000			06110cam a2200877 i 4500
001			ocn867001327
003			OCoLC
005			20171031134430.0
006			m o d
007			cr |||||||||||
008			131230s2014 nju ob 001 0 eng
010			_a 2013051091
016	7		_a016683246 _2Uk
020			_a9781118501658 (epub)
020			_a1118501659 (epub)
020			_a9781118501641 (pdf)
020			_a1118501640 (pdf)
020			_z9781118501627 (hardback)
020			_a9781118501665
020			_a1118501667
020			_a1306473551
020			_a9781306473552
020			_a1118501624
020			_a9781118501627
029	1		_aNZ1 _b15497379
029	1		_aCHVBK _b330903020
029	1		_aCHDSB _b006350722
029	1		_aNZ1 _b15906654
029	1		_aNZ1 _b16092123
029	1		_aDEBBG _bBV042796336
035			_a(OCoLC)867001327 _z(OCoLC)871633036 _z(OCoLC)927508391 _z(OCoLC)940437378 _z(OCoLC)961547303 _z(OCoLC)962573345
037			_a578606 _bMIL
040			_aDLC _beng _erda _cDLC _dYDX _dEBLCP _dDG1 _dE7B _dN$T _dCUS _dIDEBK _dUKMGB _dYDXCP _dOHI _dCDX _dRECBK _dNLGGC _dOCLCO _dCHVBK _dCOO _dDEBBG _dOCLCF
042			_apcc
049			_aMAIN
050	0	0	_aRC268.4
060	1	0	_aQZ 266
072		7	_aHEA _x039000 _2bisacsh
072		7	_aMED _x014000 _2bisacsh
072		7	_aMED _x022000 _2bisacsh
072		7	_aMED _x112000 _2bisacsh
072		7	_aMED _x045000 _2bisacsh
082	0	0	_a616.99/4042 _223
245	0	0	_aCancer gene therapy by viral and non-viral vectors / _cedited by Malcolm K. Brenner, Mien-Chie Hung. _h[electronic resource]
264		1	_aHoboken, New Jersey : _bWiley Blackwell, _c[2014]
300			_a1 online resource.
336			_atext _2rdacontent
337			_acomputer _2rdamedia
338			_aonline resource _2rdacarrier
490	1		_aTranslational oncology ; _v4
500			_aMachine generated contents note: ContributorsSeries ForewordPreface Part I: Delivery Systems 1. Translational Cancer Research: Gene Therapy by Viral and Non-viral Vectors Vincenzo Cerullo, Kilian Guse, Markus Vaha-Koskela and Akseli Hemminki 2. Retroviruses for Cancer Therapy Jiehua Zhou, Yue Ding, John Burnett and John Rossi 3. DNA Plasmids for Non-viral Gene Therapy of Cancer Amer N. Najjar, Judy S.E. Moyes and Laurence J.N. Cooper 4. Cancer Therapy with RNAi delivered by Nonviral Membrane/Core Nanoparticles Andrew B. Satterlee and Leaf Huang Part II: Targeted Expression 5. Cancer Gene Therapy by Tissue-specific and Cancer-targeting Promoters Jennifer L. Hsu, Longfei Huo, Chia-Wei Li, Yi-Hsin Hsu, Yan Wang and Mien-Chie Hung 6. MicroRNAs as Drugs and Drug Targets in Cancer Hui Ling and George A. Calin Part III: Principles of Clinical Trials in Gene Therapy 7. Regulatory Issues for Manufacturers of Viral Vectors and Vector-Transduced Cells for Phase I/II Trials Adrian P. Gee and Zhuyong Mei 8. U.S. Regulations Governing Clinical Trials in Gene Therapy Bambi Grilley 9. Remaining Obstacles to the Success of Cancer Gene Therapy Malcolm K. BrennerIndex.
504			_aIncludes bibliographical references and index.
520			_a"Translational medicine has opened the gateway to the era of personalized medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. Gene therapy in cancer has faced many technical barriers in the past but has recently shown significant progress that could allow stem cell and gene transfer therapies to make a major contribution to cancer therapy. The time appears ripe for a good, authoritative, book-length review of the state-of-the-art in this field. Gene Therapy by Viral and Non-viral Vectors provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains the clinical ramifications and utility of these on gene-based cancer therapies. Designed as a volume in the book series Translational Oncology, edited by Robert Bast, Maurie Markman, and Ernest Hawk, this new book deals with the practice of gene therapy with reference to vectors for gene expression and gene transfer as well as viral therapy, and it will very nicely complement other books in the series, especially the volumes on immunotherapy and cell therapy. The content of the book also covers the history and current and future applications of gene transfer in cancer. This new volume provides expert insight on the current progress of viral and nonviral gene therapy with regard to delivery system, vector design, potential therapeutic genes, and principles and regulations for cancer gene therapy. It offers important and immediately applicable information to investigators, clinician-researchers, and medcial and graduate students with interest in this vital area of research"--Provided by publisher.
588			_aDescription based on print version record and CIP data provided by publisher.
650		0	_aCancer _xGene therapy.
650		0	_aGenetic vectors _xTherapeutic use.
650		7	_aHEALTH & FITNESS _xDiseases _xGeneral. _2bisacsh
650		7	_aMEDICAL _xClinical Medicine. _2bisacsh
650		7	_aMEDICAL _xDiseases. _2bisacsh
650		7	_aMEDICAL _xEvidence-Based Medicine. _2bisacsh
650		7	_aMEDICAL _xInternal Medicine. _2bisacsh
650		2	_aNeoplasms _xtherapy.
650		2	_aGenetic Therapy.
650		2	_aGenetic Vectors _xtherapeutic use.
650		2	_aOncolytic Virotherapy.
650		4	_aGenetic Therapy.
650		7	_aGene therapy. _2fast _0(OCoLC)fst00939638
655		4	_aElectronic books.
655		0	_aElectronic books.
700	1		_aBrenner, Malcolm K., _d1951- _eeditor of compilation.
700	1		_aHung, Mien-chie, _eeditor of compilation.
776	0	8	_iPrint version: _tCancer gene therapy by viral and non-viral vectors _dHoboken, New Jersey : John Wiley & Sons, [2014] _z9781118501627 _w(DLC) 2013049552
830		0	_aTranslational oncology (Series) ; _v4.
856	4	0	_uhttp://onlinelibrary.wiley.com/book/10.1002/9781118501665 _zWiley Online Library
942			_2ddc _cBK
999			_c207179 _d207179