000			02779cam a22004095i 4500
001			21819026
003			BD-DhUL
005			20211012143255.0
006			m |o d |
007			cr |||||||||||
008			180627s2018 sz |||| |b |||1 0|eng
010			_a 2019764757
020			_a9783319906942 (hbk)
024	7		_a10.1007/978-3-319-90695-9 _2doi
035			_a(DE-He213)978-3-319-90695-9
040			_aDLC _beng _epn _erda _cDLC _dBD-DhUL
072		7	_aPSAK _2bicssc
072		7	_aPSAK _2thema
072		7	_aSCI017000 _2bisacsh
082	0	4	_a571.6 _bSTE
245	1	0	_aStem cell genetics for biomedical research : _bpast, present, and future / _cedited by Raul Delgado-Morales.
264			_aCham : _bSpringer, _c2018.
300			_axi, 426 p. : _bill. ( some col.) ; _c24 cm.
365			_aEuro _b139.99
504			_aIncludes bibliographical references and index.
520			_aThis book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer's disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment. In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.
588			_aDescription based on publisher-supplied MARC data.
650		0	_aCell biology.
650		0	_aHuman genetics.
650		0	_aMolecular biology.
700	1		_aDelgado-Morales, Raul. _eed.
776	0	8	_iPrint version: _tStem cell genetics for biomedical research : past, present, and future _z9783319906942 _w(DLC) 2018945917
776	0	8	_iPrinted edition: _z9783030080761
776	0	8	_iPrinted edition: _z9783319906942
776	0	8	_iPrinted edition: _z9783319906966
942			_2ddc _cBK
999			_c252950 _d252950