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Mass spectrometry : techniques for structural characterization of glycans / [electronic resource]

by Madson, Michael A.
Material type: materialTypeLabelBookPublisher: Amsterdam, Netherlands : Elsevier, 2016Description: 1 online resource.ISBN: 0128041358; 9780128041352; 0128041293; 9780128041291.Subject(s): Glycoproteins -- Spectra | Mass spectrometry | SCIENCE -- Life Sciences -- Biochemistry | Mass spectrometry | Glycoproteins -- analysis | Electronic booksOnline resources: ScienceDirect
Contents:
Title page; Table of Contents; Copyright; Dedication; Mass Spectral Analysis of Carbohydrates; Abstract; 1 Isolation Methods for MS Analysis; 2 Component Monosaccharide Analysis by Acid Catalyzed Hydrolysis of Glycan and Qualitative Chromatographic Identification by HPLC; 3 Identification of Glycoses Versus Glycitols by HPAEC-PAD Difference Chromatograms; 4 The Methods for Preparing an Oligosaccharide Reducing Glycan from a Glycoprotein, Linked Through O-Glycosidic Linkage; Conclusions; References.
Summary: Mass Spectrometry: Techniques for the Structural Characterization of Glycans presents new methods for conducting detailed carbohydrate qualitative analysis-arming analytical chemists, pharmaceutical scientists, and food scientists with a quick reference that will allow them to determine the structures of carbohydrates molecules. As there is a need in the scientific community for content specific to structural determination and analysis of new glycoprotein drug, and because structure-activity analysis requires a structural determination of the N- and O-linked oligosaccharides linked to glycol-proteins, this book provides the relevant research that are necessary for advances and new outcomes in this area of study.
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Mass Spectrometry: Techniques for the Structural Characterization of Glycans presents new methods for conducting detailed carbohydrate qualitative analysis-arming analytical chemists, pharmaceutical scientists, and food scientists with a quick reference that will allow them to determine the structures of carbohydrates molecules. As there is a need in the scientific community for content specific to structural determination and analysis of new glycoprotein drug, and because structure-activity analysis requires a structural determination of the N- and O-linked oligosaccharides linked to glycol-proteins, this book provides the relevant research that are necessary for advances and new outcomes in this area of study.

Includes bibliographical references.

Title page; Table of Contents; Copyright; Dedication; Mass Spectral Analysis of Carbohydrates; Abstract; 1 Isolation Methods for MS Analysis; 2 Component Monosaccharide Analysis by Acid Catalyzed Hydrolysis of Glycan and Qualitative Chromatographic Identification by HPLC; 3 Identification of Glycoses Versus Glycitols by HPAEC-PAD Difference Chromatograms; 4 The Methods for Preparing an Oligosaccharide Reducing Glycan from a Glycoprotein, Linked Through O-Glycosidic Linkage; Conclusions; References.

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