000 06177cam a2200745Ii 4500
001 ocn885212593
003 OCoLC
005 20171026132824.0
006 m o d
007 cr cnu---unuuu
008 140804s2014 gw a ob 001 0 eng d
020 _a9783527683345
_qelectronic bk.
020 _a3527683348
_qelectronic bk.
020 _a9783527683352
_qelectronic bk.
020 _a3527683356
_qelectronic bk.
020 _a9783527683338
_qelectronic bk.
020 _a352768333X
_qelectronic bk.
020 _a9783527683321
_qelectronic bk.
020 _a3527683321
_qelectronic bk.
020 _z9783527335473
020 _z3527335471
029 1 _aNZ1
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029 1 _aDEBSZ
_b431727546
029 1 _aGBVCP
_b814608817
029 1 _aDEBSZ
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029 1 _aDEBBG
_bBV043397017
035 _a(OCoLC)885212593
_z(OCoLC)884646511
040 _aN$T
_beng
_erda
_epn
_cN$T
_dYDXCP
_dDG1
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_dCOO
_dCDX
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_dEBLCP
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_dDEBBG
049 _aMAIN
050 4 _aTP248.27.M53
072 7 _aSCI
_x013060
_2bisacsh
072 7 _aTEC
_x009010
_2bisacsh
082 0 4 _a660.62
_223
245 0 0 _aIndustrial scale suspension culture of living cells /
_cedited by Hans-Peter Meyer and Diego R. Schmidhalter.
_h[electronic resource]
264 1 _aWeinheim, Germany :
_bWiley Blackwell,
_c[2014]
300 _a1 online resource (xxix, 612 pages) :
_billustrations (black and white, and colour)
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
504 _aIncludes bibliographical references and index.
505 0 _aIndustrial Scale Suspension Culture of Living Cells; Forword; Contents; Preface; List of Contributors; The History and Economic Relevance of Industrial Scale Suspension Culture of Living Cells; 1 Introduction; 2 A Short History of Suspension Culture (Fermentation); 2.1 Ethanol, Organic Acids, and Solvents, the Beginning; 2.2 Vitamins Fermentation Takes a Long Time to Develop; 2.3 Steroids, the First Large-Scale Biocatalysis Processes; 2.4 Antibiotics, a US-Lead Turning Point in Fermentation Technology; 2.5 Amino Acids, a Japanese Fermentation Success Story.
505 8 _a2.6 Enzymes, a European Fermentation Success Story2.7 Single Cell Proteins, an Economic Flop; 2.8 Biofuels are Controversial Story; 2.9 Recombinant DNA Technology Based Products (Monoclonal Antibodies and Other Recombinant Proteins), Setting off an Avalanche of New Products; 3 The Contemporary Situation; 3.1 How Long Can the USA Keep its Leading Role?; 3.2 China and India Become Global Forces in Fermentation; 4 The Future of Suspension Culture; 4.1 New Frontiers; 4.2 Yet "Uncultured" Cells and Organisms?; 5 Economic and Market Considerations; 5.1 The Pharmaceutical Market.
505 8 _a5.2 Personal Care Products5.3 Chemicals, Industrial and Technical Enzymes; 5.4 Food, Dietary Supplements (Functional Food, Nutraceuticals), and Feed Products; 6 Conclusions; References; Part I: Suspension Culture of Bacteria, Yeasts, and Filamentous Fungi; 1 Bacterial Suspension Cultures; 1.1 Introduction; 1.2 Organisms, Cells, and their Products; 1.2.1 Bacteria as Production Platform for Various Products; 1.2.2 Historical Outline for Escherichia coli; 1.2.3 Industrial Aspects of Bacterial Expression Systems; 1.3 Bioprocess Design Aspects for Recombinant Products.
505 8 _a1.3.1 Bacterial Cultivation Processes1.3.2 Gram Negative Cell Factory: Cellular Compartments and Transport across Membranes; 1.3.3 Industrial Strategies: Quality, Folding State, and Location of Recombinant Protein Products; 1.3.4 Approaches towards Bioprocess Design, Optimization, and Manufacturing; 1.3.5 Bacterial Bioprocess Design; 1.3.5.1 Technical and Physiological Constraints for Bacterial Bioprocess Design; 1.3.5.2 Media Design; 1.3.5.3 Product Titer is Determined by the Biomass Concentration and the Specific Productivity qp; 1.3.6 Industrial Production Strategy by Two-Step Cultivation.
505 8 _a1.3.6.1 Batch Phase for the Accumulation of Biomass1.3.6.2 Structured Approach Towards Batch Design; 1.3.6.3 Fed-Batch Phase Process Design from Scratch; 1.3.6.4 Induction Phase: Product Formation Characteristics; 1.3.6.5 Process Parameters Impacting Recombinant Product Formation; 1.3.6.6 Concept of Time-Space Yield; 1.4 Basic Bioreactor Design Aspects; 1.4.1 Introduction; 1.4.2 Vessel Design and Construction; 1.4.3 Dimensioning; 1.4.3.1 Materials of Construction; 1.4.3.2 Surface Quality and Welding; 1.4.3.3 Nozzles and Ports; 1.4.4 Mass Transfer; 1.4.5 Cleaning in Place.
520 _aThe submersed cultivation of organisms in sterile containments or fermenters has become the standard manufacturing procedure, and will remain the gold standard for some time to come. This book thus addresses submersed cell culture and fermentation and its importance for the manufacturing industry. It goes beyond expression systems and integrally investigates all those factors relevant for manufacturing using suspension cultures. In so doing, the contributions cover all industrial cultivation methods in a comprehensive and comparative manner, with most of the authors coming from the industry.
588 _aDescription based on print version record.
650 0 _aCell culture.
650 0 _aIndustrial microbiology.
650 0 _aBiotechnology.
650 7 _aSCIENCE / Chemistry / Industrial & Technical
_2bisacsh
650 7 _aTECHNOLOGY & ENGINEERING / Chemical & Biochemical
_2bisacsh
650 7 _aBiotechnology.
_2fast
_0(OCoLC)fst00832729
650 7 _aCell culture.
_2fast
_0(OCoLC)fst00850172
650 7 _aIndustrial microbiology.
_2fast
_0(OCoLC)fst00971352
650 4 _aGene Expression.
650 4 _aGenetic engineering.
655 4 _aElectronic books.
655 0 _aElectronic books.
700 1 _aMeyer, Hans-Peter,
_eeditor.
700 1 _aSchmidhalter, Diego R.,
_eeditor.
776 0 8 _iPrint version:
_tIndustrial scale suspension culture of living cells
_z9783527335473
_w(OCoLC)883376391
856 4 0 _uhttp://onlinelibrary.wiley.com/book/10.1002/9783527683321
_zWiley Online Library
942 _2ddc
_cBK
999 _c207599
_d207599