _a9781118516157
020 _a111851615X
020 _a9781118516126
020 _a1118516125
020 _a9781283917520
020 _a1283917521
020 _z9780470942383
020 _z047094238X
029 1 _aAU@
_b000050590993
029 1 _aDEBBG
_bBV041049285
029 1 _aDEBBG
_bBV041829130
029 1 _aDEBBG
_bBV041908799
029 1 _aNZ1
_b15194662
029 1 _aNZ1
_b15340440
035 _a(OCoLC)823389939
_z(OCoLC)836200869
_z(OCoLC)860794225
037 _a10.1002/9781118516157
_bWiley InterScience
_nhttp://www3.interscience.wiley.com
040 _aMHW
_beng
_epn
_cMHW
_dOCLCO
_dEBLCP
_dDG1
_dN$T
_dYDXCP
_dMYG
_dCDX
_dIDEBK
_dIUL
_dE7B
_dNOC
_dOCLCO
_dOCLCF
_dOCLCQ
_dRECBK
_dU3G
_dUKDOC
_dDEBBG
_dCOO
_dOCLCQ
049 _aMAIN
050 4 _aRS189.5.S65
_bM37 2013eb
060 4 _aQV 744
072 7 _aMED
_x023000
_2bisacsh
072 7 _aMED
_x058170
_2bisacsh
072 7 _aMED
_x071000
_2bisacsh
072 7 _aMED
_x072000
_2bisacsh
082 0 4 _a615.1
_a615.19
245 0 0 _aMass spectrometry for drug discovery and drug development /
_cedited by Walter A. Korfmacher.
_h[electronic resource]
260 _aHoboken, N.J. :
_bWiley,
_c2013.
300 _a1 online resource (xii, 461 pages, [16] pages of plates)) :
_billustrations (some color).
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aWiley series on mass spectrometry
504 _aIncludes bibliographical references and index.
505 0 _a1. Overview of the various types of mass spectrometers that are used in drug discovery and drug development / Gerard Hopfgartner -- 2. Utility of high resolution mass spectrometry for new drug discovery applications / William Bart Emary and Nanyan Rena Zhang -- 3. Quantitative mass spectrometry considerations in a regulated environment / Mohammed Jemal and Yuan-Qing Xia -- 4. Mass spectrometry for quantitative in vitro ADME assays / Jun Zhang and Wilson Z. Shou -- 5. Metabolite identification using mass spectrometry in drug development / Natalia Penner, Joanna Zgoda-Pols, and Chandra Prakash -- 6. MS analysis of biological drugs, proteins, and peptides / Yi Du, John Mehl, and Pavlo Pristatsky -- 7. Characterization of impurities and degradation products in small molecule pharmaceuticals and biologics / Hui Wei, Guodong Chen and Adrienne A. Tymiak -- 8. Liquid extraction surface analysis (LESA) : a new mass spectrometry-based technique for ambient surface profiling / Dan Eikel and Jack Henion -- 9. MS applications in support of medicinal chemistry sciences / Maarten Honing, Benno Ingelse, and Birendraÿ N. Pramanik -- 10. Imaging mass spectrometry of proteins and peptides / Michelle L. Reyzer and Richard M. Caprioli -- 11. Imaging mass spectrometry for drugs and metabolites / Stacey R. Oppenheimer -- 12. Screening reactive metabolites : role of liquid chromatography-high resolution mass spectrometry in combination with 'intelligent' data mining tools / Shuguang Ma and Swapan K. Chowdhury -- 13. Mass spectrometry of siRNA / Mark Cancilla and Mike Flanagan -- 14. Mass spectrometry for metabolomics / Petia Shipkova and Michael D. Reily -- 15. Quantitative analysis of peptides with mass spectrometry : selected reaction monitoring or high resolution full scan? / Lieve Dillen and Filip Cuyckens.
520 _aThis book presents a summary of the ways mass spectrometry is used in various stages of drug discovery and development including early support of medicinal chemistry, drug metabolism studies, distribution, degradation, and various development assays. The book includes a balance of basic and advanced information. Specific chapters relate to various stages in the process (e.g., discovery) as well as chapters on topics of current interest (lipidomics and SiRNA) are covered.
588 0 _aPrint version record.
650 0 _aDrugs
_xAnalysis.
650 0 _aDrug development.
650 0 _aMass spectrometry.
650 1 2 _aDrug Discovery.
650 1 2 _aMass Spectrometry
_xmethods.
650 2 2 _aPeptides
_xanalysis.
650 2 2 _aPharmaceutical Preparations
_xanalysis.
650 2 2 _aProteins
_xanalysis.
650 4 _aDrug discovery.
650 4 _aMass spectrometry
_xMethods.
650 4 _aPeptides
_xAnalysis.
650 4 _aPharmaceutical preparations
_xAnalysis.
650 4 _aProteins
_xAnalysis.
650 7 _aMEDICAL
_xDrug Guides.
_2bisacsh
650 7 _aMEDICAL
_xNursing
_xPharmacology.
_2bisacsh
650 7 _aMEDICAL
_xPharmacology.
_2bisacsh
650 7 _aMEDICAL
_xPharmacy.
_2bisacsh
650 7 _aDrug development.
_2fast
_0(OCoLC)fst00898670
650 7 _aDrugs
_xAnalysis.
_2fast
_0(OCoLC)fst00898769
650 7 _aMass spectrometry.
_2fast
_0(OCoLC)fst01011435
655 4 _aElectronic books.
700 1 _aKorfmacher, Walter A.
776 0 8 _iPrint version:
_tMass spectrometry for drug discovery and drug development.
_dHoboken, N.J. : John Wiley & Sons, ©2013
_z9780470942383
_w(DLC) 2012031775
_w(OCoLC)806291832
830 0 _aWiley-Interscience series on mass spectrometry.
856 4 0 _uhttp://onlinelibrary.wiley.com/book/10.1002/9781118516157
_zWiley Online Library
942 _2ddc
_cBK
999 _c206325
_d206325