000 06360cam a2200769Ii 4500
001 ocn893332893
003 OCoLC
005 20190328114809.0
006 m o d
007 cr cnu---unuuu
008 141018s2015 enka ob 001 0 eng d
040 _aEBLCP
_beng
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020 _a9780123984906
_q(electronic bk.)
020 _a0123984904
_q(electronic bk.)
020 _a0123979331
020 _a9780123979339
020 _z9780123979339
035 _a(OCoLC)893332893
050 4 _aQR185.6
060 4 _aOnline Book
072 7 _aHEA
_x039000
_2bisacsh
072 7 _aMED
_x014000
_2bisacsh
072 7 _aMED
_x022000
_2bisacsh
072 7 _aMED
_x112000
_2bisacsh
072 7 _aMED
_x045000
_2bisacsh
082 0 4 _a616.07
_a616.0798
245 0 0 _aMolecular biology of B cells /
_h[electronic resource]
_cedited by Frederick W. Alt, Tasuku Honjo, Andreas Radbruch, Michael Reth.
250 _a2nd ed.
264 1 _aLondon :
_bElsevier Science,
_c2015.
300 _a1 online resource (xxiii 563 pages) :
_bcolor illustrations
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
504 _aIncludes bibliographical references and index.
588 0 _aOnline resource; title from PDF title page (ScienceDirect, viewed on November 6, 2014).
520 _aMolecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with update.
505 0 _aFront Cover; Molecular Biology of B Cells; Copyright; Dedication; Contents; Preface; Contributors; Chapter 1 -- The Structure and Regulation of the Immunoglobulin Loci; 1. INTRODUCTION; 2. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN HEAVY CHAIN LOCUS; 3. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN KAPPA LIGHT CHAIN LOCUS; 4. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN LAMBDA LIGHT CHAIN LOCUS; 5. B CELL DEVELOPMENT AND REGULATION OF V(D)J RECOMBINATION; 6. JUNCTIONAL DIVERSITY; 7. COMBINATORIAL DIVERSITY; 8. NONCODING TRANSCRIPTION AND IMMUNOGLOBULIN LOCUS REARRANGEMENT.
505 8 _a9. THE PROCESS OF DH-JH RECOMBINATION10. EPIGENETICS AND IMMUNOGLOBULIN LOCUS REARRANGEMENT; 11. INSULATORS AND IMMUNOGLOBULIN LOCUS REARRANGEMENT; 12. 3D STRUCTURE AND COMPACTION OF THE IMMUNOGLOBULIN HEAVY CHAIN LOCUS; 13. CONCLUSION; REFERENCES; Chapter 2 -- The Mechanism of V(D)J Recombination; 1. OVERVIEW; 2. ANTIGEN RECEPTOR GENE ASSEMBLY; 3. RECOMBINATION SIGNAL SEQUENCES; 4. BIOCHEMISTRY OF V(D)J CLEAVAGE; 5. RAG1 AND RAG2; 6. A ROLE FOR HMGB1 IN V(D)J RECOMBINATION; 7. RECOMBINATION COMPLEXES: ANALYSIS OF STOICHIOMETRY AND ORGANIZATION.
505 8 _a8. V(D)J RECOMBINATION IS TIGHTLY REGULATED DURING LYMPHOCYTE DEVELOPMENT9. ACCESSIBILITY MODEL OF REGULATION; 10. OVERVIEW OF CHROMATIN STRUCTURE; 11. REGULATION BY NUCLEOSOME STRUCTURE AND HISTONE ACETYLATION; 12. REGULATION BY HISTONE METHYLATION; 13. HOW IS THE CHROMATIN STRUCTURE OF ANTIGEN RECEPTOR LOCI DEVELOPMENTALLY REGULATED?; 14. ADDITIONAL LAYERS OF REGULATION; 15. REGULATION OF V(D)J RECOMBINATION: SUMMARY; 16. ONCOGENIC LESIONS IN LYMPHOID NEOPLASMS: THE PRICE OF A DIVERSE ANTIGEN RECEPTOR REPERTOIRE; 17. PROPOSED MECHANISMS UNDERLYING RAG-MEDIATED GENOMIC LESIONS.
505 8 _a18. REGULATORY CONTROLS PROPOSED TO SUPPRESS RAG-MEDIATED GENOMIC INSTABILITY19. V(D)J RECOMBINATION ERRORS AS PATHOGENIC LESIONS IN LYMPHOID NEOPLASMS: SUMMARY; REFERENCES; Chapter 3 -- Transcriptional Regulation of Early B Cell Development; 1. PU. 1 SETS THE STAGE FOR LYMPHOID AND MYELOID DEVELOPMENT; 2. LINEAGE PRIMING IN LYMPHOID PROGENITORS BY IKAROS; 3. E2A REGULATES THE CHROMATIN LANDSCAPE TO PROMOTE GENE EXPRESSION IN B CELL DEVELOPMENT; 4. E2A IS INHIBITED BY ID PROTEINS; 5. INTERLEUKIN-7/STAT5 SIGNALING PROVIDES AN EARLY SIGNAL FOR B CELL LINEAGE SPECIFICATION.
505 8 _a6. EARLY B CELL FACTOR: CENTRAL COORDINATOR OF B CELL DEVELOPMENT7. COLLABORATION BETWEEN EBF1 AND FOXO1; 8. REGULATION OF THE B CELL-SPECIFIC PROGRAM BY PAX5; 9. REGULATION OF B LINEAGE COMMITMENT; 10. CONCLUSION; ACKNOWLEDGMENT; REFERENCES; Chapter 4 -- Relationships among B Cell Populations Revealed by Global Gene Analysis; 1. INTRODUCTION; 2. GENE PROFILE CHANGES WITH B CELL MATURATION SUGGEST AN ORDERING OF TRANSITIONAL STAGES; 3. DISTINCTIONS IN GENE NETWORKS ACTIVATED IN MATURE B CELL POPULATIONS.
650 0 _aMolecular immunology.
650 0 _aB cells.
650 0 _aB cells
_xDifferentiation
_xMolecular aspects.
650 0 _aImmunoglobulins.
650 0 _aImmunoglobulin genes.
650 1 2 _aB-Lymphocytes.
650 1 2 _aImmunoglobulins.
650 2 2 _aCell Differentiation
_xphysiology.
650 7 _aHEALTH & FITNESS
_xDiseases
_xGeneral.
_2bisacsh
650 7 _aMEDICAL
_xClinical Medicine.
_2bisacsh
650 7 _aMEDICAL
_xDiseases.
_2bisacsh
650 7 _aMEDICAL
_xEvidence-Based Medicine.
_2bisacsh
650 7 _aMEDICAL
_xInternal Medicine.
_2bisacsh
650 7 _aB cells.
_2fast
_0(OCoLC)fst00824789
650 7 _aB cells
_xDifferentiation
_xMolecular aspects.
_2fast
_0(OCoLC)fst00824791
650 7 _aImmunoglobulin genes.
_2fast
_0(OCoLC)fst00967959
650 7 _aImmunoglobulins.
_2fast
_0(OCoLC)fst00967961
650 7 _aMolecular immunology.
_2fast
_0(OCoLC)fst01024811
655 4 _aElectronic books.
700 1 _aHonj�o, Tasuku,
_eeditor.
700 1 _aReth, Michael,
_eeditor.
700 1 _aRadbruch, A.
_q(Andreas),
_eeditor.
700 1 _aAlt, Frederick W.,
_eeditor.
776 0 8 _iPrint version:
_tMolecular biology of B cells.
_dBoston, Massachusetts : Elsevier, [2015]
_z9780123979339
856 4 0 _3ScienceDirect
_uhttp://www.sciencedirect.com/science/book/9780123979339
999 _c246969
_d246969