000			05306cam a2200841 i 4500
001			ocn861789137
003			OCoLC
005			20171106082202.0
006			m o d
007			cr |||||||||||
008			131029s2014 njua ob 000 0 eng
010			_a 2013043100
020			_a9781118836323 _q(pdf)
020			_a1118836324 _q(pdf)
020			_a9781118836309 _q(epub)
020			_a1118836308 _q(epub)
020			_a9781118836538 _q(mobi)
020			_a1118836537 _q(mobi)
020			_a9781118836507 _q(electronic bk.)
020			_a1118836502 _q(electronic bk.)
020			_z9780470566688 _q(cloth)
020			_a047056668X
020			_a9780470566688
029	1		_aAU@ _b000052169909
029	1		_aNZ1 _b15497427
029	1		_aNZ1 _b15906674
029	1		_aCHVBK _b334094607
029	1		_aCHBIS _b010442024
029	1		_aDEBSZ _b431651698
029	1		_aNZ1 _b16092114
029	1		_aDEBBG _bBV042793875
029	1		_aDEBBG _bBV042989477
029	1		_aDEBBG _bBV043396304
035			_a(OCoLC)861789137 _z(OCoLC)905856765
040			_aDLC _beng _erda _epn _cDLC _dYDX _dEBLCP _dIDEBK _dDG1 _dN$T _dE7B _dCUS _dCDX _dOCLCF _dVRC _dYDXCP _dRECBK _dNLGGC _dOCLCQ _dOCLCO _dCOO _dDEBSZ _dDEBBG
042			_apcc
049			_aMAIN
050	0	0	_aQP370
060	1	0	_aQU 136
072		7	_aMED _x075000 _2bisacsh
072		7	_aSCI _x036000 _2bisacsh
082	0	0	_a612.8/2 _223
245	0	0	_aCyclic-nucleotide phosphodiesterases in the central nervous system : from biology to drug discovery / _cedited by Nicholas J. Brandon, Anthony R. West. _h[electronic resource]
264		1	_aHoboken, New Jersey : _bJohn Wiley & Sons, Inc., _c[2014]
300			_a1 online resource (xi, 386 pages) : _billustrations (some color).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aWiley series in drug discovery and development
504			_aIncludes bibliographical references.
505	0		_aPhosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P.P. Bollen, Kris Rutten, Olga A.H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin.
588	0		_aPrint version record and CIP data provided by publisher.
650		0	_aCyclic nucleotide phosphodiesterases.
650		0	_aCentral nervous system _xPhysiology.
650		0	_aNucleotides, Cyclic.
650		2	_a3',5'-Cyclic-AMP Phosphodiesterases _xmetabolism.
650		2	_a3',5'-Cyclic-AMP Phosphodiesterases _xtherapeutic use.
650		2	_aCentral Nervous System _xphysiology.
650		2	_aCentral Nervous System Diseases _xdrug therapy.
650		2	_aDrug Discovery.
650		7	_aMEDICAL _xPhysiology. _2bisacsh
650		7	_aSCIENCE _xLife Sciences _xHuman Anatomy & Physiology. _2bisacsh
650		7	_aCentral nervous system. _2fast _0(OCoLC)fst00850724
650		7	_aCyclic nucleotide phosphodiesterases. _2fast _0(OCoLC)fst00885846
655		4	_aElectronic books.
655		0	_aElectronic books.
700	1		_aBrandon, Nicholas J., _eeditor.
700	1		_aWest, Anthony R., _d1970- _eeditor.
776	0	8	_iPrint version: _tCyclic-nucleotide phosphodiesterases in the central nervous system. _dHoboken, New Jersey : John Wiley & Sons, Inc., [2014] _z9780470566688 _w(DLC) 2013042742 _w(OCoLC)861755359
830		0	_aWiley series in drug discovery and development.
856	4	0	_uhttp://onlinelibrary.wiley.com/book/10.1002/9781118836507 _zWiley Online Library
942			_2ddc _cBK
999			_c207057 _d207057