Includes bibliographical references and index.

Chapter 1. Introduction to Autophagy: cancer, other pathologies, inflammation, immunity, infection, and aging, volume 4 / M.A. Hayat -- 1. General applications. Chapter 2. Molecular process and physiological significance of mitophagy / Ke Wang, Daniel J. Klionsky -- Chapter 3. Principles of mitophagy and beyond / Avia M. Tolkovsky, Kim Tieu -- Chapter 4. Quality control in mitochondria / Kobi J. Simpson-Lavy, Hagai Abeliovich -- Chapter 5. Mitophagy: an overview / Dalibor Mijaljica, Mark Prescott, Rodney J. Devenish -- 2. Molecular mechanisms. Chapter 6. Mitophagy induction and curcumin-mediated sonodynamic chemotherapy / Chuanshan Xu, Wingnang Leung -- Chapter 7. Role of nix in the maturation of erythroid cells through mitochondrial autotophagy / Huanhuan Sun [and others] -- Chapter 8. Role of the antioxidant melatonin in regulating autophagy and mitophagy / Jose A. Boga, Ana Coto-Montes, Russel J. Reiter -- Chapter 9. Ubiquitin ligase-assisted selective autophagy of mitochondria: determining its biological significance using drosophilia models / Tsuyoshi Inoshita, Yuzuru Imai -- Chapter 10. Atg32 confers selective mitochondrial sequestration as a cargo for autophagy / Yusuke Kurihara, Tomotake Kanki -- Chapter 11. PARK2 induces autophagy removal of impaired mitochodria via ubiquitination / Kah-Leong Lim [and others] -- Chapter 12. Ubiquination of mitofusins in PINK1/Parkin-mediated mitophagy / Matthew E. Gegg -- Chapter 13. Mitochondrial alterations in mitophagy in response to 6-hydroxydopamine / Joaqu�in Jord�an, Mar�ia E. Solesio, Mar�ia F. Galindo -- 3. Role in disease. Chapter 14. Role of mitochondrial fission and mitophagy in Parkinson's Disease / Mar�ia F. Galindo, Mar�ia E. Solesio, Joaqu�in Jord�an -- Chapter 15. Mitophagy controlled by the PINK1-Parkin pathway is associated with Parkinson's Disease pathogenesis / Yuzuru Imai, Nobutaka Hattori -- Chapter 16. Loss of mitochondria during skeletal muscle atrophy / Sudarsanreddy Lokireddy -- Chapter 17. Role of impaired mitochondrial autophagy in cardiac aging / Emanuele Marzetti [and others].

Online resource; title from PDF title page (ebrary, viewed August 9, 2014).

Annotation Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volume 4 - Mitophagypresents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson's Disease, cardiac aging, and skeletal muscle atrophy. The most current understanding of the proteins and pathways involved in mitophagy are covered, with specific attention to Nix and Bnip3, PINK1/Parkin, Atg32, and FUNDC1. The role of mitophagy in cancer, neurodegeneration, aging, infection, and inflammation is also discussed providing essential insights into the pathogenesis of a variety of mitochondria dysfunction-related diseases. This book is an asset to newcomers as a concise overview of the current knowledge on mitophagy, while serving as an excellent update reference for more experienced scientists working on other aspects of autophagy. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. . Brings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field . Discusses in detail myriad aspects of yeast mitophagy, including proteins involved, generation of reactive oxygen species (ROS), and various mechanisms of mitochondrial quality control. Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level . Organized for readers into easy-to-access sections: general applications; molecular mechanisms; and role in disease.