Autophagy : Volume 4 : Cancer, other pathologies, inflammation, immunity, infection, and aging / [electronic resource]
edited by M.A. Hayat ; contributors Hagai Abeliovich [and thirty seven others].
- 1 online resource (315 pages) : illustrations
Includes bibliographical references and index.
Introduction to Autophagy: cancer, other pathologies, inflammation, immunity, infection, and aging, volume 4 / General applications. Molecular process and physiological significance of mitophagy / Principles of mitophagy and beyond / Quality control in mitochondria / Mitophagy: an overview / Molecular mechanisms. Mitophagy induction and curcumin-mediated sonodynamic chemotherapy / Role of nix in the maturation of erythroid cells through mitochondrial autotophagy / Role of the antioxidant melatonin in regulating autophagy and mitophagy / Ubiquitin ligase-assisted selective autophagy of mitochondria: determining its biological significance using drosophilia models / Atg32 confers selective mitochondrial sequestration as a cargo for autophagy / Yusuke Kurihara, Tomotake Kanki -- PARK2 induces autophagy removal of impaired mitochodria via ubiquitination / Ubiquination of mitofusins in PINK1/Parkin-mediated mitophagy / Mitochondrial alterations in mitophagy in response to 6-hydroxydopamine / Role in disease. Role of mitochondrial fission and mitophagy in Parkinson's Disease / Mitophagy controlled by the PINK1-Parkin pathway is associated with Parkinson's Disease pathogenesis / Loss of mitochondria during skeletal muscle atrophy / Role of impaired mitochondrial autophagy in cardiac aging / M.A. Hayat -- Ke Wang, Daniel J. Klionsky -- Avia M. Tolkovsky, Kim Tieu -- Kobi J. Simpson-Lavy, Hagai Abeliovich -- Dalibor Mijaljica, Mark Prescott, Rodney J. Devenish -- Chuanshan Xu, Wingnang Leung -- Huanhuan Sun [and others] -- Jose A. Boga, Ana Coto-Montes, Russel J. Reiter -- Tsuyoshi Inoshita, Yuzuru Imai -- Kah-Leong Lim [and others] -- Matthew E. Gegg -- Joaqu�in Jord�an, Mar�ia E. Solesio, Mar�ia F. Galindo -- Mar�ia F. Galindo, Mar�ia E. Solesio, Joaqu�in Jord�an -- Yuzuru Imai, Nobutaka Hattori -- Sudarsanreddy Lokireddy -- Emanuele Marzetti [and others]. Chapter 1. 1. Chapter 2. Chapter 3. Chapter 4. Chapter 5. 2. Chapter 6. Chapter 7. Chapter 8. Chapter 9. Chapter 10. Chapter 11. Chapter 12. Chapter 13. 3. Chapter 14. Chapter 15. Chapter 16. Chapter 17.
Annotation Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volume 4 - Mitophagypresents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson's Disease, cardiac aging, and skeletal muscle atrophy. The most current understanding of the proteins and pathways involved in mitophagy are covered, with specific attention to Nix and Bnip3, PINK1/Parkin, Atg32, and FUNDC1. The role of mitophagy in cancer, neurodegeneration, aging, infection, and inflammation is also discussed providing essential insights into the pathogenesis of a variety of mitochondria dysfunction-related diseases. This book is an asset to newcomers as a concise overview of the current knowledge on mitophagy, while serving as an excellent update reference for more experienced scientists working on other aspects of autophagy. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. . Brings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field . Discusses in detail myriad aspects of yeast mitophagy, including proteins involved, generation of reactive oxygen species (ROS), and various mechanisms of mitochondrial quality control. Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level . Organized for readers into easy-to-access sections: general applications; molecular mechanisms; and role in disease.
9780124055339 0124055338 0124055281 9780124055285
9780124055285
Autophagic vacuoles.
Autophagy.
Mitochondrial Degradation.
SCIENCE--Life Sciences--Anatomy & Physiology.
Autophagic vacuoles.
Electronic books.
Electronic book.
QH603.L9 / .A986 2014eb
571.655
Includes bibliographical references and index.
Introduction to Autophagy: cancer, other pathologies, inflammation, immunity, infection, and aging, volume 4 / General applications. Molecular process and physiological significance of mitophagy / Principles of mitophagy and beyond / Quality control in mitochondria / Mitophagy: an overview / Molecular mechanisms. Mitophagy induction and curcumin-mediated sonodynamic chemotherapy / Role of nix in the maturation of erythroid cells through mitochondrial autotophagy / Role of the antioxidant melatonin in regulating autophagy and mitophagy / Ubiquitin ligase-assisted selective autophagy of mitochondria: determining its biological significance using drosophilia models / Atg32 confers selective mitochondrial sequestration as a cargo for autophagy / Yusuke Kurihara, Tomotake Kanki -- PARK2 induces autophagy removal of impaired mitochodria via ubiquitination / Ubiquination of mitofusins in PINK1/Parkin-mediated mitophagy / Mitochondrial alterations in mitophagy in response to 6-hydroxydopamine / Role in disease. Role of mitochondrial fission and mitophagy in Parkinson's Disease / Mitophagy controlled by the PINK1-Parkin pathway is associated with Parkinson's Disease pathogenesis / Loss of mitochondria during skeletal muscle atrophy / Role of impaired mitochondrial autophagy in cardiac aging / M.A. Hayat -- Ke Wang, Daniel J. Klionsky -- Avia M. Tolkovsky, Kim Tieu -- Kobi J. Simpson-Lavy, Hagai Abeliovich -- Dalibor Mijaljica, Mark Prescott, Rodney J. Devenish -- Chuanshan Xu, Wingnang Leung -- Huanhuan Sun [and others] -- Jose A. Boga, Ana Coto-Montes, Russel J. Reiter -- Tsuyoshi Inoshita, Yuzuru Imai -- Kah-Leong Lim [and others] -- Matthew E. Gegg -- Joaqu�in Jord�an, Mar�ia E. Solesio, Mar�ia F. Galindo -- Mar�ia F. Galindo, Mar�ia E. Solesio, Joaqu�in Jord�an -- Yuzuru Imai, Nobutaka Hattori -- Sudarsanreddy Lokireddy -- Emanuele Marzetti [and others]. Chapter 1. 1. Chapter 2. Chapter 3. Chapter 4. Chapter 5. 2. Chapter 6. Chapter 7. Chapter 8. Chapter 9. Chapter 10. Chapter 11. Chapter 12. Chapter 13. 3. Chapter 14. Chapter 15. Chapter 16. Chapter 17.
Annotation Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volume 4 - Mitophagypresents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson's Disease, cardiac aging, and skeletal muscle atrophy. The most current understanding of the proteins and pathways involved in mitophagy are covered, with specific attention to Nix and Bnip3, PINK1/Parkin, Atg32, and FUNDC1. The role of mitophagy in cancer, neurodegeneration, aging, infection, and inflammation is also discussed providing essential insights into the pathogenesis of a variety of mitochondria dysfunction-related diseases. This book is an asset to newcomers as a concise overview of the current knowledge on mitophagy, while serving as an excellent update reference for more experienced scientists working on other aspects of autophagy. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. . Brings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field . Discusses in detail myriad aspects of yeast mitophagy, including proteins involved, generation of reactive oxygen species (ROS), and various mechanisms of mitochondrial quality control. Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level . Organized for readers into easy-to-access sections: general applications; molecular mechanisms; and role in disease.
9780124055339 0124055338 0124055281 9780124055285
9780124055285
Autophagic vacuoles.
Autophagy.
Mitochondrial Degradation.
SCIENCE--Life Sciences--Anatomy & Physiology.
Autophagic vacuoles.
Electronic books.
Electronic book.
QH603.L9 / .A986 2014eb
571.655