000			05714cam a2200565Mi 4500
001			ocn891381891
003			OCoLC
005			20190328114808.0
006			m o d
007			cr cn|||||||||
008			140918t20152015ne a ob 001 0 eng d
040			_aE7B _beng _erda _epn _cE7B _dOCLCO _dUIU _dN$T _dOCLCF _dOCLCQ _dYDXCP _dYDX _dBUF _dMERER _dOCLCO _dOCLCQ _dU3W _dOCLCO _dD6H _dCHVBK _dOCLCO _dAU@ _dOCLCQ _dOCLCO _dOCLCA _dYOU _dOCLCO _dOCLCA
019			_a899273857
020			_a9780444595904 _q(electronic bk.)
020			_a0444595902 _q(electronic bk.)
020			_z9780444595737
020			_z0444595732
035			_a(OCoLC)891381891 _z(OCoLC)899273857
050		4	_aRM301.4 _b.B567 2015eb
060		4	_aQU 55
072		7	_aMED _x071000 _2bisacsh
082	0	4	_a615.7 _223
245	0	0	_aBiophysical characterization of proteins in developing biopharmaceuticals / _h[electronic resource] _cedited by Damian J. Houde, Steven A. Berkowitz.
264		1	_aAmsterdam, Netherlands : _bElsevier, _c2015.
264		4	_c�2015
300			_a1 online resource (427 pages) : _billustrations
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
504			_aIncludes bibliographical references and index at the end of each chapters.
588	0		_aOnline resource; title from PDF title page (ebrary, viewed September 17, 2014).
505	0		_aFront Cover; Biophysical Characterization of Proteins in Developing Biopharmaceuticals; Copyright; Contents; List of Contributors; About the Editors; Preface; List of Abbreviations and Symbols; Chapter 1 -- The Complexity of Protein Structure and the Challenges it Poses in Developing Biopharmaceuticals; 1.1 THE BASICS OF PROTEIN HIGHER-ORDER STRUCTURE (HOS); 1.2 THE SEARCH FOR HOW PROTEINS ATTAIN THEIR CORRECT HOS: THE PROTEIN FOLDING PROBLEM; 1.3 SURPRISES IN THE WORLD OF PROTEIN FOLDING: INTRINSICALLY DISORDERED OR UNSTRUCTURED PROTEINS (AN APPARENT CHALLENGE TO THE ...
505	8		_a1.4 PROTEINS AND THE BIOPHARMACEUTICAL INDUSTRY: PROBLEMS AND CHALLENGES1.5 CONCLUSION; References; Further Reading; Chapter 2 -- Biophysical Characterization and Its Role in the Biopharmaceutical Industry; 2.1 DRUG DEVELOPMENT PROCESS; 2.2 PROTEIN DRUGS (BIOPHARMACEUTICALS); 2.3 THE ROLE OF BIOPHYSICAL CHARACTERIZATION IN BIOPHARMACEUTICAL DRUG DEVELOPMENT; 2.4 THE CHALLENGES IN CONDUCTING BIOPHYSICAL MEASUREMENTS TO DETECT CHANGES IN A PROTEIN DRUG''S HOS; 2.5 REGULATORY NEEDS AND CONSIDERATIONS; References; Further Reading; Chapter 3 -- Biopharmaceutical Industry''s Biophysical Toolbox.
505	8		_a3.1 ATTRIBUTES OF A SINGLE BIOPHYSICAL TOOL TO CHARACTERIZE AND DETECT CHANGES IN THE HIGHER ORDER STRUCTURE OF A BIOPHARMACEUTICAL3.2 STUDYING THE BIOPHYSICAL PROPERTIES OF A BIOPHARMACEUTICAL AS AN INDIRECT APPROACH FOR CHARACTERIZING CHANGES IN ITS HOS; 3.3 GENERAL CONSIDERATIONS IN ANALYZING THE BIOPHYSICAL PROPERTIES OF BIOPHARMACEUTICALS; 3.4 THE UTILITY OF USING STRESS TO MONITOR CHANGES IN THE HOS PROFILE OF A PROTEIN DRUG; 3.5 PRESENT BIOPHYSICAL TOOLBOX; 3.6 CONCLUSION; References; Further Reading.
505	8		_aChapter 4 -- An Introduction and Hierarchical Organization of the Biophysical Tool in Section II4.1 INTRODUCTION; 4.2 THE STANDARD CLASS OF BIOPHYSICAL TOOLS USED IN THE BIOPHARMACEUTICAL INDUSTRY; 4.3 THE ADVANCED CLASS OF BIOPHYSICAL TOOLS USED IN THE BIOPHARMACEUTICAL INDUSTRY; 4.4 AN OVERVIEW OF SECTION II; References; Further Reading; Chapter 5 -- The Value of UV, Fluorescence, and FTIR Spectroscopy in Biopharmaceutical Development; 5.1 INTRODUCTION; 5.2 THE ORIGINS OF ELECTRONIC ABSORPTION, FLUORESCENCE, AND FT-IR SPECTROSCOPY; 5.3 CONFORMATIONAL ANALYSIS OF PROTEINS IN SOLUTION.
505	8		_a5.4 OPTICAL SPECTROSCOPY AND PRODUCT COMPARABILITY5.5 OPTICAL SPECTROSCOPY AND HIGH-THROUGHPUT METHODS; 5.6 SOLID-STATE MEASUREMENTS; 5.7 CONCLUSIONS; References; Chapter 6 -- Circular Dichroism Spectroscopy for Protein Characterization: Biopharmaceutical Applications; 6.1 INTRODUCTION; 6.2 INSTRUMENTATION; 6.3 DATA GENERATED; 6.4 GUIDE TO COLLECTING GOOD DATA; 6.5 DATA PROCESSING AND ANALYSES; 6.6 ROLE IN THE RESEARCH INDUSTRY; 6.7 TECHNOLOGY AVAILABILITY; 6.8 FUTURE DEVELOPMENTS; Acknowledgments; References; Further Reading.
505	8		_aChapter 7 -- Size-Exclusion Chromatograph (SEC) in Biopharmaceutical Process Development.
520			_aBiophysical Characterization of Proteins in Developing Biopharmaceuticals is concerned with the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure this book takes the reader on a journey on how to best achieve this goal using the key relevant and practical methods commonly employed in the biopharmaceutical industry today as well as up and coming promising methods that are now gaining increasing attention. As a general resource guide this book has been written with the intent to help tod.
650		0	_aBiopharmaceutics.
650		7	_aMEDICAL _xPharmacology. _2bisacsh
650		7	_aBiopharmaceutics. _2fast _0(OCoLC)fst00832650
650		2	_aProteins _xanalysis. _0(DNLM)D011506Q000032
650		2	_aBiopharmaceutics. _0(DNLM)D001702
650		2	_aTechnology, Pharmaceutical. _0(DNLM)D013678
655		4	_aElectronic books.
700	1		_aHoude, Damian J., _eeditor.
700	1		_aBerkowitz, Steven A., _eeditor.
776	0	8	_iPrint version: _tBiophysical characterization of proteins in developing biopharmaceuticals. _dAmsterdam, Netherlands : Elsevier, �2015 _hxxi, 404 pages _z9780444595737
856	4	0	_3ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780444595737
999			_c246962 _d246962