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016 7 _a101671936
_2DNLM
019 _a923546172
_a929142666
_a937530114
_a1066627783
020 _a9780124116207
_q(electronic bk.)
020 _a0124116205
_q(electronic bk.)
020 _a0124115969
020 _a9780124115965
020 _z9780124115965
020 _z0124115969
024 3 _a9780124116207
024 3 _a9780124115965
035 _a(OCoLC)919087033
_z(OCoLC)923546172
_z(OCoLC)929142666
_z(OCoLC)937530114
_z(OCoLC)1066627783
050 4 _aQP86
060 0 0 _aWT 104
_bH236 2016
072 7 _aSCI
_x056000
_2bisacsh
082 0 4 _a571.8/78
_223
245 0 0 _aHandbook of the biology of aging /
_h[electronic resource]
_cedited by Matt R. Kaeberlein and George M. Martin.
250 _a8th ed.
264 1 _aAmsterdam :
_bElsevier Ltd.,
_c2016.
264 4 _c�2016
300 _a1 online resource (xvi, 559 pages) :
_billustrations.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aHandbooks of aging ;
_vvolume 3
504 _aIncludes bibliographical references and indexes.
588 0 _aOnline resource; title from PDF title page (EBSCO, viewed August 26, 2015).
505 0 _a""Front Cover""; ""Handbook of the Biology of Aging""; ""Copyright Page""; ""Contents""; ""Foreword""; ""Preface""; ""About the Editors""; ""List of Contributors""; ""I. Basic Mechanisms of Aging: Models and Systems""; ""1 Longevity as a Complex Genetic Trait""; ""Introduction""; ""Defining the Aging Gene-Space""; ""Direct Screens for Genetic Longevity Determinants""; ""RNAi Screens in Nematodes""; ""Knockout Screens in Budding Yeast""; ""Overexpression Screens in Fruit Flies""; ""Leveraging Genetic Diversity to Identify Aging Loci""; ""Mapping Longevity Genes in Human Populations""
505 8 _a""Mapping Longevity Genes in Mouse Populations""""Mouse�a�?Human Concordance""; ""Age-Associated Gene Expression Studies""; ""Non-Genetic Sources of Complexity""; ""Tissue-Specific Aging""; ""Tissue-Specific Age-Related DNA Methylation""; ""Telomere Shortening and Telomerase""; ""Tissue-Specific Responses of Aging Pathways""; ""Gene�a�?Environment Interaction""; ""Genetic Response to DR""; ""DR: Quantity, Composition, and Timing""; ""Environmental Temperature""; ""Environmental Oxygen and the Hypoxic Response""; ""Other Environmental Factors That Influence Aging""
505 8 _a""Emerging Tools for Studying Aging as a Complex Genetic Trait""""High-Throughput Lifespan Assays in Yeast and Worms""; ""Genome-Scale Mouse Knockout Collection""; ""Collaborative Cross and Diversity Outbred Mice""; ""Expression QTLs""; ""Aging Biomarkers""; ""Conclusions""; ""References""; ""2 The mTOR Pathway and Aging""; ""Introduction""; ""mTOR Signaling Pathway""; ""Molecular Composition of mTOR Complex""; ""Upstream Regulators of mTOR Complexes""; ""Substrates and Actions of mTORC1""; ""Substrates and Actions of mTORC2""
505 8 _a""Genetic Modulation of Longevity by TOR Signaling in Model Organisms""""Rapamycin""; ""Rapalogs""; ""Potential Mechanisms of Life Span Extension by mTOR Inhibition""; ""Translation""; ""Autophagy""; ""Anticancer Effect""; ""Stem Cell Maintenance""; ""mTOR in Age-Related Diseases""; ""Cancer""; ""Metabolic Disease""; ""Cardiovascular""; ""Neurodegeneration and Cognitive Decline""; ""Immune Response""; ""Conclusion""; ""References""; ""3 Sirtuins, Healthspan, and Longevity in Mammals""; ""Introduction""; ""Sirtuin-Driven Lifespan Extension in Invertebrates""; ""Sirtuin Enzymatic Activity""
505 8 _a""Sirtuins and Mammalian Longevity""""SIRT1""; ""SIRT2""; ""SIRT6""; ""Genetic Variation of Human Sirtuins""; ""SIRT1""; ""SIRT3""; ""Sirtuins as Modulators of Responses to CR""; ""SIRT1""; ""SIRT2""; ""SIRT3""; ""SIRT4""; ""SIRT5""; ""SIRT6""; ""Roles for Sirtuins in Diverse Disease States""; ""Cancer""; ""SIRT1""; ""SIRT2""; ""SIRT3""; ""SIRT4""; ""SIRT6""; ""SIRT7""; ""Metabolic Syndrome""; ""SIRT1""; ""SIRT2""; ""SIRT3""; ""SIRT4""; ""SIRT5""; ""SIRT6""; ""SIRT7""; ""Cardiovascular Dysfunction""; ""SIRT1""; ""Other Sirtuins""; ""Inflammatory Signaling""; ""Neurodegenerative Disease""
520 _aHandbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussion.
504 _aIncludes bibliographical references and index.
650 0 _aAging
_xPhysiological aspects.
650 2 _aAging
_xphysiology.
_0(DNLM)D000375Q000502
650 7 _aSCIENCE
_xLife Sciences
_xAnatomy & Physiology.
_2bisacsh
650 7 _aAging
_xPhysiological aspects.
_2fast
_0(OCoLC)fst00800323
655 4 _aElectronic books.
655 0 _aElectronic book.
700 1 _aKaeberlein, Matt,
_d1971-
_eeditor.
700 1 _aMartin, George M.,
_d1927-
_eeditior.
776 0 8 _iPrint version:
_aKaeberlein, Matt.
_tHandbook of the Biology of Aging.
_d: Elsevier Science, �2015
_z9780124115965
830 0 _aHandbooks of aging ;
_vv. 3.
856 4 0 _3ScienceDirect
_uhttp://www.sciencedirect.com/science/book/9780124115965
999 _c247142
_d247142