000 | 05693cam a2200577Ii 4500 | ||
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001 | ocn918892654 | ||
003 | OCoLC | ||
005 | 20190328114812.0 | ||
006 | m o d | ||
007 | cr cnu|||unuuu | ||
008 | 150818s2016 cau ob 001 0 eng d | ||
040 |
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_a016938658 _2Uk |
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019 |
_a918932218 _a918994293 _a923544167 _a929142275 _a1066460860 |
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020 |
_a9780127999203 _q(electronic bk.) |
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020 |
_a0127999205 _q(electronic bk.) |
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020 | _z9780124201941 | ||
020 | _z0124201946 | ||
035 |
_a(OCoLC)918892654 _z(OCoLC)918932218 _z(OCoLC)918994293 _z(OCoLC)923544167 _z(OCoLC)929142275 _z(OCoLC)1066460860 |
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050 | 4 | _aQP624.5.M46 | |
060 | 4 | _aQU 58.5 | |
072 | 7 |
_aSCI _x007000 _2bisacsh |
|
082 | 0 | 4 |
_a572.8/645 _223 |
100 | 1 |
_aNeidhart, Michel, _eauthor. |
|
245 | 1 | 0 |
_aDNA methylation and complex human disease / _h[electronic resource] _cMichel Neidhart. |
264 | 1 |
_aAmsterdam : _bElsevier, _c2016. |
|
300 | _a1 online resource | ||
336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
||
588 | 0 | _aOnline resource; title from PDF title page (EBSCO, viewed August 20, 2015). | |
504 | _aIncludes bibliographical references and index. | ||
505 | 0 | _a""Front Cover""; ""DNA Methylation and Complex Human Disease""; ""Copyright Page""; ""Contents""; ""Preface""; ""About the Author""; ""1 DNA Methylation �a�? Introduction""; ""1.1 Epigenetics""; ""1.2 Histone Modifications""; ""1.2.1 Histone Acetylation and Deacetylation""; ""1.2.2 Histone Methylation""; ""1.3 DNA Methylation""; ""1.3.1 DNA Methyltransferases""; ""1.4 Methyl-Binding Domain Proteins""; ""1.5 DNA Demethylation""; ""1.6 DNA Hydroxymethylation""; ""1.7 Differentially Methylated Regions""; ""1.8 Nutriepigenomics""; ""References"" | |
505 | 8 | _a""2 DNA Methylation and Epigenetic Biomarkers in Cancer""""2.1 Introduction""; ""2.1.1 Diagnosis Biomarkers""; ""2.1.2 Progression Biomarkers""; ""2.1.3 Predictive Biomarkers""; ""2.1.4 Discovery of Novel Biomarkers""; ""2.2 Cancerogenesis""; ""2.3 Epimutations in Cancer""; ""2.3.1 Esophageal Adenocarcinoma""; ""2.3.2 Gastric Cancer""; ""2.3.3 Colorectal Carcinoma""; ""2.3.4 Lynch Syndrome""; ""2.3.5 Endometrial and Ovarian Cancers""; ""2.3.6 Lung Cancer""; ""2.3.7 Glioblastoma""; ""2.3.8 Hematopoietic Cancers""; ""2.4 Conclusion""; ""References"" | |
505 | 8 | _a""3 DNA Methylation and Epigenetic Biomarkers in Non-Neoplastic Diseases""""3.1 Introduction""; ""3.2 Autoimmunity""; ""3.2.1 Type 1 Diabetes""; ""3.2.2 Rheumatoid Arthritis""; ""3.2.3 Systemic Lupus Erythematosis""; ""3.2.4 Inflammatory Bowel Disease, Crohn�a�?s Disease, and Ulcerative Colitis""; ""3.3 Metabolic Diseases""; ""3.3.1 Type 2 Diabetes""; ""3.3.2 Heart Failure""; ""3.4 Developmental Diseases""; ""3.4.1 Imprinting Disorders""; ""3.4.2 Arrhythmia""; ""3.5 Psychiatric Diseases""; ""3.5.1 Major Depressive Disorder""; ""3.5.2 Schizophrenia""; ""3.6 Conclusion""; ""References"" | |
505 | 8 | _a""4 DNA Methylation and Environmental Factors""""4.1 Introduction""; ""4.2 Impact of the Environment in Early Life""; ""4.2.1 Genomic Imprinting""; ""4.2.2 Beckwith-Wiedemann Syndrome""; ""4.2.3 Assisted Reproductive Technologies""; ""4.2.4 Large Offspring Syndrome""; ""4.3 Nutritional Factors""; ""4.3.1 Gestational Maternal Nutritional Factors""; ""4.3.2 Nutritional Deficiencies""; ""4.4 Adverse Environmental Factors""; ""4.4.1 Environmental Toxicants""; ""4.4.2 Ethanol Consumption""; ""4.4.3 Smoking""; ""4.5 Immune Activation""; ""4.5.1 Asthma and Allergy""; ""4.5.2 Bacterial Infections"" | |
505 | 8 | _a""4.5.3 Viral Infections""""4.6 Maternal Mood and Experience in Early Life""; ""4.7 Physical Exercise""; ""4.8 Conclusion""; ""References""; ""5 DNA Methylation and Epidemiology""; ""5.1 Introduction""; ""5.2 Endocrine Disrupting Chemicals""; ""5.2.1 Bisphenol-A""; ""5.2.2 Diethylstillbestrol""; ""5.2.3 Cadmium""; ""5.3 Epigenomics and Breast Cancer""; ""5.3.1 RASSF1A""; ""5.3.2 P16/CDKN2A""; ""5.4 Tobacco Smoking""; ""5.4.1 F2RL3, Smoking, and Cardiovascular Diseases""; ""5.4.2 RUNX3, Smoking, Low Birth Weight, and Lung Carcinomas""; ""5.4.3 AHRR, Smoking, and Lung Metastasis"" | |
520 | _aDNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylati. | ||
650 | 0 |
_aDNA _xMethylation. |
|
650 | 0 | _aMedical genetics. | |
650 | 7 |
_aSCIENCE _xLife Sciences _xBiochemistry. _2bisacsh |
|
650 | 7 |
_aDNA _xMethylation. _2fast _0(OCoLC)fst00886570 |
|
650 | 7 |
_aMedical genetics. _2fast _0(OCoLC)fst01014133 |
|
650 | 2 |
_aDNA Methylation. _0(DNLM)D019175 |
|
650 | 2 |
_aGenetics, Medical. _0(DNLM)D005826 |
|
655 | 4 | _aElectronic books. | |
655 | 0 | _aElectronic book. | |
776 | 0 | 8 |
_iPrint version: _aNeidhart, Michel. _tDNA methylation and complex human disease. _dAmsterdam : Elsevier, 2016 _z9780124201941 _z0124201946 _w(OCoLC)885228983 |
856 | 4 | 0 |
_3ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780124201941 |
999 |
_c247136 _d247136 |