000			03587cam a22003977a 4500
001			17278804
003			BD-DhUL
005			20150121172301.0
008			120430s2012 gw a b 001 0 eng d
010			_a 2012392592
016	7		_a015904442 _2Uk
020			_a9783527331291
035			_a(OCoLC)ocn753624304
040			_aBTCTA _beng _cBTCTA _dBD-DhUL _dBD-DhUL
042			_alccopycat
050	0	0	_aRS189 _b.M36 2012
072		7	_aR _2lcco
082	0	4	_a615.1901 _bMAH
100	1		_aMascher, Hermann.
245	1	0	_aHPLC methods for clinical pharmaceutical analysis : _ba user's guide / _cHermann Mascher.
250			_a1st ed.
260			_aWeinheim : _bWiley-VCH, _cc2012.
300			_aix, 247 p. : _bill. ; _c25 cm.
365			_aUS$ _b81.95
504			_aIncludes bibliographical references and index.
505	0		_a1.Introduction -- 1.1.First Question: Determination of Ibuprofen in Plasma -- 1.2.Second Question: Determination of Tryptophan in Urine -- 1.3.Third Question: Determination of Paclitaxel in Tissue -- 2.Planning of Analyses -- 2.1.Introduction -- 2.2.Limit of Detection (LOD) and Determination (LLOQ) -- 2.3.Detectors -- 2.4.Structure of the Analyte -- 2.5.Solubility of an Analyte -- 2.6.Selection of the Detector -- 3.Sample Preparation -- 3.1.Dilution -- 3.2.Protein Precipitation, Overview -- 3.3.Extraction -- 4.HPLC Separation -- 4.1.HPLC Pumps -- 4.2.Degasser -- 4.3.Injector -- 4.4.HPLC Columns -- 5.Detection -- 5.1.Detection in the Pharmaceutical/Bioanalytical Area -- 5.2.Detection in the "Clinical Area" (Therapy Control/Compliance) -- 6.Chemical Derivatization for Detection Enhancement -- 7.Validation Concepts -- 7.1.Introduction -- 7.2.Realization of the FDA Guideline -- 8.Practical Hints Concerning Stability, Destruction and Degradation Products -- 9.Metabolites -- 10.Internal Standards -- 11.Case Studies with Intensive Discussion for Each Substance -- 11.1.Acetylcarnitine in Plasma -- 11.2.Acetylcysteine in Plasma -- 11.3.Acyclovir in Plasma and Urine -- 11.4.Caffeine in Plasma -- 11.5.Diazepam in Plasma -- 11.6.Diclofenac in Plasma -- 11.7.Dihydralazine in Plasma -- 11.8.Duramycin (Moli1901) in Plasma -- 11.9.Fluticasone Propionate in Plasma -- 11.10.Hydroxytriamterene Sulfate and Triamterene in Plasma and Urine -- 11.11.Ibuprofen in Plasma (also Enantiomeric Separation) -- 11.12.Minocycline in Plasma -- 11.13.Norfloxacine in Plasma and Urine -- 11.14.Paclitaxel in Plasma, Urine and Tissue -- 11.15.Paracetamol (Acetaminophen) in Plasma -- 11.16.Pimelic Acid in Plasma and Urine -- 11.17.8-Prenylnaringenin in Plasma and Different Types of Tissues -- 11.18.Silibinin in Plasma -- 11.19.Valnemulin in Plasma, Different Tissue Types and in Animal Feed -- 11.20.Vitamin B1 (Total Thiamine) in Plasma -- Table 11.1 Recommended books -- Table 11.2 Properties of substances -- Appendix -- Short Description of Determination for about 100 Substances -- Substances listed in the Appendix.
650		0	_aHigh performance liquid chromatography.
650		0	_aDrugs _xAnalysis.
650		0	_aPharmaceutical technology.
856	4	2	_3Contributor biographical information _uhttp://www.loc.gov/catdir/enhancements/fy1210/2012392592-b.html
856	4	2	_3Publisher description _uhttp://www.loc.gov/catdir/enhancements/fy1210/2012392592-d.html
856	4	1	_3Table of contents only _uhttp://www.loc.gov/catdir/enhancements/fy1210/2012392592-t.html
906			_a7 _bcbc _ccopycat _d2 _encip _f20 _gy-gencatlg
942			_2ddc _cBK
955			_bxh15 2012-04-30 z-processor to xh00 _ath79 2012-05-01 to USPL/STM _ixh14 2012-05-29 to BCCD
999			_c34801 _d34801