000 06176cam a2200709Mi 4500
001 ocn890162866
003 OCoLC
005 20190328114808.0
006 m o d
007 cr |||||||||||
008 140915s2014 enk o 000 0 eng d
010 _a 2014950424
040 _aUKMGB
_beng
_erda
_epn
_cUKMGB
_dN$T
_dOPELS
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016 7 _a016869524
_2Uk
016 7 _a016856985
_2Uk
019 _a898422306
_a1066443727
_a1088966405
020 _a9781908818683
_q(electronic bk.)
020 _a1908818689
_q(electronic bk.)
020 _z9781907568473
_q(hbk.)
020 _z1907568476 (print)
035 _a(OCoLC)890162866
_z(OCoLC)898422306
_z(OCoLC)1066443727
_z(OCoLC)1088966405
050 4 _aRC661.I6
_bS66 2014
060 0 0 _a2015 A-997
060 1 0 _aWK 820
072 7 _aHEA
_x039000
_2bisacsh
072 7 _aMED
_x014000
_2bisacsh
072 7 _aMED
_x022000
_2bisacsh
072 7 _aMED
_x112000
_2bisacsh
072 7 _aMED
_x045000
_2bisacsh
082 0 4 _a616.462061
_223
100 1 _aSonia, Thundiparambil Azeez,
_eauthor.
245 1 0 _aOral delivery of insulin /
_h[electronic resource]
_cThundiparambil Azeez Sonia, Chandra P. Sharma.
264 1 _aOxford :
_bWoodhead Publishing,
_c2014.
300 _a1 online resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aWoodhead publishing series in biomedicine ;
_vnumber 41
588 0 _aCIP data; item not viewed.
520 _aDiabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin.
505 0 0 _gMachine generated contents note:
_g1.
_tDiabetes mellitus -- an overview --
_g1.1.
_tDiabetes mellitus -- an introduction --
_g1.2.
_tGlucose homeostasis --
_g1.3.
_tTypes of diabetes --
_g1.4.
_tSymptoms of diabetes --
_g1.5.
_tComplications of diabetes --
_g1.6.
_tDiagnosis of diabetes mellitus --
_g1.7.
_tTherapy for diabetes --
_g1.8.
_tNon-insulin treatment options of type 1 diabetes --
_g1.9.
_tTreatment options of type 2 diabetes --
_g1.10.
_tConclusion --
_g1.11.
_tReferences --
_g2.
_tRoutes of administration of insulin --
_g2.1.
_tCurrent approach for the delivery of insulin --
_g2.2.
_tRoutes of administration of insulin --
_g2.3.
_tConclusion --
_g2.4.
_tReferences --
_g3.
_tOral insulin delivery -- challenges and strategies --
_g3.1.
_tOral delivery of insulin --
_g3.2.
_tBarriers to oral delivery of insulin --
_g3.3.
_tStrategies and alternatives to improve oral insulin delivery --
_g3.4.
_tConclusion --
_g3.5.
_tReferences --
_g4.
_tExperimental techniques involved in the development of oral Insulin carriers --
_g4.1.
_tIntroduction --
_g4.2.
_tPolymeric nanoparticles --
_g4.3.
_tPhysicochemical characterization of nanoparticles --
_g4.4.
_tBiological evaluation --
_g4.5.
_tIn vitro method for assessing drug permeability --
_g4.6.
_tIn vivo study of oral insulin --
_g4.7.
_tBiodistribution studies --
_g4.8.
_tConclusion --
_g4.9.
_tReferences --
_g5.
_tLipids and inorganic nanoparticles in oral insulin delivery --
_g5.1.
_tLipid-based systems for oral delivery of insulin --
_g5.2.
_tLiposomes --
_g5.3.
_tSolid lipid nanoparticles --
_g5.4.
_tNanostructured lipid carriers --
_g5.5.
_tNiosomes --
_g5.6.
_tArchaeosomes --
_g5.7.
_tCubic nanoparticles (cubosomes) --
_g5.8.
_tAquasomes --
_g5.9.
_tInorganic nanoparticles as carriers for oral insulin delivery --
_g5.10.
_tConclusion --
_g5.11.
_tReferences --
_g6.
_tPolymers in oral insulin delivery --
_g6.1.
_tIntroduction --
_g6.2.
_tCharacteristics of an ideal oral insulin carrier --
_g6.3.
_tPolymers in oral insulin delivery --
_g6.4.
_tNatural polymers --
_g6.5.
_tSynthetic polymers --
_g6.6.
_tConclusion --
_g6.7.
_tReferences --
_g7.
_tSummary and future perspectives for oral insulin delivery --
_g7.1.
_tIntroduction --
_g7.2.
_tTechnologies developed for clinical applications of oral insulin delivery --
_g7.3.
_tConclusions and future perspectives --
_g7.4.
_tReferences.
504 _aIncludes bibliographical references and index.
650 0 _aInsulin
_xTherapeutic use
_xAdministration.
650 0 _aDiabetes
_xOral therapy.
650 7 _aHEALTH & FITNESS
_xDiseases
_xGeneral.
_2bisacsh
650 7 _aMEDICAL
_xClinical Medicine.
_2bisacsh
650 7 _aMEDICAL
_xDiseases.
_2bisacsh
650 7 _aMEDICAL
_xEvidence-Based Medicine.
_2bisacsh
650 7 _aMEDICAL
_xInternal Medicine.
_2bisacsh
650 7 _aDiabetes
_xOral therapy.
_2fast
_0(OCoLC)fst00892178
650 7 _aInsulin
_xTherapeutic use
_xAdministration.
_2fast
_0(OCoLC)fst00974518
650 1 2 _aInsulin
_xadministration & dosage.
_0(DNLM)D007328Q000008
650 1 2 _aAdministration, Oral.
_0(DNLM)D000284
650 2 2 _aDrug Delivery Systems.
_0(DNLM)D016503
655 4 _aElectronic books.
655 0 _aElectronic book.
655 7 _aElectronic books.
_2lcgft
700 1 _aSharma, Chandra P.,
_eauthor.
776 0 8 _iPrint version:
_aSharma, C.P.
_tOral delivery of insulin.
_dCambridge : Woodhead, 2014
_z9781907568473
_w(DLC) 2014950424
_w(OCoLC)876802531
830 0 _aWoodhead Publishing series in biomedicine ;
_vno. 41.
_x2050-0289
856 4 0 _3ScienceDirect
_uhttp://www.sciencedirect.com/science/book/9781907568473
999 _c246954
_d246954