000			02184nam a22003618a 4500
001			CR9780511760334
003			UkCbUP
005			20171019114422.0
006			m|||||o||d||||||||
007			cr||||||||||||
008			100506s2010||||enk s ||1 0|eng|d
020			_a9780511760334 (ebook)
020			_z9780521112086 (hardback)
040			_aUkCbUP _cUkCbUP _erda
050	0	0	_aQP552.G16 _bG1747 2011
082	0	0	_a572/.696 _222
245	0	0	_aG Protein-Coupled Receptors : _bStructure, Signaling, and Physiology / _cEdited by Sandra Siehler, Graeme Milligan.
264		1	_aCambridge : _bCambridge University Press, _c2010.
300			_a1 online resource (446 pages) : _bdigital, PDF file(s).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
500			_aTitle from publisher's bibliographic system (viewed on 09 Oct 2015).
520			_aProvides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field.
650		0	_aG proteins
650		0	_aCell receptors
650		0	_aCellular signal transduction
650		0	_aDrug Delivery Systems
700	1		_aSiehler, Sandra, _eeditor of compilation.
700	1		_aMilligan, Graeme, _eeditor of compilation.
776	0	8	_iPrint version: _z9780521112086
856	4	0	_uhttp://dx.doi.org/10.1017/CBO9780511760334
999			_c225336 _d225336