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019 _a918932218
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_a929142275
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020 _a9780127999203
_q(electronic bk.)
020 _a0127999205
_q(electronic bk.)
020 _z9780124201941
020 _z0124201946
035 _a(OCoLC)918892654
_z(OCoLC)918932218
_z(OCoLC)918994293
_z(OCoLC)923544167
_z(OCoLC)929142275
_z(OCoLC)1066460860
050 4 _aQP624.5.M46
060 4 _aQU 58.5
072 7 _aSCI
_x007000
_2bisacsh
082 0 4 _a572.8/645
_223
100 1 _aNeidhart, Michel,
_eauthor.
245 1 0 _aDNA methylation and complex human disease /
_h[electronic resource]
_cMichel Neidhart.
264 1 _aAmsterdam :
_bElsevier,
_c2016.
300 _a1 online resource
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
588 0 _aOnline resource; title from PDF title page (EBSCO, viewed August 20, 2015).
504 _aIncludes bibliographical references and index.
505 0 _a""Front Cover""; ""DNA Methylation and Complex Human Disease""; ""Copyright Page""; ""Contents""; ""Preface""; ""About the Author""; ""1 DNA Methylation �a�? Introduction""; ""1.1 Epigenetics""; ""1.2 Histone Modifications""; ""1.2.1 Histone Acetylation and Deacetylation""; ""1.2.2 Histone Methylation""; ""1.3 DNA Methylation""; ""1.3.1 DNA Methyltransferases""; ""1.4 Methyl-Binding Domain Proteins""; ""1.5 DNA Demethylation""; ""1.6 DNA Hydroxymethylation""; ""1.7 Differentially Methylated Regions""; ""1.8 Nutriepigenomics""; ""References""
505 8 _a""2 DNA Methylation and Epigenetic Biomarkers in Cancer""""2.1 Introduction""; ""2.1.1 Diagnosis Biomarkers""; ""2.1.2 Progression Biomarkers""; ""2.1.3 Predictive Biomarkers""; ""2.1.4 Discovery of Novel Biomarkers""; ""2.2 Cancerogenesis""; ""2.3 Epimutations in Cancer""; ""2.3.1 Esophageal Adenocarcinoma""; ""2.3.2 Gastric Cancer""; ""2.3.3 Colorectal Carcinoma""; ""2.3.4 Lynch Syndrome""; ""2.3.5 Endometrial and Ovarian Cancers""; ""2.3.6 Lung Cancer""; ""2.3.7 Glioblastoma""; ""2.3.8 Hematopoietic Cancers""; ""2.4 Conclusion""; ""References""
505 8 _a""3 DNA Methylation and Epigenetic Biomarkers in Non-Neoplastic Diseases""""3.1 Introduction""; ""3.2 Autoimmunity""; ""3.2.1 Type 1 Diabetes""; ""3.2.2 Rheumatoid Arthritis""; ""3.2.3 Systemic Lupus Erythematosis""; ""3.2.4 Inflammatory Bowel Disease, Crohn�a�?s Disease, and Ulcerative Colitis""; ""3.3 Metabolic Diseases""; ""3.3.1 Type 2 Diabetes""; ""3.3.2 Heart Failure""; ""3.4 Developmental Diseases""; ""3.4.1 Imprinting Disorders""; ""3.4.2 Arrhythmia""; ""3.5 Psychiatric Diseases""; ""3.5.1 Major Depressive Disorder""; ""3.5.2 Schizophrenia""; ""3.6 Conclusion""; ""References""
505 8 _a""4 DNA Methylation and Environmental Factors""""4.1 Introduction""; ""4.2 Impact of the Environment in Early Life""; ""4.2.1 Genomic Imprinting""; ""4.2.2 Beckwith-Wiedemann Syndrome""; ""4.2.3 Assisted Reproductive Technologies""; ""4.2.4 Large Offspring Syndrome""; ""4.3 Nutritional Factors""; ""4.3.1 Gestational Maternal Nutritional Factors""; ""4.3.2 Nutritional Deficiencies""; ""4.4 Adverse Environmental Factors""; ""4.4.1 Environmental Toxicants""; ""4.4.2 Ethanol Consumption""; ""4.4.3 Smoking""; ""4.5 Immune Activation""; ""4.5.1 Asthma and Allergy""; ""4.5.2 Bacterial Infections""
505 8 _a""4.5.3 Viral Infections""""4.6 Maternal Mood and Experience in Early Life""; ""4.7 Physical Exercise""; ""4.8 Conclusion""; ""References""; ""5 DNA Methylation and Epidemiology""; ""5.1 Introduction""; ""5.2 Endocrine Disrupting Chemicals""; ""5.2.1 Bisphenol-A""; ""5.2.2 Diethylstillbestrol""; ""5.2.3 Cadmium""; ""5.3 Epigenomics and Breast Cancer""; ""5.3.1 RASSF1A""; ""5.3.2 P16/CDKN2A""; ""5.4 Tobacco Smoking""; ""5.4.1 F2RL3, Smoking, and Cardiovascular Diseases""; ""5.4.2 RUNX3, Smoking, Low Birth Weight, and Lung Carcinomas""; ""5.4.3 AHRR, Smoking, and Lung Metastasis""
520 _aDNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylati.
650 0 _aDNA
_xMethylation.
650 0 _aMedical genetics.
650 7 _aSCIENCE
_xLife Sciences
_xBiochemistry.
_2bisacsh
650 7 _aDNA
_xMethylation.
_2fast
_0(OCoLC)fst00886570
650 7 _aMedical genetics.
_2fast
_0(OCoLC)fst01014133
650 2 _aDNA Methylation.
_0(DNLM)D019175
650 2 _aGenetics, Medical.
_0(DNLM)D005826
655 4 _aElectronic books.
655 0 _aElectronic book.
776 0 8 _iPrint version:
_aNeidhart, Michel.
_tDNA methylation and complex human disease.
_dAmsterdam : Elsevier, 2016
_z9780124201941
_z0124201946
_w(OCoLC)885228983
856 4 0 _3ScienceDirect
_uhttp://www.sciencedirect.com/science/book/9780124201941
999 _c247136
_d247136