000			04741cam a2200529Ii 4500
001			ocn945376540
003			OCoLC
005			20190328114814.0
006			m o d
007			cr bn|---a|cuu
008			160322s2016 enka ob 000 0 eng d
040			_aOPELS _beng _erda _epn _cOPELS _dUIU _dYDX _dU3W _dSTF _dD6H _dAU@ _dOCLCQ _dOCLCO
019			_a957680214
020			_a9780128005101
020			_a0128005106
020			_z9780128002766
020			_z012800276X
035			_a(OCoLC)945376540 _z(OCoLC)957680214
050		4	_aRB155.8
060		4	_aQZ 50
082	0	4	_a615.8/95 _223
245	0	0	_aAdenoviral vectors for gene therapy / _h[electronic resource] _cedited by David T. Curiel.
250			_a2nd ed.
264		1	_aLondonm UK : _bAcademic Press is an imprint of Elsevier, _c2016.
300			_a1 online resource : _billustrations
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
504			_aIncludes bibliographical references.
588	0		_aOnline resource; title from PDF title page (ScienceDirect, viewed March 22, 2016).
505	0		_aFront Cover; Adenoviral Vectors for Gene Therapy; Adenoviral Vectors for Gene Therapy; Copyright; Contents; List of Contributors; 1 -- Adenovirus Structure; 1. Historical Perspective on Adenovirus Structure; 2. Hexon Structure and Capsid Packing; 3. Penton Base Structure and Integrin-Binding RGD Loop; 4. Fiber Structure and Receptor Interactions; 5. Atomic Resolution Cryo-Electron Microscopy and X-ray Crystallographic Adenovirus Structures; 6. Hexons in the Atomic Resolution Adenovirus Structures; 7. Conformational Differences of the Penton Base in the Atomic Resolution Adenovirus Structures.
505	8		_a8. Alternate Assignments for the Four-Helix Coiled Coil9. Protein IIIa Structure; 10. Protein IX Structure; 11. Core Protein V Structure; 12. Protein VI Structure; 13. Protein VIII Structure; 14. Adenovirus Protease; 15. Concluding Remarks; References; 2 -- Biology of Adenovirus Cell Entry: Receptors, Pathways, Mechanisms; 1. Introduction; 2. Entry Pathways: Impact of Capsid Proteins; 3. Attachment Factors and Signaling Receptors; 3.1 Accessing the CAR; 3.2 Using CD46 in High- and Low-Affinity Modes; 3.3 Desmoglein-2; 3.4 Sialic Acid; 3.5 Heparan Sulfate.
505	8		_a3.6 Scavenger Receptors and Other Attachment Factors3.7 Internalization Co-receptors: Integrins; 3.8 Extracellular Factors Influencing Viral Tropism; 3.8.1 Coagulation Factors; 3.8.2 Immunoglobulins and Complement; 3.8.3 Lactoferrin; 3.8.4 Dipalmitoylphosphatidylcholine; 4. Endocytosis; 4.1 Clathrin-Mediated Endocytosis; 4.2 Macropinocytosis; 4.3 Phagocytosis; 4.4 Caveolar Endocytosis; 5. Endosomal Escape; 5.1 Protein VI for Membrane Lysis; 5.2 A New Concept: Hijacking Membrane Repair for Endosome Lysis; 6. Targeting the Nucleus; 6.1 Transport through the Cytoplasm.
505	8		_a6.2 Deoxyribonucleic Acid Uncoating and Nuclear Import7. Conclusions and Perspectives; Acknowledgments; References; 3 -- Adenovirus Replication; 1. Introduction; 2. Classification; 3. Adenovirus Genome Organization; 4. Virus Infection; 5. Early Gene Expression; 5.1 Early Region 1A; 5.2 Early Region 1B; 5.3 Early Region 2; 5.4 Early Region 3; 5.5 Early Region 4; 6. Viral DNA Replication; 7. Virus-Associated RNA Genes; 8. Late Gene Expression; 9. Viral DNA Packaging; 10. Conclusion; References; 4 -- Adenoviral Vector Construction I: Mammalian Systems; 1. Introduction; 1.1 Adenovirus Biology.
505	8		_a1.2 Adenovirus Vectors2. Cell Lines for Propagating Adenovirus Vectors; 2.1 Propagation of Adenovirus Vectors Encoding Toxic Transgenes for Cancer Gene Therapy; 3. Construction of First-Generation Adenoviral Vectors; 3.1 Early Methods; 3.2 The Two-Plasmid Rescue System; 3.2.1 Development of the Two-Plasmid Rescue System; 3.2.2 Fine-Tuning of the Two-Plasmid Rescue System; 4. Steps Involved in Adenovirus Vector Construction; 4.1 Preparation of Adenovirus Genomic and Shuttle Plasmid DNA for Cotransfection; 4.2 Cotransfection of HEK-293 Cells with Genomic and Shuttle Plasmid.
650		0	_aGene therapy.
650		0	_aAdenoviruses.
650		7	_aHEALTH & FITNESS _xDiseases _xGenetic. _2bisacsh
650		7	_aMEDICAL _xGenetics. _2bisacsh
650		7	_aAdenoviruses. _2fast _0(OCoLC)fst00796586
650		7	_aGene therapy. _2fast _0(OCoLC)fst00939638
650		2	_aGenetic Therapy _xmethods.
655		4	_aElectronic books.
700	1		_aCuriel, David, _eeditor.
776	0	8	_iPrint version: _tAdenoviral vectors for gene therapy. _d[S.l.] : Elsevier Academic Press, 2016 _z012800276X _w(OCoLC)932262256
856	4	0	_3ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780128002766
999			_c247306 _d247306