| 000 | 06812cam a2200733 i 4500 | ||
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| 001 | ocn879851949 | ||
| 003 | OCoLC | ||
| 005 | 20171030102614.0 | ||
| 006 | m o d | ||
| 007 | cr ||||||||||| | ||
| 008 | 140514s2014 nju ob 001 0 eng | ||
| 010 | _a 2014019036 | ||
| 020 |
_a9781118876022 _q(epub) |
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_a1118876024 _q(epub) |
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| 020 |
_a9781118876091 _q(pdf) |
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| 020 |
_a1118876091 _q(pdf) |
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| 020 | _a9781118876015 | ||
| 020 | _a1118876016 | ||
| 020 |
_a1118466616 _q(hardback) |
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| 020 |
_a9781118466612 _q(hardback) |
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| 020 |
_z9781118466612 _q(hardback) |
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_a(OCoLC)879851949 _z(OCoLC)893685368 _z(OCoLC)933561027 _z(OCoLC)959871329 _z(OCoLC)961611452 _z(OCoLC)962662548 |
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| 040 |
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| 049 | _aMAIN | ||
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_aNatural products analysis : instrumentation, methods, and applications / _cedited by Vladimir Havlicek, Laboratory of Molecular Structure Cjaracterization, Academy of Sciences of the Czech Republick, Prague, Czech Republic, Jaroslav Spizek, Laboratory of Physiology and Genetics of Actinomycetes, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic. _h[electronic resource] |
| 264 | 1 |
_aHoboken, New Jersey : _bWiley, _c2014. |
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| 300 | _a1 online resource. | ||
| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 504 | _aIncludes bibliographical references and index. | ||
| 505 | 0 | _aNatural Products Analysis: Instrumentation, Methods,and Applications; Copyright; Contents; Preface; Contributors; Chapter 1 Natural Products Analysis: Instrumentation, Methods, and Applications; 1.1 Book Motivation; 1.2 The Broad Field of Natural Products; 1.3 Discovery Phases; 1.4 Absolute Structure; 1.5 Mass Spectral Applications in Concert; 1.6 Complex Structures and Complex Mixtures; References; Chapter 2 The Need for New Antifungal and Antimalarial Compounds; 2.1 Introduction; 2.2 Fungal Infections; 2.2.1 Fungal Diseases; 2.2.2 Antifungal Therapy; 2.2.3 Fluoropyrimidines; 2.2.4 Azoles | |
| 505 | 8 | _a2.2.5 Echinocandins2.2.6 Other Peptides; 2.2.7 Polyenes; 2.2.8 Miscellaneous Antifungals; 2.3 Malaria; 2.3.1 The Disease; 2.3.2 Quinine; 2.3.3 Artemisinin; 2.3.4 Tetracyclines; 2.3.5 Clindamycin; 2.3.6 Combinations of Drugs; 2.4 Conclusions; References; Chapter 3 Emerging Instrumental Methods for Antimicrobial Resistance and Virulence Testing; 3.1 Introduction; 3.2 Mass Spectrometry; 3.3 Nucleic Acid Amplification and Sequencing; 3.4 Perspective; Acknowledgment; References; Chapter 4 Plant and Marine Sources: Biological Activity of Natural Products and Therapeutic Use; 4.1 Introduction | |
| 505 | 8 | _a4.2 Significance of Plant Sources4.2.1 Methods Used in Chemistry of Plant-Derived Products; 4.2.2 Chemistry and the Modes of Action of Plant Metabolites; 4.3 Impact of Marine Natural Products; 4.3.1 Marine Chemical Biology; 4.4 Natural Products and Diseases; 4.4.1 Endocrine System-Diabetes; 4.4.2 Cardiovascular Ailments; 4.4.3 Antiplatelet and Antisclerotic Drugs; 4.4.4 Diseases Correlated with Problems of the Central Nervous System (CNS); 4.4.5 Plants Used Against the Respiratory Disorders; 4.4.6 Infectious Diseases and the Use of Plant- or Marine-Derived Drugs | |
| 505 | 8 | _a4.4.7 Anticancer Drugs from Plants and Marine Sources4.5 Conclusions; References; Chapter 5 Emerging Trends for Stimulating the Discovery of Natural Products; 5.1 Mass Spectrometry-Based Metabolomics; 5.2 Metagenomics and Symbiosis; 5.3 Bioinformatic Annotation of Biosynthetic Pathways and Structure Prediction; 5.4 New Tools For Absolute Configuration Determination; References; Chapter 6 Advances and Challenges in Optical Molecular Spectroscopy Including Surface Plasmon Resonance-Based Methods for Bioanalysis; 6.1 Introduction to Principles and Analytical Aspects of Optical Spectroscopy | |
| 505 | 8 | _a6.1.1 Description of Electromagnetic Radiation and Its Propagation6.1.2 Light Absorption and the Beer-Lambert-Bouguer Law; 6.1.3 Deviations from the Beer-Lambert-Bouguer Law; 6.1.4 Calibration Methods in Optical Spectroscopy; 6.1.5 Multivariate Quantitative Models; 6.1.6 Multivariate Classification Models; 6.2 Molecular Spectroscopy and Its Instrumentation; 6.2.1 Types of Molecular Optical Spectroscopic Methods; 6.2.2 General Types of Instrumentation; 6.2.3 Electronic States and Electronic Spectroscopy; 6.2.4 Vibrational States and Methods of Vibrational Spectroscopy | |
| 520 |
_a"This book highlights analytical chemistry instrumentation and practices applied to the analysis of natural products and their complex mixtures, describing techniques for isolating and characterizing natural products. Applies analytical techniques to natural products research - an area of critical importance to drug discovery Offers a one-stop shop for most analytical methods: X-ray diffraction, NMR analysis, mass spectrometry, and chemical genetics Includes coverage of natural products basics and highlights antibacterial research, particularly important as efforts to combat drug resistance gain prominence Covers instrumental techniques with enough detail for both current practitioners and beginning researchers"-- _cProvided by publisher. |
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| 520 |
_a"This book highlights analytical chemistry instrumentation and practices applied to the analysis of natural products and their complex mixtures, describing techniques for isolating and characterizing natural products"-- _cProvided by publisher. |
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| 546 | _aText in English. | ||
| 588 | 0 | _aPrint version record and CIP data provided by publisher. | |
| 650 | 0 |
_aNatural products _xAnalysis. |
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| 650 | 0 | _aChemistry, Analytic. | |
| 650 | 7 |
_aSCIENCE _xChemistry _xOrganic. _2bisacsh |
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| 650 | 7 |
_aSCIENCE _xLife Sciences _xBiology _xMicrobiology. _2bisacsh |
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| 650 | 7 |
_aSCIENCE _xChemistry _xAnalytic. _2bisacsh |
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| 650 | 7 |
_aChemistry, Analytic. _2fast _0(OCoLC)fst00853459 |
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| 650 | 7 |
_aNatural products _xAnalysis. _2fast _0(OCoLC)fst01034391 |
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| 655 | 4 | _aElectronic books. | |
| 700 | 1 |
_aHavlíček, Vladimír, _eeditor. |
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| 700 | 1 |
_aSpižek, Jaroslav, _eeditor. |
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| 776 | 0 | 8 |
_iPrint version: _tNatural products analysis. _dHoboken, New Jersey : Wiley, 2014 _z9781118466612 _w(DLC) 2014008371 |
| 856 | 4 | 0 |
_uhttp://onlinelibrary.wiley.com/book/10.1002/9781118876015 _zWiley Online Library |
| 942 |
_2ddc _cBK |
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| 999 |
_c207442 _d207442 |
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