000			05307cam a2200613Ma 4500
001			ocn925286798
003			OCoLC
005			20190328114813.0
006			m o d
007			cr |n|||||||||
008			151016t20152016enk ob 001 0 eng d
040			_aIDEBK _beng _epn _cIDEBK _dN$T _dOPELS _dN$T _dYDXCP _dOCLCF _dEBLCP _dCDX _dOCLCQ _dYDX _dOCLCQ _dIDB _dOCLCQ _dMERUC _dCOO _dITD _dOCLCO _dOCLCQ _dU3W _dOCLCO _dD6H _dCHVBK _dOCLCO _dAU@ _dOCLCO _dUKMGB _dOCLCQ _dOCLCO _dOCLCA _dCUY _dZCU _dOCLCO _dICG _dUSU _dOCLCO _dDKC _dOCLCO
016	7		_a017595343 _2Uk
019			_a929530023 _a932052201 _a934623063 _a957680020 _a958083503
020			_a0128004967 _q(electronic bk.)
020			_a9780128004968 _q(electronic bk.)
020			_a0128001402
020			_a9780128001400
020			_z9780128001400
020			_z0128001402
024	3		_a9780128001400
035			_a(OCoLC)925286798 _z(OCoLC)929530023 _z(OCoLC)932052201 _z(OCoLC)934623063 _z(OCoLC)957680020 _z(OCoLC)958083503
050		4	_aQH450
060		4	_aQU 460
072		7	_aSCI _x027000 _2bisacsh
082	0	4	_a576.5 _223
245	0	0	_aEpigenomics in health and disease / _h[electronic resource] _cedited by Mario F. Fraga and Agustin F. Fernandez.
260			_aLondon : _bAcademic Press, _c2015, �2016.
300			_a1 online resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aTranslational epigenetics series
500			_aIncludes index.
588	0		_aPrint version record.
504			_aIncludes bibliographical references at the end of each chapters and index.
505	0	0	_tThe role of the genetic code in the DNA methylation landscape formation / _rHolger Heyn -- _tDNA methylation microarrays / _rMarina Bibikova -- _tUltra-deep sequencing of bisulfite-modified DNA / _rTingting Qin, Yongseok Park, Maria E. Figueroa and Maureen A. Sartor -- _tBioinformatics tools in epigenomics studies / _rGustavo F. Bay�on, August�in F. Fern�andez and Mario F. Fraga -- _tNoncoding RNA regulation of health and disease / _rNicolas L�eveill�e, Carlos A. Melo and Sonia A. Melo -- _tGenome-wide DNA methylation changes during aging / _rKevin C. Johnson and Brock C. Christensen -- _tThe dynamics of histone modifications during aging / _rAnthony J Bainor and Gregory David -- _tEpigenomic studies in epidemiology / _rValentina Bollati, Valeria Motta, Simona Iodice and Michele Carugno -- _tThe DNA methylomes of cancer / _rRen�ee Beekman, Marta Kulis and Jos�e Ignacio Mart�in-Subero -- _tGenome-wide epigenetic studies in neurologic diseases / _rAshwin Woodhoo -- _tEpigenetic deregulation in autoimmune disease / _rDamiana �Alvarez-Errico and Esteban Ballestar -- _tGenome-wide DNA and histone modification studies in metabolic disease / _rCharlotte Ling and Tina R�onn -- _tClinical applications of epigenomics / _rMichael A. McDevitt.
520			_aReviews the technologically-driven study of the oganismal epigenome and associated translational impacts on future prognosis, diagnosis and therapies of disease. With next-generation sequencing technologies shaping our current knowledge of the role of epigenetics in normal development, aging, and disease, Epigenomics in Health and Disease discusses the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. Chapters also explore the latest findings of epigenome-wade research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories. With coverage pertinent both to basic biology and translational research, Epigenomics in Health and Disease will be of particular interest for medical and bioscience researches and students seeking current translational knowledge in epigenesis and epigenomics. Key Features Critical reviews provide the means for reviewing and analyzing the epigenome as a whole as well as its translational potential Combines basic epigenomic knowledge with methodological and biostatistical topics related to technology and date analysis Includes coverage of relatively new topics including DNA methylation dynamics during development and differentiation, genome-wide histone post-translational modifications during development and differentiation, and genome-wide DNA methylation changes during aging.
650		0	_aEpigenetics.
650		0	_aMedical genetics.
650		7	_aSCIENCE _xLife Sciences _xEvolution. _2bisacsh
650		7	_aEpigenetics. _2fast _0(OCoLC)fst01893642
650		7	_aMedical genetics. _2fast _0(OCoLC)fst01014133
650		2	_aEpigenomics _xmethods. _0(DNLM)D057890Q000379
650		2	_aEpigenesis, Genetic. _0(DNLM)D044127
650		2	_aGene Expression Regulation. _0(DNLM)D005786
655		7	_aElectronic books. _2lcgft
655		4	_aElectronic books.
700	1		_aFraga, Mario.
700	1		_aFernandez, Agustin F.
776	0	8	_iPrint version: _aFraga, Mario. _tEpigenomics in Health and Disease. _d: Elsevier Science, �2015 _z9780128001400 _w(OCoLC)935189889 _w(DLC) 2015949020
830		0	_aTranslational epigenetics series.
856	4	0	_3ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780128001400
999			_c247191 _d247191