000			02131nam a22003378a 4500
001			CR9780511736179
003			UkCbUP
005			20180107143412.0
006			m|||||o||d||||||||
007			cr||||||||||||
008			100329s2011||||enk s ||1 0|eng|d
020			_a9780511736179 (ebook)
020			_z9781107001596 (hardback)
040			_aUkCbUP _cUkCbUP _erda
050	0	0	_aQH324.2 _b.P352 2011
082	0	0	_a572.80285 _222
100	1		_aPalsson, Bernhard Ø., _eauthor.
245	1	0	_aSystems Biology: Simulation of Dynamic Network States / [electronic resource] _cBernhard Ø. Palsson.
264		1	_aCambridge : _bCambridge University Press, _c2011.
300			_a1 online resource (332 pages) : _bdigital, PDF file(s).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
500			_aTitle from publisher's bibliographic system (viewed on 09 Oct 2015).
520			_aBiophysical models have been used in biology for decades, but they have been limited in scope and size. In this book, Bernhard Ø. Palsson shows how network reconstructions that are based on genomic and bibliomic data, and take the form of established stoichiometric matrices, can be converted into dynamic models using metabolomic and fluxomic data. The Mass Action Stoichiometric Simulation (MASS) procedure can be used for any cellular process for which data is available and allows a scalable step-by-step approach to the practical construction of network models. Specifically, it can treat integrated processes that need explicit accounting of small molecules and protein, which allows simulation at the molecular level. The material has been class-tested by the author at both the undergraduate and graduate level. All computations in the text are available online in MATLAB and MATHEMATICA® workbooks, allowing hands-on practice with the material.
650		0	_aComputational biology
650		0	_aGenomics
650		0	_aBioinformatics
776	0	8	_iPrint version: _z9781107001596
856	4	0	_uhttp://dx.doi.org/10.1017/CBO9780511736179 _zCambridge Books Online
999			_c236509 _d236509