000			03806cam a22003735i 4500
001			21675973
003			BD-DhUL
005			20211013154347.0
006			m |o d |
007			cr |||||||||||
008			181130s2018 sz |||| |b |||1 0|eng
010			_a 2019743895
020			_a9783319995922 (hbk)
035			_a(DE-He213)978-3-319-99593-9
040			_aDLC _beng _epn _erda _cDLC _dBD-DhUL
072		7	_aMED072000 _2bisacsh
072		7	_aTDC _2thema
072		7	_aTDCW _2bicssc
082			_a615.19 _bADM
245	1	0	_aADME processes in pharmaceutical sciences : _bdosage, design, and pharmacotherapy success / _cedited by Alan Talevi, Pablo A. M. Quiroga.
260			_aCham : _bSpringer, _c2018.
300			_ax, 369 p. : _bill. (chiefly) ; _c24 cm.
365			_aEuro _b109.99
504			_aIncludes bibliographical references and index.
520			_aAbsorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. As an introduction oriented to pharmacy students, it is also written for scientist from different fields outside of pharmaceutics. (e.g. material scientist, material engineers, medicinal chemists) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and some biological background. Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies add valuable teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), in vitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, and in silico and in vitro prediction of ADME properties. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and was written with leading experts on the correspondent topic, including scientists and academics from USA and UK (Duquesne University School of Pharmacy, Indiana University School of Medicine, University of Utah College of Pharmacy, University of Maryland, University of Bath). Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations (e.g. importance of active absorption of levodopa, implications in levodopa administration, drug drug interactions and food drug interactions emerging from the active uptake; intoxication with paracetamol as a result of glutathione depletion, CYP induction and its relationship with acute liver failure caused by paracetamol, etc). ADME Processes and Pharmaceutical Sciences is written as a core textbook for ADME processes, pharmacy, pharmacokinetics, drug delivery, biopharmaceutics, drug disposition, drug design and medicinal chemistry courses.
588			_aDescription based on publisher-supplied MARC data.
650		0	_aPharmaceutical technology.
700	1		_aTalevi, Alan. _eed.
700	1		_aQuiroga, Pablo A. M. _eed.
776	0	8	_iPrint version: _tADME processes in pharmaceutical sciences : dosage, design, and pharmacotherapy success _z9783319995922 _w(DLC) 2018965237
776	0	8	_iPrinted edition: _z9783319995922
776	0	8	_iPrinted edition: _z9783319995946
942			_2ddc _cBK
999			_c253648 _d253648