000 06111cam a2200469Ii 4500
001 ocn899739223
003 OCoLC
005 20190328114810.0
006 m o d
007 cr cnu|||unuuu
008 150109s2015 ne a ob 001 0 eng d
040 _aN$T
_beng
_erda
_epn
_cN$T
_dN$T
_dOPELS
_dYDXCP
_dD6H
_dU3W
_dOCL
020 _a9780128010532
_qelectronic bk.
020 _a0128010533
_qelectronic bk.
020 _z9780128010327
020 _z0128010320
035 _a(OCoLC)899739223
050 4 _aQH603.L9
_bA883 2014
072 7 _aSCI
_x056000
_2bisacsh
082 0 4 _a571.9/36
_223
245 0 0 _aAutophagy : cancer, other pathologies, inflammation, immunity, infection, and aging : Vol. 6 /
_h[electronic resource]
_cedited by M.A. Hayat.
264 1 _aAmsterdam :
_bElsevier,
_c2015
264 4 _c�2015
300 _a1 online resource :
_bcolor illustrations
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
504 _aIncludes bibliographical references and indexes.
520 _aVolume 6 provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Attention is given to a number of mechanistic advances in the understanding of regulation, particularly the importance of nutrient availability; microRNAs; and cross-talk with other protein degradation pathways. Intracellular pathogen repurposing of autophagy for pathogenic benefit is also provided, with coverage of Herpesvirus protein modulation of autophagy; the varicella-zoster virus and the maintenance of homeostasis; and the relationship between autophagy and the hepatitis b virus. The significance of autophagy in host defense is elucidated, providing a specific focus on facilitation of antigen presentation; participation in thymic development; and the sharing of regulatory nodes with innate immunity. Selective autophagy for the degradation of mitochondria and endocytosed gap junctions are also explored. This book is an asset to newcomers as a concise overview of the regulation of autophagy, its role in host defense and immunity, and selective autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy's association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy's effects in various cardiovascular, metabolic, and neurodegenerative disorders. Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation. Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes.
650 0 _aAutophagic vacuoles.
650 0 _aCell death.
650 0 _aNatural immunity.
650 0 _aLysosomes
_xPhysiology.
650 7 _aSCIENCE / Life Sciences / Anatomy & Physiology
_2bisacsh
650 7 _aNatural immunity.
_2fast
_0(OCoLC)fst01034361
650 7 _aCell death.
_2fast
_0(OCoLC)fst00850180
650 7 _aAutophagic vacuoles.
_2fast
_0(OCoLC)fst00824188
655 4 _aElectronic books.
700 1 _aHayat, M. A.,
_d1940-
_eeditor.
776 0 8 _iPrint version:
_tAutophagy. Cancer, other pathologies, inflammation, immunity, infection, and aging. Volume 6.
_dLondon, England : Academic Press, �2015
_hxxxiii, 294 pages
_z9780128010327
856 4 0 _3ScienceDirect
_uhttp://www.sciencedirect.com/science/book/9780128010327
999 _c247037
_d247037