000 03028cam a2200481Ki 4500
001 ocn889675352
003 OCoLC
005 20190328114808.0
006 m o d
007 cr cnu---unuuu
008 140830s2013 enka ob 001 0 eng d
040 _aEBLCP
_beng
_epn
_cEBLCP
_dOCLCO
_dN$T
_dGZM
_dMYG
_dUIU
_dOCLCF
_dOPELS
_dOCLCQ
_dU3W
_dD6H
020 _a9781908818287
_q(electronic bk.)
020 _a190881828X
_q(electronic bk.)
020 _z9781907568213
_q(print)
035 _a(OCoLC)889675352
050 4 _aRM301.25
072 7 _aMED
_x071000
_2bisacsh
082 0 4 _a615.19
100 1 _aLai, Yurong.
245 1 0 _aTransporters in drug discovery and development : detailed concepts and best practice /
_h[electronic resource]
_cYurong Lai.
260 _aOxford :
_bElsevier Science,
_c2013.
300 _a1 online resource (xxiii, 734 pages) :
_billustrations.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aWoodhead Publishing Series in Biomedicine
504 _aIncludes bibliographical references and index.
588 0 _aPrint version of record.
505 0 _aMembrane transporters and the diseases corresponding to functional defects -- P-glycoprotein (P-gp/MDR1)/ABCB1 -- Multidrug resistanceassociated protein 2 (MRP2/ABCC2) -- Breast cancer resistance protein (BCRP)/ABCG2 -- The bile salt export pump (BSEP/ABCB11) -- Organic aniontransporting polypeptides (OATPs/SLCOs) -- Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs) -- Drug transporters in drug discovery and development -- 9 Transporter study methodologies.
500 _aWritten by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery.
650 0 _aBiopharmaceutics.
650 0 _aDrug development.
650 0 _aDrugs
_xDesign.
650 7 _aMEDICAL
_xPharmacology.
_2bisacsh
650 7 _aBiopharmaceutics.
_2fast
_0(OCoLC)fst00832650
650 7 _aDrug development.
_2fast
_0(OCoLC)fst00898670
650 7 _aDrugs
_xDesign.
_2fast
_0(OCoLC)fst00898790
655 4 _aElectronic books.
776 0 8 _iPrint version:
_aLai, Yurong.
_tTransporters in Drug Discovery and Development : Detailed Concepts and Best Practice.
_dBurlington : Elsevier Science, �2013
_z9781907568213
830 0 _aWoodhead Publishing series in biomedicine.
856 4 0 _3ScienceDirect
_uhttp://www.sciencedirect.com/science/book/9781907568213
999 _c246950
_d246950