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019 _a932332263
_a934189605
_a1066620153
_a1088984620
020 _a9780128005521
_q(electronic bk.)
020 _a0128005521
_q(electronic bk.)
020 _z0128005483
_q(Trade Cloth)
020 _z9780128005484
_q(Trade Cloth)
020 _a0128005483
020 _a9780128005484
024 3 _a9780128005484
035 _a(OCoLC)930023644
_z(OCoLC)932332263
_z(OCoLC)934189605
_z(OCoLC)1066620153
_z(OCoLC)1088984620
050 4 _aR857.T55
_bT73 2016eb
060 4 _aWO 515
060 4 _aQS 525
072 7 _aHEA
_x012000
_2bisacsh
072 7 _aHEA
_x020000
_2bisacsh
072 7 _aMED
_x004000
_2bisacsh
072 7 _aMED
_x101000
_2bisacsh
072 7 _aMED
_x109000
_2bisacsh
072 7 _aMED
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082 0 4 _a610.28
_223
245 0 0 _aTranslating regenerative medicine to the clinic /
_h[electronic resource]
_cedited by: Jeffrey Laurence ; guest editors: Pedro Baptista Anthony Atala, Mary van Beusekom.
264 1 _aLondon :
_bAcademic Press,
_c2016.
264 4 _c�2016
300 _a1 online resource (xiv, 339 pages).
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aAdvances in translational medicine
500 _aAcademic Press is an imprint of Elsevier.
588 0 _aOnline resource; title from title details screen (ScienceDirect, viewed December 2, 2015).
505 0 _aFront Cover; Translating Regenerative Medicine to the Clinic; Copyright; Contents; Contributors; I -- Introduction; 1 -- Regenerative Medicine: The Hurdles and Hopes; Key Concepts; 1. INTRODUCTION; 2. ON THE ORIGINS OF REGENERATIVE MEDICINE; 3. FROM CELLS AND SCAFFOLDS TO TISSUES AND ORGANS; 4. BIOMATERIALS, TISSUE AND ORGAN BIOENGINEERING; 5. GENE THERAPY; 6. STEM CELL THERAPIES; 7. FUTURE DIRECTIONS; REFERENCES; II -- Biomaterials and Tissue/Organ Bioengineering; 2 -- Extracellular Matrix as an Inductive Scaffold for Functional Tissue Reconstruction; Key Concepts; 1. INTRODUCTION.
505 8 _a2. ECM AS A SCAFFOLD FOR REGENERATIVE MEDICINE2.1 The ECM as a Mechanical Substrate; 2.2 ECM Composition; 2.3 Dynamic Reciprocity; 2.4 Bioactive Degradation Products; 2.5 ECM as an Instructive Niche for Stem Cells; 3. DECELLULARIZATION AND FABRICATION METHODS; 4. TRANSLATIONAL APPLICATIONS OF ECM IN REGENERATIVE MEDICINE; 4.1 Esophageal Disease; 4.2 Volumetric Muscle Loss; 4.3 Temporomandibular Joint Meniscectomy; 5. MECHANISMS OF CONSTRUCTIVE REMODELING; 5.1 Mechanical Forces; 5.2 Modulation of the Host Response; 5.3 ECM Scaffold Degradation.
505 8 _a5.4 Undesirable Responses to ECM Scaffold Materials6. CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 3 -- Whole-Organ Bioengineering-Current Tales of Modern Alchemy; Key Concepts; 1. INTRODUCTION; 2. CURRENT STATUS OF ORGAN TRANSPLANTATION; 3. CURRENT STATUS ON ORGAN BIOENGINEERING; 3.1 Liver; 3.2 Intestine; 3.3 Kidney; 3.4 Heart; 3.5 Pancreas; 3.6 Lungs; 4. CURRENT APPLICATIONS FOR BIOENGINEERED ORGANS; 5. CURRENT LIMITATIONS; 5.1 Cell Sources and Expansion; 5.2 Assembly of Patent Vascular Networks; 5.3 Enabling Bioreactor Technologies; 5.4 Regulatory Challenges, Scaling Up, and Other Issues.
505 8 _a6. CONCLUSIONSREFERENCES; 4 -- Regenerative Implants for Cardiovascular Tissue Engineering; 1. INTRODUCTION; 1.1 The Path to a Regenerative Approach; 1.2 Brief Historical Overview of Vascular, Heart Valve, and Heart Implants; 1.2.1 Vascular Implants; 1.2.2 Heart Valve; 1.2.3 Whole Heart; 2. TYPES OF REGENERATIVE IMPLANTS-THE CONTINUITY BRIDGE; 2.1 Synthetic; 2.1.1 Degradable Synthetic Polymers; 2.1.2 Fabrication Methods; 2.2 Biologic; 2.2.1 ECM Gels; 2.2.2 Decellularized Scaffolds; 2.2.3 Hybrid; 3. FUNCTION OF IMPLANTS; 3.1 Implants as a Cell Delivery Vehicle Grown In Vitro.
505 8 _a3.1.1 Endothelial Progenitor Cells and MSCs3.1.2 Embryonic and Inducible Stem Cells; 3.1.3 BM Cells; 3.1.4 Cell Seeding Techniques; 3.2 Implants as an In Situ "Cell-Free" Tissue Forming Device; 3.3 Implants as a Drug Delivery Vehicle; 4. CLINICAL APPLICATIONS IN CARDIOVASCULAR REPAIR; 4.1 Vascular; 4.1.1 Vascular Patch; 4.1.2 Vascular Grafts; 4.2 Heart Valve; 4.3 Heart; 5. CONCLUSION; ACKNOWLEDGMENT; REFERENCES; 5 -- Tissue Engineering and Regenerative Medicine: Gastrointestinal Application; Key Concepts; 1. THE GASTROINTESTINAL TRACT: OVERVIEW; 2. NEURODEGENERATIVE DISEASES OF THE GI TRACT.
520 8 _aThis review of current methodological tools and experimental approaches used by leading translational researchers, discusses the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle regeneration and regeneration of the bone and skin. Pedagogically, it concentrates on the latest knowledge, laboratory techniques and experimental approaches used by research leaders in the field. It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by emphasising recent innovations, critical barriers to progress, the new tools that are being used to overcome them and specific areas of research that require additional study to advance the field as a whole.
504 _aIncludes bibliographical references and index.
650 0 _aRegenerative medicine.
650 0 _aClinical medicine.
650 0 _aBiomedical materials.
650 0 _aGene therapy.
650 0 _aTissue engineering.
650 7 _aHEALTH & FITNESS
_xHolism.
_2bisacsh
650 7 _aHEALTH & FITNESS
_xReference.
_2bisacsh
650 7 _aMEDICAL
_xAlternative Medicine.
_2bisacsh
650 7 _aMEDICAL
_xAtlases.
_2bisacsh
650 7 _aMEDICAL
_xEssays.
_2bisacsh
650 7 _aMEDICAL
_xFamily & General Practice.
_2bisacsh
650 7 _aMEDICAL
_xHolistic Medicine.
_2bisacsh
650 7 _aMEDICAL
_xOsteopathy.
_2bisacsh
650 7 _aBiomedical materials.
_2fast
_0(OCoLC)fst00832586
650 7 _aClinical medicine.
_2fast
_0(OCoLC)fst00864361
650 7 _aGene therapy.
_2fast
_0(OCoLC)fst00939638
650 7 _aRegenerative medicine.
_2fast
_0(OCoLC)fst01745494
650 7 _aTissue engineering.
_2fast
_0(OCoLC)fst01151484
650 1 2 _aTissue Engineering.
_0(DNLM)D023822
650 1 2 _aCell- and Tissue-Based Therapy.
_0(DNLM)D064987
650 2 2 _aGenetic Therapy.
_0(DNLM)D015316
650 2 2 _aClinical Laboratory Techniques.
_0(DNLM)D019411
650 2 2 _aTranslational Medical Research.
_0(DNLM)D057170
650 2 _aRegenerative Medicine
_xmethods.
_0(DNLM)D044968Q000379
655 7 _aElectronic books.
_2lcgft
655 4 _aElectronic books.
700 1 _aLaurence, Jeffrey,
_eeditor.
700 1 _aBaptista, Pedro
_q(Pedro M.),
_eeditor.
700 1 _aAtala, Anthony,
_d1958-
_eeditor.
700 1 _aVan Beusekom, Mary,
_eeditor.
776 0 8 _iPrint version:
_aLaurence, Jeffrey.
_tTranslating Regenerative Medicine to the Clinic.
_dSaint Louis : Elsevier Science, �2015
_z9780128005484
_w(OCoLC)948776104
830 0 _aAdvances in translational research.
856 4 0 _3ScienceDirect
_uhttp://www.sciencedirect.com/science/book/9780128005484
999 _c247228
_d247228