000			04163cam a2200481Ii 4500
001			ocn927437815
003			OCoLC
005			20190328114813.0
006			m o d
007			cr un|||||||||
008			151104t20162016enka ob 000 0 eng d
040			_aOPELS _beng _erda _epn _cOPELS _dMMU _dUIU _dOCLCQ _dDEBBG _dVT2 _dVLB _dD6H _dIAV _dLEATE _dOCLCO _dMERER _dZCU _dOCLCQ _dU3W _dCEF _dCHVBK _dRRP _dOCLCQ _dAU@ _dOCLCO _dOCLCQ _dWYU _dNLGGC _dN9V _dOCLCQ
019			_a927293623 _a1066457182
020			_z9780123948038 _q(print)
020			_z0123948037 _q(print)
035			_a(OCoLC)927437815 _z(OCoLC)927293623 _z(OCoLC)1066457182
050		4	_aQP517.C45
060		4	_aQU 375
082	0	4	_a571.7/4 _223
100	1		_aKramer, Ijsbrand M., _eauthor.
245	1	0	_aSignal transduction / _h[electronic resource] _cIjsbrand M. Kramer.
250			_a3rd ed.
264		1	_aLondon : _bElsevier/Academic Press, _c2016.
264		4	_c�2016
300			_a1 online resource : _billustrations (chiefly color)
336			_atext _btxt _2rdacontent
336			_astill image _bsti _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
504			_aIncludes bibliographical references.
505	0		_aPrologue : signal transduction from an historical perspective -- An introduction to signal transduction -- Regulation of muscle contraction by adrenoceptors -- Cholinergic signaling and muscle contraction -- Sensory signal processing; visual transduction and olfaction -- Intracellular calcium -- Bringing the signal into the nucleus : regulation of gene expression -- Nuclear receptors -- Protein kinase c in oncogenic transformation and cell polarity -- Regulation of cell proliferation by receptor tyrosine protein kinases -- Signal transduction to and from adhesion molecules -- WNT signaling and the regulation of cell adhesion and differentiation -- Activation of the innate immune system : the toll-like receptor-4 and signaling through ubiquitinylation -- Chemokines and traffic of white blood cells -- Activating the adaptive immune system : role of non-receptor tyrosine kinases -- Signaling through the insulin receptor : phosphoinositide 3-kinases and AKT -- TGF[beta] and signaling through receptor serine/threonine protein kinases -- Protein phosphatases -- Cell fate determination by notch.
588	0		_aOnline resource; title from PDF title page (ScienceDirect, viewed November 4, 2015).
520			_a"A reference on cellular signaling processes, the third edition of Signal Transduction continues in the tradition of previous editions, in providing a historical overview of how the concept of stimulus-response coupling arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, growth factors and adhesion molecules. In a new chapter, an introduction to signal transduction, the book provides a concise overview of receptor mechanisms, from receptor -ligand interactions to post-translational modifications operational in the process of bringing about cellular changes. The phosphorylation process, from bacteria to men, is discussed in detail. Signal transduction third edition further elaborates on diverse signaling cascades within particular contexts such as muscle contraction, innate and adaptive immunity, glucose metabolism, regulation of appetite, oncogenic transformation and cell fate decision during development or in stem cell niches. The subjects have been enriched with descriptions of the relevant anatomical, histological, physiological or pathological condition."--Page 4 of cover.
650		0	_aCellular signal transduction.
650		6	_aTransduction du signal cellulaire.
650		7	_aSCIENCE _xLife Sciences _xCell Biology. _2bisacsh
650		7	_aCellular signal transduction. _2fast _0(OCoLC)fst00850288
650	1	7	_aSignalen. _2gtt
650	1	2	_aSignal Transduction.
655		4	_aElectronic books.
776	0	8	_iErscheint auch als: _nDruck-Ausgabe _aKramer, Ijsbrand M. _tSignal transduction _w(DE-604)BV043329994
856	4	0	_3ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780123948038
999			_c247209 _d247209