000 02184nam a22003618a 4500
001 CR9780511760334
003 UkCbUP
005 20171022143247.0
006 m|||||o||d||||||||
007 cr||||||||||||
008 100506s2010||||enk s ||1 0|eng|d
020 _a9780511760334 (ebook)
020 _z9780521112086 (hardback)
040 _aUkCbUP
_cUkCbUP
_erda
050 0 0 _aQP552.G16
_bG1747 2011
082 0 0 _a572/.696
_222
245 0 0 _aG Protein-Coupled Receptors :
_bStructure, Signaling, and Physiology /
_cEdited by Sandra Siehler, Graeme Milligan.
264 1 _aCambridge :
_bCambridge University Press,
_c2010.
300 _a1 online resource (446 pages) :
_bdigital, PDF file(s).
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
500 _aTitle from publisher's bibliographic system (viewed on 09 Oct 2015).
520 _aProvides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field.
650 0 _aG proteins
650 0 _aCell receptors
650 0 _aCellular signal transduction
650 0 _aDrug Delivery Systems
700 1 _aSiehler, Sandra,
_eeditor of compilation.
700 1 _aMilligan, Graeme,
_eeditor of compilation.
776 0 8 _iPrint version:
_z9780521112086
856 4 0 _uhttp://dx.doi.org/10.1017/CBO9780511760334
999 _c229424
_d229424